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| 1 | Novel role of phosphodiesterase inhibitors in the management of end-stage heart failure显示文摘In advanced heart failure(HF), chronic inotropic therapy with intravenous milrinone, a phosphodiesterase Ⅲ inhibitor, is used as a bridge to advanced management that includes transplantation, ventricular assist device implantation, or palliation. This is especially true when repeated attempts to wean off inotropic support result in symptomatic hypotension, worsened symptoms, and/or progressive organ dysfunction. Unfortunately, patients in this clinical predicament are considered hemodynamically labile and may escape the benefits of guidelinedirected HF therapy. In this scenario, chronic milrinone infusion may be beneficial as a bridge to introduction of evidence based HF therapy. However, this strategy is not well studied, and in general, chronic inotropic infusion is discouraged due to potential cardiotoxicity that accelerates disease progression and proarrhythmic effects that increase sudden death. Alternatively, chronic inotropic support with milrinone infusion is a unique opportunity in advanced HF. This review discusses evidence that long-term intravenous milrinone support may allow introduction of beta blocker(BB) therapy. When used together, milrinone does not attenuate the clinical benefits of BB therapy while BB mitigates cardiotoxic effects of milrinone. In addition, BB therapy decreases the risk of adverse arrhythmias associated with milrinone. We propose that advanced HF patients who are intolerant to BB therapy may benefit from a trial of intravenous milrinone as a bridge to BB initiation. The discussed clinical scenarios demonstrate that concomitant treatment with milrinone infusion and BB therapy does not adversely impact standard HF therapy and may improve left ventricular function and morbidity associated with advanced HF. | Abhishek Jaiswal Vinh Q Nguyen Thierry H Le Jemtel Keith C Ferdinand | 2016 | World Journal of Cardiology2016，8，7： | 4 |
| 2 | Skin fold thickness at abdomen:a simple anthropometric measurement may compliment metabolic syndrome definition in patients with normal waist circumference显示文摘Backgroud and Objectives Previous studies have reported that skin fold thickness (SF) strongly correlated with insulin resistance in the metabolic syndrome (MetS). In this study, we developed a MetS definition by SF at A8 point (SFA8) on Erdheim diagram(MetSSFA8) in essential hypertensive patients. Subjects and Methods Medical records of 268 essential hypertensive patients (126males and 122 females) were analyzed, including 210 non-diabetic patients (NDM group) and 58 patients with diabetes (DM group).The mean age was 61.4 ± 9.9 and 59.0 ± 11.0 years, respectively. The control group consisted of 90 non-diabetic, non-hypertensive patients with a mean age of 58.0 ± 11.3 years. The proposed MetSSFA8 definition included SFA8 specific values ( ≥30 mm in female and ≥27 mm in male) and at least two of the following: raised triglyceride levels ( ≥1.7 mmol/L), or specific treatment for this lipid abnormality; raised blood pressure (SBP≥130 mmHg and/or DBP≥85 mmHg), or treatment of previously diagnosed hypertension;reduced HDL-cholesterol (< 1.03 mmol/L in men, <1.29 mmol/L in women), or specific treatment for this lipid abnormality; raised fasting plasma glucose (≥5.6 mmol/l), or previously diagnosed DM. Metabolic Syndrome by the National Cholesterol Education Program and International Diabetes Federation definitions were determined with abdominal obesity defined by Asia-Pacific criteria for waist circumference (NCEPA and IDFA). Results The percentage of MetS as defined by NCEPA, IDFA and MetSSFA8 in NDM group was lower than that of NCEPA, IDFA and MetSSFA8 in DM group [OR=7.7 (95%CI, 2.9-20.2) and 2.5 (95%CI, 1.4-4.8) and 2.7(95%CI, 1.3-5.6), respectively] and higher than that of the control group [OR=53.3 (95%CI, 16.7-170.6), 5.8 (95%CI, 2.6-13.2) and18.8 (95%CI, 7.3-48.7), respectively]. The percentage of MetS by NCEPA, IDFA and MetSSFA8 in males in NDM group was lower than the percentage of MetS by NCEPA, IDFA and MetSSFA8 in females in NDM group (50.8% and 77.9%, P< 0.001; 15,9% and 67.2%, P< 0.001; 60.3% and 73.8%, P <0.05, respectively). In subjects with normal WC or both normal WC and BMI, the percentage of MetS by SFAS was higher than that the percentage of MetS by NCEPA (36.9% and 50.8%, P< 0.05 and 36.0% and 51.0%, P< 0.05).The sensitivity, specificity, false positive rate, positive predictive value, negative predictive value of MetSSFA8 assessed with NCEPA definitions were 0.87, 0.73, 0.27, 0.79 and 0.82, respectively. There was a close agreement between MetSSFA8 and NCEPA (The coefficient of Kapa was 0.60, P< 0.001). Conclusions The MetSSFA8 definition was developed which may be useful in order to define and manage MetS in patients with normal WC or normal weight. | Toan C Nguyen Thai Q Ngo Son V Nguyen Hieu T Luong Khoa TA Pham Cong D Nguyen | 2006 | Journal of Geriatric Cardiology2006，3，2： | 2 |
| 3 | Single measurement of troponin T for early prediction of infarct size,congestive heart failure,and pulmonary hypertension in an animal model of myocardial infarction显示文摘 | Jiang B H Nguyen Q T Tardif J C | | 0，，3： | 1 |
| 4 | integrated GIS-geostatistics system for environmental modelling Sustainability in the Information Society 显示文摘 | Nguyen C Q Dinh L A | 2001 | 15th International Symposium Informatics for Environmental Protection2001，，2： | 1 |
| 5 | Fuzzy sliding-mode controllers with applications显示文摘 | HA Q P NGUYEN Q H RYE D C | | 0，，： | 1 |
| 6 | Fuzzy sliding-mode controllers with applications显示文摘 | Ha Q P Nguyen Q H Rye D C | 2001 | IEEE Transactions on Industrial Electronics2001，48，1： | 1 |
| 7 | Experimental and modeling studies of the flow properties of maize and waxy maize starch pastes显示文摘 | NGUYEN Q D JENSEN C T B KRISTENSEN P G | 1998 | Chem Eng J1998，70，： | 1 |
| 8 | Con- struction of plasmid- based expression vectors for Bacillus subtilis exhibiting full structural stability显示文摘 | Nguyen H D Nguyen Q A Ferreira R C | 2005 | Plasmid2005，54，3： | 1 |
| 9 | Google Earth as a Tool in2D Hydrodynamic Modeling 显示文摘 | Nguyen Q C Soon K T | 2011 | Computers & Ge-osciences2011，37，1： | 1 |
| 10 | Synthesis, self-assembly, and switching of one-dimensional nanostructures from new crowded aromatics 显示文摘 | Bushey M L Nguyen T Q Nuckolls C | 2003 | J Am Chem Soc2003，125，： | 1 |
| 11 | Lubrication correction for lattice-Boltzmann simulations of particle-fluid suspensions显示文摘 | Nguyen N Q Ladd A J C | 2002 | Physical Review2002，66，： | 1 |
| 12 | Effect fo Initial Cell Seeding Density on 3D-Engineered Silk Fibroin Scaffolds for Artic- ular Cartilage Tissue Engineering 显示文摘 | Talukdar S Nguyen Q T Chen A C | 2011 | Biomaterials2011，32，34： | 1 |
| 13 | Stabilization of an axially moving web via regulation of axial velocity显示文摘 | Nguyen Q C Hong K S | 2011 | Journal of Sound and Vibration2011，330，20： | 1 |
| 14 | A new constitutive rela-tionship for the homogeneous deformation of metals over a wide range of strain显示文摘 | NGUYEN Q C GYZH ZENJI H | 2004 | Acta Materialia2004，52，： | 1 |
| 15 | Transverse vibration control ofaxially moving membranes by regulation of axial velocity 显示文摘 | Nguyen Q C Hong K S | 2012 | IEEE Transactions on Control Systems Technology2012，20，4： | 1 |
| 16 | 显示文摘 | WALKER B KIM C NGUYEN T Q | 2011 | Chemistry of Materials2011，23，： | 1 |
| 17 | A moving Kriging interpolation-based element-free Galerkin method for structural dynamic analysis 显示文摘 | BUI T Q NGUYEN M N ZHANG C | 2011 | Computer Methods in Applied Mechanics and Engineering2011，200，13： | 1 |
| 18 | Fuzzy sliding mode control- ler with applications 显示文摘 | Ha Q P Nguyen Q H Rye D C | 2001 | IEEE Transaction on Industrial Elec- tronics2001，48，1： | 1 |
| 19 | Nonlinearity,Heating,Fatigue and Thixotropy During Cyclic Loading of Asphalt Mixtures显示文摘 | DiBenedetto H Nguyen Q T Sauzéat C | 2011 | Road Materials and Pavement Design2011，12，1： | 1 |
| 20 | Isolation of green tea catechins and their utilization in the food industry显示文摘 | Vuong Q V Stathopoulos C E Nguyen M H | | 0，，： | 1 |
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