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| 1 | Endoscopic anti-reflux therapy for gastroesophageal reflux disease显示文摘Gastroesophageal reflux disease has an increasing incidence and prevalence worldwide.A significant proportion of patients have a suboptimal response to proton pump inhibitors or are unwilling to take lifelong medication due to concerns about long-term adverse effects.Endoscopic anti-reflux therapies offer a minimally invasive option for patients unwilling to undergo surgical treatment or take lifelong medication.The best candidates are those with a good response to proton pump inhibitors and without a significant sliding hiatal hernia.Transoral incisionless fundoplication and nonablative radiofrequency are the techniques with the largest body of evidence and that have been tested in several randomized clinical trials.Band-assisted ligation techniques,anti-reflux mucosectomy,antireflux mucosal ablation,and new plication devices have yielded promising results in recent noncontrolled studies.Nonetheless,the role of endoscopic procedures remains controversial due to limited long-term and comparative data,and no consensus exists in current clinical guidelines.This review provides an updated summary focused on the patient selection,technical details,clinical success,and safety of current and future endoscopic anti-reflux techniques. | Enrique Rodríguez de Santiago Eduardo Albéniz Fermin Estremera-Arevalo Carlos Teruel Sanchez-Vegazo Vicente Lorenzo-Zúñiga | 2021 | World Journal of Gastroenterology2021,27,39: | 9 |
| 2 | Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation显示文摘AIM:To evaluate the long-term results of conventional chemoradiotherapy and laparoscopic mesorectal excision in rectal adenocarcinoma patients without adjuvant therapy.METHODS:Patients with biopsy-proven adenocarcinoma of the rectum staged cT3-T4 by endoscopic ultrasound or magnetic resonance imaging received neoadjuvant continuous infusion of 5-fluorouracil for five weeks and concomitant radiotherapy.Laparoscopic surgery was planned after 5-8 wk.Patients diagnosed with ypT0N0 stage cancer were not treated with adjuvant therapy according to the protocol.Patients with ypT1-2N0 or ypT3-4 or N+were offered 5-fluorouracil-based adjuvant treatment on an individual basis.An external cohort was used as a reference for the findings.RESULTS:One hundred and seventy six patients were treated with induction chemoradiotherapy and 170underwent total mesorectal excision.Cancer staging of ypT0N0 was achieved in 26/170(15.3%)patients.After a median follow-up of 58.3 mo,patients withypT0N0 had five-year disease-free and overall survival rates of 96%(95%CI:77-99)and 100%,respectively.We provide evidence about the natural history of patients with localized rectal cancer achieving a complete response after preoperative chemoradiation.The inherent good prognosis of these patients will have implications for clinical trial design and care of patients.CONCLUSION:Withholding adjuvant chemotherapy after complete response following standard neoadjuvant chemoradiotherapy and laparoscopic mesorectal excision might be safe within an experienced multidisciplinary team. | Xabier García-Albéniz Rosa Gallego Ralf Dieter Hofheinz Gloria Fernández-Esparrach Juan Ramón Ayuso-Colella Josep Antoni Bombí Carles Conill Miriam Cuatrecasas Salvadora Delgado Angels Ginés Rosa Miquel Mario Pagés Estela Pineda Verónica Pereira Aarón Sosa Oscar Reig Iván Victoria Luis Feliz Antonio María de Lacy Antoni Castells Iris Burkholder Andreas Hochhaus Joan Maurel | 2014 | World Journal of Gastroenterology2014,20,42: | 5 |
| 3 | Tardive dyskinesia in 2 patients treatexl with ziprasidone显示文摘 | Ananth J Burgoyne KS Niz D | 2004 | J Psychiatry Nettrosci2004,29,6: | 1 |
| 4 | Face recognition using histograms of oriented gradients显示文摘 | Déniz O Bueno G Salido J | 2011 | Pattern Recognition Letters2011,32,12: | 1 |
| 5 | lncidence risk f&ctors &nd influence on surviv&l of infectious complic&tion in liver tr&nspl&ntation显示文摘 | Ech&niz A Pita S Otero A | 2003 | Enferm Infect Uicrobid Olin2003,21,5: | 1 |
| 6 | Microbial aetiology of community-acquired pneumonia and its relation to severity显示文摘 | Cillóniz C Ewig S Polverino E | | 0,,: | 1 |
| 7 | Imaging of the spleen in malaria 显示文摘 | Ferrer M Martin-Jaular L De Niz M | 2014 | Parasitol Int2014,63,: | 1 |
| 8 | Altered nitric oxide metabolism and increased oxygen free radical activity in lead-induced hypertension: effect of lazaroid therapy显示文摘 | Vaziri N D Ding Y Niz | 1997 | Kidney Int1997,52,4: | 1 |
| 9 | ThenovelBH-3mimeticapogossypoloneinducesBeclin-1-andROS-mediatedautophagyinhumanhepato-cellularcarcinomacells显示文摘 | ChengP NiZ DaiX etal | 2013 | CellDeathDis2013,4,: | 1 |
| 10 | Dichotic listening revisited: Trial-by-trial ERP analyses reveal intra- and interhemispheric differences显示文摘 | Onur Bayaz?t Adile ?niz Constanze Hahn Onur Güntürkün Murat ?zg?ren | 2008 | Neuropsychologia2008,,2: | 1 |
| 11 | On the use of posterior regret F-minimax actions to obtain credibility premiums显示文摘 | G6mez-D~niz E P~rez-S~nehez J M V~zquez-Polo F J | 2006 | Insurance: Mathematics and Economics2006,39,1: | 1 |
| 12 | Improving Artificial Neural Network with a Pruning Methodology and Genetic Algorithms for Their Application in Microbial Growth Prediction in Foods 显示文摘 | GARCIA-GIMENO R M HERVAS-MATINEZ C DE SILO- NIZ I | 2002 | International Journal of Food Microbiology2002,72,: | 1 |
| 13 | Serum Lip opolysaccharide Binding Protein in Endotoxemic Patients with Inflammatory Bowel Disease显示文摘 | O'scar Pastor Rojo Antonio Lo'pez San Roma'n Eduardo Albe' niz Arbizu | 2007 | In- flamm Bowel Dis2007,13,: | 1 |
| 14 | Review on modeling anti-antibody responses to monoclonal antibodies显示文摘 | Gómez-Mantilla JD Trocóniz IF Parra-Guillén Z | 2014 | J Pharmacokinet Pharmacodyn2014,41,5: | 1 |
| 15 | First report about the mode of action of combined butafosfan andcyanocobalamin on hepatic metabolism in nonketotic early lactating cows显示文摘 | KREIPE L De NIZ A BRUCKMAIER R M | 2011 | J Dairy Sci2011,94,10: | 1 |
| 16 | Microbial aetiology of community- acquired pneumonia and its relation to severity 显示文摘 | Cillo'niz C Ewig S Polverino E | 2011 | Thorax2011,66,4: | 1 |
| 17 | A portfolio approach to procurement contracts显示文摘 | Martínez-de-Albéniz V Simchi-Levi D | 2005 | Production and Operations Management2005,14,: | 1 |
| 18 | Bound aroma compounds in tobacco smoke condensate 显示文摘 | Kapfer G F Niz S Drawert F | 1989 | J Zleben Unters Forsch1989,188,: | 1 |
| 19 | Pharmacokinetic/pharmacodynamic evaluation of amoxicillin,amoxicillin/clavulanate and ceftriaxone in the treatment of paediatric acute otitis media in Spain显示文摘 | Isla A Trocóniz IF Canut A | 2011 | Enfermedades Infecciosas y Microbiología Clínica2011,,: | 1 |
| 20 | Optimal inventory policies when purchase price and demand are stochastic显示文摘 | Berling P Martínez-de-Albéniz V | 2011 | Operations Research2011,59,1: | 1 |