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1Endoscopic anti-reflux therapy for gastroesophageal reflux disease显示文摘Gastroesophageal reflux disease has an increasing incidence and prevalence worldwide.A significant proportion of patients have a suboptimal response to proton pump inhibitors or are unwilling to take lifelong medication due to concerns about long-term adverse effects.Endoscopic anti-reflux therapies offer a minimally invasive option for patients unwilling to undergo surgical treatment or take lifelong medication.The best candidates are those with a good response to proton pump inhibitors and without a significant sliding hiatal hernia.Transoral incisionless fundoplication and nonablative radiofrequency are the techniques with the largest body of evidence and that have been tested in several randomized clinical trials.Band-assisted ligation techniques,anti-reflux mucosectomy,antireflux mucosal ablation,and new plication devices have yielded promising results in recent noncontrolled studies.Nonetheless,the role of endoscopic procedures remains controversial due to limited long-term and comparative data,and no consensus exists in current clinical guidelines.This review provides an updated summary focused on the patient selection,technical details,clinical success,and safety of current and future endoscopic anti-reflux techniques.Enrique Rodríguez de Santiago Eduardo Albéniz Fermin Estremera-Arevalo Carlos Teruel Sanchez-Vegazo Vicente Lorenzo-Zúñiga 2021World Journal of Gastroenterology2021,27,39:9
2Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation显示文摘AIM:To evaluate the long-term results of conventional chemoradiotherapy and laparoscopic mesorectal excision in rectal adenocarcinoma patients without adjuvant therapy.METHODS:Patients with biopsy-proven adenocarcinoma of the rectum staged cT3-T4 by endoscopic ultrasound or magnetic resonance imaging received neoadjuvant continuous infusion of 5-fluorouracil for five weeks and concomitant radiotherapy.Laparoscopic surgery was planned after 5-8 wk.Patients diagnosed with ypT0N0 stage cancer were not treated with adjuvant therapy according to the protocol.Patients with ypT1-2N0 or ypT3-4 or N+were offered 5-fluorouracil-based adjuvant treatment on an individual basis.An external cohort was used as a reference for the findings.RESULTS:One hundred and seventy six patients were treated with induction chemoradiotherapy and 170underwent total mesorectal excision.Cancer staging of ypT0N0 was achieved in 26/170(15.3%)patients.After a median follow-up of 58.3 mo,patients withypT0N0 had five-year disease-free and overall survival rates of 96%(95%CI:77-99)and 100%,respectively.We provide evidence about the natural history of patients with localized rectal cancer achieving a complete response after preoperative chemoradiation.The inherent good prognosis of these patients will have implications for clinical trial design and care of patients.CONCLUSION:Withholding adjuvant chemotherapy after complete response following standard neoadjuvant chemoradiotherapy and laparoscopic mesorectal excision might be safe within an experienced multidisciplinary team.Xabier García-Albéniz Rosa Gallego Ralf Dieter Hofheinz Gloria Fernández-Esparrach Juan Ramón Ayuso-Colella Josep Antoni Bombí Carles Conill Miriam Cuatrecasas Salvadora Delgado Angels Ginés Rosa Miquel Mario Pagés Estela Pineda Verónica Pereira Aarón Sosa Oscar Reig Iván Victoria Luis Feliz Antonio María de Lacy Antoni Castells Iris Burkholder Andreas Hochhaus Joan Maurel 2014World Journal of Gastroenterology2014,20,42:5
3Tardive dyskinesia in 2 patients treatexl with ziprasidone显示文摘Ananth J Burgoyne KS Niz D 2004J Psychiatry Nettrosci2004,29,6:1
4Face recognition using histograms of oriented gradients显示文摘Déniz O Bueno G Salido J 2011Pattern Recognition Letters2011,32,12:1
5lncidence risk f&ctors &nd influence on surviv&l of infectious complic&tion in liver tr&nspl&ntation显示文摘Ech&niz A Pita S Otero A 2003Enferm Infect Uicrobid Olin2003,21,5:1
6Microbial aetiology of community-acquired pneumonia and its relation to severity显示文摘Cillóniz C Ewig S Polverino E 0,,:1
7Imaging of the spleen in malaria 显示文摘Ferrer M Martin-Jaular L De Niz M 2014Parasitol Int2014,63,:1
8Altered nitric oxide metabolism and increased oxygen free radical activity in lead-induced hypertension: effect of lazaroid therapy显示文摘Vaziri N D Ding Y Niz 1997Kidney Int1997,52,4:1
9ThenovelBH-3mimeticapogossypoloneinducesBeclin-1-andROS-mediatedautophagyinhumanhepato-cellularcarcinomacells显示文摘ChengP NiZ DaiX etal 2013CellDeathDis2013,4,:1
10Dichotic listening revisited: Trial-by-trial ERP analyses reveal intra- and interhemispheric differences显示文摘Onur Bayaz?t Adile ?niz Constanze Hahn Onur Güntürkün Murat ?zg?ren 2008Neuropsychologia2008,,2:1
11On the use of posterior regret F-minimax actions to obtain credibility premiums显示文摘G6mez-D~niz E P~rez-S~nehez J M V~zquez-Polo F J 2006Insurance: Mathematics and Economics2006,39,1:1
12Improving Artificial Neural Network with a Pruning Methodology and Genetic Algorithms for Their Application in Microbial Growth Prediction in Foods 显示文摘GARCIA-GIMENO R M HERVAS-MATINEZ C DE SILO- NIZ I 2002International Journal of Food Microbiology2002,72,:1
13Serum Lip opolysaccharide Binding Protein in Endotoxemic Patients with Inflammatory Bowel Disease显示文摘O'scar Pastor Rojo Antonio Lo'pez San Roma'n Eduardo Albe' niz Arbizu 2007In- flamm Bowel Dis2007,13,:1
14Review on modeling anti-antibody responses to monoclonal antibodies显示文摘Gómez-Mantilla JD Trocóniz IF Parra-Guillén Z 2014J Pharmacokinet Pharmacodyn2014,41,5:1
15First report about the mode of action of combined butafosfan andcyanocobalamin on hepatic metabolism in nonketotic early lactating cows显示文摘KREIPE L De NIZ A BRUCKMAIER R M 2011J Dairy Sci2011,94,10:1
16Microbial aetiology of community- acquired pneumonia and its relation to severity 显示文摘Cillo'niz C Ewig S Polverino E 2011Thorax2011,66,4:1
17A portfolio approach to procurement contracts显示文摘Martínez-de-Albéniz V Simchi-Levi D 2005Production and Operations Management2005,14,:1
18Bound aroma compounds in tobacco smoke condensate 显示文摘Kapfer G F Niz S Drawert F 1989J Zleben Unters Forsch1989,188,:1
19Pharmacokinetic/pharmacodynamic evaluation of amoxicillin,amoxicillin/clavulanate and ceftriaxone in the treatment of paediatric acute otitis media in Spain显示文摘Isla A Trocóniz IF Canut A 2011Enfermedades Infecciosas y Microbiología Clínica2011,,:1
20Optimal inventory policies when purchase price and demand are stochastic显示文摘Berling P Martínez-de-Albéniz V 2011Operations Research2011,59,1:1
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