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| 1 | Correlation of serum leptin levels with anthropometric and metabolic parameters and biochemical liver function in Chinese patients with chronic hepatitis C virus infection显示文摘AIM: To determine serum leptin levels and investigate their correlations with anthropometric and metabolic parameters and biochemical liver function in patients with chronic hepatitis C virus (HCV) infection and their potential clinical implications.METHODS: Forty-two chronic HCV-infected patients without anti-viral treatment were enrolled in this study, 30 patients had chronic hepatitis C, 10 had cirrhosis, and 2 had hepatocellular carcinoma (HCC). Thirty age- and sex-matched healthy individuals served as controls. Serum leptin levels were determined by ELISA. The biochemical liver function and serum lipids were determined at the same time. The height and body weight of patients and controls were measured, and body mass index (BMI) and body fat were calculated simultaneously. The correlations of serum leptin levels with anthropometric and metabolic parameters and biochemical liver function were assessed statistically.RESULTS: The mean of serum leptin levels in patients with chronic hepatitis C, HCV-associated cirrhosis, HCVassociated HCC and control groups was (6.13±3.94),(5.25±4.21), (4.17±0.28), and (3.59±3.44) ng/mL, respectively. The serum leptin level in patients with chronic hepatitis C was significantly higher than that in controls. The serum leptin levels between cirrhotic patients and controls and between male and female cirrhotic patients had no significant difference. Serum leptin levels were positively-correlated with body fat, BMI, and apolipoprotein B (Apo B) in patients with chronic HCV infection. The serum alanine aminotransferase (ALT) levels were closelycorrelated with BMI in patients with chronic hepatitis C. CONCLUSION: HCV infection interferes with fat and lipid metabolism in patients with chronic HCV infection and leptin may play a role in hepatosteatosis. | Zheng-WenLiu NiZhang Qun-YingHan Jun-TaoZeng Yong-LieChu Jian-MingQiu Ya-WenWang Lie-TingMa xiao-Qinwang | 2005 | World Journal of Gastroenterology2005，11，22： | 4 |
| 2 | Sequential changes of serum ferritin levels and their clinical significance in lamivudine-treated patients with chronic viral hepatitis B显示文摘AIM: To study the sequential changes of serum ferritin levels in lamivudine-treated patients with chronic viral hepatitis B and the clinical implications. METHODS: Thirty-eight patients with chronic viral hepatitis B were prospectively studied during their treatment with lamivudine. Each patient received 100 mg oral lamivudine daily for 12 mo, and was observed and tested for blood biochemistry and hepatitis B virus (HBV) DNA levels and serum ferritin levels at baseline and at 3, 6 and 12 mo during the treatment. Serum HBV DNA levels were quantitatively determined using fluorescent quantitative polymerase chain reaction (FQ-PCR), and serum ferritin levels were measured by radioimmunoassay. The sequential changes of serum ferdtin levels and their relationships with virological, serological and biochemical responses in the patients were analyzed. RESULTS: All the patients had a baseline HBV DNA level higher than 1×10^7 copies/L as determined by FQ-PCR and positive HBsAg and HBeAg and abnormal ALT levels. At the end of the 12-mo treatment, 19 of the 38(50.00%) patients had undetectable serum HBV DNA levels by FQ-PCR, and 12(31.58%) became negative for serum HSeAg and 10(26.32%) had seroconversion from HBeAg to HBeAb. Nineteen out of the 38(50.00%) patients had biochemically normal ALT levels after 12-mo lamivudine treatment. Sequential determination showed bhat lamivudine treatment significantly reduced ferritin levels in chronic hepatitis B patients. When the patients were divided into different groups according to their posttreatment virological, serological and biochemical responses for analysis of the sequential changes of ferritin levels, it was found bhat the decrease of ferritin levels in HBV DNA-negative group was significantly more obvious than that in HBV DNApositive group at 6 mo during the treatment (P=-0.013). Consecutive comparisons showed that ferritin levels at 3 mo of treatment were obviously decreased as compared with the baseline levels (P<0.05) in HBeAg-negative group, and the decrease of serum ferritin levels in patients with normalized ALT was more significant than that in patients with abnormal ALT at the end of the 12-mo treatment (P=0.048). CONCLUSION: Lamivudine treatment can reduce the serum ferritin levels in chronic viral hepatitis B patients and decreases of ferdtin levels can be more significant in patients exhibiting virological, serological and biochemical responses, indicating that dynamic observation of serum ferritin levels in patients with chronic viral hepatitis B during lamivudine treatment might be helpful for monitoring and predicting patients' responses to the therapy. | Zheng-WenLiu Qun-YingHan NiZhang WenKang | 2004 | World Journal of Gastroenterology2004，10，7： | 4 |
| 3 | Removal of baseline wander from ECG signal based on a statistical weighted moving average filter显示文摘Baseline wander is a common noise in electrocardiogram (ECG) results.To effectively correct the baseline and to preserve more underlying components of an ECG signal,we propose a simple and novel filtering method based on a statistical weighted moving average filter.Supposed a and b are theminimum and maximum of all sample values within a moving window,respectively.First,the whole region [a,b] is divided into M equal sub-regions without overlap.Second,three sub-regions with the largest sample distribution probabilities are chosen (except M<3) and incorporated into one region,denoted as [a 0,b 0 ] for simplicity.Third,for every sample point in the moving window,its weight is set to 1 if its value falls in [a 0,b 0 ];otherwise,its weight is 0.Last,all sample points with weight 1 are averaged to estimate the baseline.The algorithm was tested by simulated ECG signal and real ECG signal from www.physionet.org.The results showed that the proposed filter could more effectively extract baseline wander from ECG signal and affect the morphological feature of ECG signal considerably less than both the traditional moving average filter and wavelet package translation did. | Xiao HU Zhong XIAO NiZHANG | 2011 | Journal of Zhejiang University-Science C(Computers and Electronics)2011，12，5： | 3 |
| 4 | 东京之眼显示文摘1.电影
<东京之眼>不是很好的电影.对我来说,好电影不让人感伤,它只摧毁. | nizhange | 2001 | 青年作家2001，，5： | 0 |
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