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| 1 | Effect of preoperative biliary drainage on outcome of classical pancreaticoduodenectomy显示文摘AIM: To investigate the role of preoperative biliary drainage (PBD) in the outcome of classical pancreaticodu odenectomy. METHODS: A 10-year retrospective data analysis was performed on patients (n = 48) undergoing pancreaticoduodenectomy from March 1994 to March 2004 in department of surgery at SMS medical college, Jaipur, India. Demographic variables, details of preoperative stenting, operative procedure and post operative complications were noted. RESULTS: Preoperative biliary drainage was performed in 21 patients (43.5%). The incidence of septic complications was significantly higher in patients with biliary stent placement (P < 0.05, 0 vs 4). This group of patients also had a significantly higher minor biliary leak rate. Mortality and hospital stay in each group was comparable. CONCLUSION: Within this study population the use of PBD by endoscopic stenting was associated with a high incidence of infective complications. These findings do not support the routine use of biliary stenting in patients prior to pancreatico-duodenectomy. | Chandra Shekhar Bhati Chandrashekhar Kubal Pankaj Kumar Sihag Ankur Atal Gupta Raj Kamal Jenav Nicholas G Inston Jagdish M Mehta | 2007 | World Journal of Gastroenterology2007，13，8： | 12 |
| 2 | Cytoplasmic expression of p27^(kip1) is associated with a favourable prognosis in colorectal cancer patients显示文摘AIM: To evaluate the prognostic significance of p27kip1 in colorectal cancer patients. METHODS: Cytoplasmic and nuclear p27kip1 expression was evaluated in 418 colorectal cancers using tissue microarrays. Data were associated with known patient and tumor variables and long-term patient outcomes, providing further insight into the mechanisms by which p27kip1 may influence tumor development. RESULTS: Nuclear and cytoplasmic p27Kip1 expressions were detected in 59% and 19% of tumors respectively. Cytoplasmic p27Kip1 was almost invariably associated with positive nuclear p27Kip1 expression. Neither case correlat- ed with known clinical or pathological variables, includ- ing tumor stage, grade or extramural vascular invasion. Furthermore, nuclear p27kip1 expression had no impact on survival. However, we identified a significant correla- tion between expression of cytoplasmic p27kip1 and longer disease-specific survival times. On multivariate analysis, TNM stage and extramural vascular invasion were highly significant independent prognostic factors, with positive cytoplasmic p27 expression showing a trend towards im- proved patient survival (P = 0.059).CONCLUSION: These findings support the recent evi- dence that cytoplasmic p27kip1 has a distinct and impor- tant biological role that can influence tumor outcome. | Nicholas FS Watson Lindy G Durrant John H Scholefield Zahra Madjd Duncan Scrimgeour Ian Spendlove Ian O Ellis Poulam M Patel | 2006 | World Journal of Gastroenterology2006，12，39： | 3 |
| 3 | 澳大利亚初级保健诊所新发腰背痛患者的预后:起始队列研究显示文摘目的估计初级保健诊所内新发腰背痛患者的1年预后,并确定其预后因素。设计1年随访队列研究。地点澳大利亚悉尼的初级保健诊所。参试者初级保健诊所接诊的973例非特异性腰背痛连续患者(平均年龄43.3岁,男性54.8%)。该起始队列患者腰背痛时间不足两周,征集自170名全科医生、理疗师或按摩师诊所。主要评估指标参试者完成基线调查问卷后,分别于初次就诊后6周、3个月和21个月时复查评估。评估内容包括:工作恢复情况、功能恢复情况和疼痛消失情况。潜在预后因素与恢复所需时间的关联性用Cox回归建模分析。结果12个月随访率〉97%。基线时工作能力下降的患者半数在14天内恢复了以前的工作状态(95%可信区间11-17天),83%在3个月内恢复。残疾(中位恢复时间31天,25-37天)和疼痛(中位58天,52-63天)则需要较长的时间才能恢复。只有72%的受试者于基线访问后12个月获得完全康复。高龄、赔偿诉讼、疼痛较重、就诊前腰背痛时间较长、就诊前因疼痛活动减少天数较多、抑郁情绪以及预期危险持续与所需恢复时问较长相关。结论在这个急性腰背痛初级保健患者队列,患者的预后并不像临床指南声称的那样乐观。多数患者的恢复缓慢。近三分之一的患者在腰背痛发作后1年尚未恢复。 | Nicholas Henschke Christopher G Maher Kathryn M Refshauge Robert D Herbert Robert G Cumming Jane Bleasel John York Anurina Das James H McAuley 蓝恭涛(译) | 2008 | 英国医学杂志中文版2008，11，6： | 2 |
| 4 | Perioperative risk factors associated with delayed graft function following deceased donor kidney transplantation:A retrospective,single center study显示文摘BACKGROUND There is an abundant need to increase the availability of deceased donor kidney transplantation(DDKT)to address the high incidence of kidney failure.Challenges exist in the utilization of higher risk donor organs into what appears to be increasingly complex recipients;thus the identification of modifiable risk factors associated with poor outcomes is paramount.AIM To identify risk factors associated with delayed graft function(DGF).METHODS Consecutive adults undergoing DDKT between January 2016 and July 2017 were identified with a study population of 294 patients.The primary outcome was the occurrence of DGF.RESULTS The incidence of DGF was 27%.Under logistic regression,eight independent risk factors for DGF were identified including recipient body mass index≥30 kg/m^(2),baseline mean arterial pressure<110 mmHg,intraoperative phenylephrine administration,cold storage time≥16 h,donation after cardiac death,donor history of coronary artery disease,donor terminal creatinine≥1.9 mg/dL,and a hypothermic machine perfusion(HMP)pump resistance≥0.23 mmHg/mL/min.CONCLUSION We delineate the association between DGF and recipient characteristics of preinduction mean arterial pressure below 110 mmHg,metabolic syndrome,donorspecific risk factors,HMP pump parameters,and intraoperative use of phenylephrine. | Nicholas V Mendez Yehuda Raveh Joshua J Livingstone Gaetano Ciancio Giselle Guerra George W Burke III Vadim B Shatz Fouad G Souki Linda J Chen Mahmoud Morsi Jose M Figueiro Tony M Ibrahim Werviston L DeFaria Ramona Nicolau-Raducu | 2021 | World Journal of Transplantation2021，11，4： | 2 |
| 5 | Plant antitumor agents(29): Synthesis and biological activity of ring D and ring E modified analogues of camptothecin显示文摘 | Nicholas A W Wani M C Manikumar G | 1990 | J Med Chem1990，33，3： | 1 |
| 6 | An evaluation of the partial transient liquid phase bonding of Si3N4 using Au coated Ni-22Cr foils显示文摘 | Ceccone G Nicholas M G Peteves S D | 1996 | Acta Mater1996，44，2： | 1 |
| 7 | Total knee arthoplasty in patients with a prior fracture of the tibial plateau显示文摘 | Nicholas G Weiss M Javad F | 2003 | J Bone Joint Surg Am2003，85，5： | 1 |
| 8 | Oceanapiside, an antifungal bis - ct, w - amino alcohol glycoside from the ma- rine sponge oceanapia phiUipensis 显示文摘 | Nicholas G M Hong T W Molinski T F | 1999 | J Nat Prod1999，62，12： | 1 |
| 9 | Changes in renal calculi com- position in the west mid|ands:A 20 year experience显示文摘 | Nicholas G Phillip P David M | 2013 | Int J Surg2013，11，8： | 1 |
| 10 | The wetting of alumna by copper alloyed with titanium and other elements 显示文摘 | CECCONE G NICHOLAS M G PETEVES S D | 1996 | Mater SciLett1996，44，2： | 1 |
| 11 | Preparation, characterization and scanned conductance microscopy studies of DNA-templated one-dimensional copper nanostructures 显示文摘 | Scott M D Watson Nicholas G W | 2010 | Langmuir2010，26，3： | 1 |
| 12 | The safety of incidental appendectomy at the time of abdominal hysterectomy显示文摘 | Emery M Salom Dana Schey Manuel Pe?alver Orlando Gómez-Mar??n Nicholas Lambrou Zoyla Almeida Luis Mendez | 2003 | American Journal of Obstetrics and Gynecology2003，，6： | 1 |
| 13 | Development and validation of an air-to-beef food chain model for dioxin-like compounds 显示文摘 | Lohmann R Robert G M L Nicholas J L | 2000 | Science of The Total Environment2000，，156： | 1 |
| 14 | Pres- sure welding by rolling at elevated temperatures显示文摘 | VAIDYANATH L R NICHOLAS M G MILNER D R | 1959 | British WeldJournal1959，6，： | 1 |
| 15 | The brazing of Si3N4 with Ni-Cr-Si alloys显示文摘 | CECCONE G NICHOLAS M G PETEVES S D | 1995 | Journal of the European Ceramic Society1995，15，： | 1 |
| 16 | Holocene periodicity in North Atlantic climate and deep-ocean flow south of Iceland显示文摘 | Giancarlo G B Nicholas M I | 1999 | Nature1999，397，6719： | 1 |
| 17 | Modeling impactof small kansas landfills on underlying aquifers显示文摘 | SOPHOCLEOUS M NICHOLAS G S STOTTS M | 1996 | Environ Eng-ASCE1996，122，： | 1 |
| 18 | Tissue transglutaminase mediates the pro‐malignant effects of oncostatin M receptor over‐expression in cervical squamous cell carcinoma显示文摘 | Maria M Caffarel Anasuya Chattopadhyay Angela M Araujo Julien Bauer Cinzia G Scarpini Nicholas Coleman | 2013 | J Pathol2013，，2： | 1 |
| 19 | The role of nitric oxide synthase isoforms in extrahepatic portal hypertension: studies in gene-knockout mice显示文摘 | Nicholas G Theodorakis Yi-ning Wang Nicholas J Skill Matthew A Metz Paul A Cahill Eileen M Redmond James V Sitzmann | 2003 | Gastroenterology2003，，5： | 1 |
| 20 | Cellulosic hydrolysate toxicity and tolerance mechanisms in Escherichia coli 显示文摘 | TIRZAH Y M NICHOLAS R S RYAN T G | 2009 | Biotechnol for Biofuels2009，2，： | 1 |
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