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| 1 | 基于NMR的代谢组学方法最新进展及应用(英文)显示文摘代谢组学的定义“对病理/生理刺激以及基因改变时生物体系动态的代谢响应进行多参数的定量测量”已被广泛接受.本文对代谢组学研究的最新进展及其在系统生物学中所发挥的作用进行了综述.在代谢组学方法研究方面,着重讨论了现代NMR技术的进展及其对代谢组学所产生的影响,同时也包括用于分离的HPLC及其与质谱的连用技术.对代谢组学广泛应用的概述,主要包括:对正常生理变化的新认识;药物和其他外源性化学物质的副作用;外源性物质对环境污染的影响以及逐渐增多的代谢组学方法在疾病检测中应用. | LINDON J C HOLMES E NICHOLSON J K | 2006 | 波谱学杂志2006，23，1： | 10 |
| 2 | The SOCS proteins:A new family of negative regulators of signal transduction 显示文摘 | Nicholson S E Hilton D J | 1998 | J Leukoc Biol1998，63，6： | 3 |
| 3 | Transanal total mesorectal excision:a valid option for rectal cancer?显示文摘Low anterior resection can be a challenging operation, especially in obese male patients and in particular after radiotherapy. Transanal total mesorectal excision(Ta TME) might offer technical advantages over laparoscopic or open approaches particularly for tumors in the distal third of the rectum. The aim of this article is to review the current experience with Ta TME. The limits and future developments are also explored. Although the experience with Ta TME is still limited, it might be a promising alternative to laparoscopic TME, especially for difficult cases where laparoscopy is too demanding. The preliminary data on complications and short-term oncological outcomes are good, but also emphasize the importance of careful patient selection. Finally, there is a need for large-scale trials focusing on long-term outcomes and oncological safety before widespread adoption can be recommended. | Nicolas C Buchs Gary A Nicholson Frederic Ris Neil J Mortensen Roel Hompes | 2015 | World Journal of Gastroenterology2015，21，41： | 3 |
| 4 | 1400W reduces ischemia reperfusion injury in an ex-vivo porcine model of the donation after circulatory death kidney donor显示文摘AIM: To investigate the effects of 1400W-a selective inducible nitric oxide synthase(iN OS) inhibitor in a model of donation after circulatory death(DCD) kidneys. METHODS: Porcine kidneys were retrieved after 25 min warm ischemia. They were then stored on ice for 18 h before being reperfused ex vivo with oxygenated autologous blood on an isolated organ perfusion system. The selective i NOS inhibitor 1400W(10 mg/kg) was administered before reperfusion(n = 6) vs control group(n = 7). Creatinine(1000 μmol/L) was added to the system, renal and tubular cell function and the level of ischemia reperfusion injury were assessed over 3 h of reperfusion using plasma, urine and tissue samples. RESULTS: Kidneys treated with 1400 W had a higher level of creatinine clearance(CrC l) [area under the curve(AUC) CrC l: 2.37 ± 0.97 mL /min per 100 g vs 0.96 ± 0.32 mL /min per 100 g, P = 0.004] and urine output [Total: 320 ± 96 mL vs 156 ± 82 mL, P = 0.008]. There was no significant difference in levels of fractional excretion of sodium(AUC, Fr ex Na+: Control, 186.3% ± 81.7%.h vs 1400 W, 153.4% ± 12.1%.h, P = 0.429). Levels of total protein creatinine ratio were significantly lower in the 1400 W group after 1 h of reperfusion(1h Pr/Cr: 1400 W 9068 ± 6910 mg/L/mmol/L vs Control 21586 ± 5464 mg/L/mmol/L, P = 0.026). Levels of 8-isoprostane were significantly lower in the 1400 W group [8-iso/creatinine ratio: Control 239 ± 136 pg/L/mmol/L vs 1400 W 139 ± 47 pg/L/mmol/L, P = 0.041].CONCLUSION: This study demonstrated that 1400 W reduced ischaemia reperfusion injury in this porcine kidney model of DCD donor. Kidneys had improved renal function and reduced oxidative stress. | Sarah A Hosgood Phillip J Yates Michael L Nicholson | 2014 | World Journal of Transplantation2014，4，4： | 2 |
| 5 | Metabonomics: a platform for studying drug toxicity and gene function显示文摘 | Nicholson JK Connelly J Lindon JC Holmes E | 2002 | Nat Rev Drug Discov2002，1，2： | 2 |
| 6 | RF impedance of power lines and line impedance stabilization networks in conducted interference measurements 显示文摘 | Nicholson J R Malack A | 1973 | IEEE Transactions on Electromagnetic Compatibility1973，25，1： | 2 |
| 7 | Human ICE/CED-3 Protease Nomenclature显示文摘 | Emad S Alnemri David J Livingston Donald W Nicholson Guy Salvesen Nancy A Thornberry Winnie W Wong Junying Yuan | 1996 | Cell1996，，2： | 2 |
| 8 | Treatment of children with medulloblastomas with reduceddose craniospinal radiation therapy and adjuvant chemotherapy:a Children's Cancer Group Study显示文摘 | Goldwein J Nicholson HS | 1999 | J Clin Oncol1999，17，： | 1 |
| 9 | Angiogenesis inhibitors specific for methionine aminopeptidase 2 as drugs for malaria and leishmaniasis显示文摘 | Zhang P Nicholson DE Bujnick J | 2002 | J Biol Med Sci2002，9，1： | 1 |
| 10 | Destruction of Cyanobacterial Peptide Hepatotoxins by Chlorine and Chloramine显示文摘 | Nicholson B C Rositano J Burch M D | 1994 | Water Res1994，28，： | 1 |
| 11 | Finding the shortest route between two points in a network显示文摘 | Nicholson T A J | 1966 | The Computer Journal1966，，3： | 1 |
| 12 | Effect of fluid flow characteristics on nozzle blockage in aluminium- killed steels显示文摘 | Wilson F G Heesom M J Nicholson A | 1987 | Ironmaking and Steelmaking1987，14，6： | 1 |
| 13 | Toxicological applications of magnetic resonance显示文摘 | LINDON J C HOLMES E NICHOLSON J K | | 0，，： | 1 |
| 14 | An Inventory of Heavy Metals Inputs to Agricultural Soils in England and Wales显示文摘 | Nicholson F A Smith S R Alloway B J | 2003 | The Science of the Total Environment2003，311，： | 1 |
| 15 | An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy 显示文摘 | Coen M Lenz E M Nicholson J K | 2003 | Chem Res Toxicol2003，16，3： | 1 |
| 16 | Application of chemometrics to 1H NMR spectroscopic data to investigate a relationship between human serum metabolic profiles and hypertension显示文摘 | BRINDLE J T NICHOLSON J K SCHOFIELD P M | 2003 | Analyst2003，128，1： | 1 |
| 17 | Metabonomics: a platform for studying drug toxicity and gene function显示文摘 | Nicholson J K Connelly J Lindon J C | 2002 | Nat Rev Drug Discov2002，1，2： | 1 |
| 18 | EGFR and cancer prognosis显示文摘 | Nicholson R I Gee J M Harper M E | 2001 | Eur J Cancer2001，37，4： | 1 |
| 19 | Metabonomics: a platform for studying drug toxicity and gene function显示文摘 | Nicholson JK Connelly J Lindon JC | 2002 | Nat Rev Drug Discov2002，1，2： | 1 |
| 20 | Ozonation of NOM and algal toxins in four treated waters显示文摘 | Rositano J Newcombe G Nicholson B | 2001 | Water Research2001，35，1： | 1 |
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