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| 1 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 2 | 基于NMR的代谢组学方法最新进展及应用(英文)显示文摘代谢组学的定义“对病理/生理刺激以及基因改变时生物体系动态的代谢响应进行多参数的定量测量”已被广泛接受.本文对代谢组学研究的最新进展及其在系统生物学中所发挥的作用进行了综述.在代谢组学方法研究方面,着重讨论了现代NMR技术的进展及其对代谢组学所产生的影响,同时也包括用于分离的HPLC及其与质谱的连用技术.对代谢组学广泛应用的概述,主要包括:对正常生理变化的新认识;药物和其他外源性化学物质的副作用;外源性物质对环境污染的影响以及逐渐增多的代谢组学方法在疾病检测中应用. | LINDON J C HOLMES E NICHOLSON J K | 2006 | 波谱学杂志2006，23，1： | 10 |
| 3 | 心房颤动——当今面临的挑战显示文摘在过去数年里,临床和科撞方面对心房颤动(房颤)的关注明显增加,有关这一论题的出版物数量迅速、稳定的增长就是证明。虽然已有一些新方法治疗遮一心律失常一但大多数房颤患者仍然不得不忍受这一心律失常,包括其不良后果和症状,房颤无疑是虽迫切需要有更好治疗方法的一种心律失常。为了达到这一目的,就需要更深刻地认识房颤的机制.以便开发直接影响这一基础病理生理机制的治疗措施。 | Olsson SB Hansson A Hedin E Holm M Ingemansson M Johansson R Meurling C Pehrson S Roijer A Yuan S 方丕华 | 1997 | 中华心律失常学杂志1997，1，1： | 3 |
| 4 | Cognitive and adaptive outcome in low-grade pediatric cerebellar astrocytomas: evidence of diminished cognitive and adaptive functioning in National Collaborative Research Studies (CCG 9891/POG 9130).显示文摘 | Beebe DW Ris MD Armstrong FD Fontanesi J Mulhern R Holmes E Wisoff JH | 2005 | 中国神经肿瘤杂志2005，3，3： | 3 |
| 5 | ‘Metabonomics’: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data显示文摘 | Nicholson JK Lindon JC Holmes E | 1999 | Xenobiotica1999，29，11： | 2 |
| 6 | Metabonomics: metabolic processes studied by NMR spectroscopy of biofluids显示文摘 | Lindon JC Nicholson JK Holmes E Everett JR | 2000 | Concepts Magn Reson2000，12，5： | 2 |
| 7 | Metabonomics: a platform for studying drug toxicity and gene function显示文摘 | Nicholson JK Connelly J Lindon JC Holmes E | 2002 | Nat Rev Drug Discov2002，1，2： | 2 |
| 8 | Metabonomic characterization of genetic variations in toxicological and metabolic responses using probabialistic neural networks显示文摘 | Holmes E Nicholson JK Tranter G | 2001 | Chem Res Toxicol2001，14，2： | 2 |
| 9 | Chemometric models for toxicity classification based on NMR spectra of biofluids显示文摘 | Holmes E Nicholls AW Lindon JC Connor SC Connelly JC Haselden JN | 2000 | Chem Res Toxicol2000，13，6： | 2 |
| 10 | An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk:ApfCD mouse显示文摘 | Gavaghan CL Holmes E Lenz E Wilson ID Nicholson JK | 2000 | FEBS Lett2000，484，3： | 2 |
| 11 | 与久坐者相比,职业运动员的肠道菌群在代谢组分,尤其是功能代谢水平上有所不同显示文摘目的有证据表明肠道菌群以及影响其结构和活性的因素在人类代谢、免疫和发育过程中发挥作用。我们曾报道,与久坐者相比,诸如职业运动员,配有相应饮食的极度体育活动者肠道菌群种属和代谢组分发生了改变。这次我们重点研究这些因素对菌群功能/代谢活动的影响,以进一步揭示运动者和久坐者间的差别。方法对专业国际橄榄球联盟球员(样本数为40例)和对照(样本数为46例)的肠道菌群进行代谢表型和功能宏基因组分析,并将结果与生活方式指标(比如饮食习惯)和临床评估指标(比如血清肌酸激酶)进行关联。结果与对照相比,运动员组中与肌肉更新和整体健康相关的信号通路(比如:氨基酸、抗生素生物合成和碳水化合物代谢)和肠道菌群代谢产物(比如:短链脂肪酸乙酸酯、丙酸酯和丁酸酯)有所增加。结论运动和久坐相比,其肠道菌群在宏基因组和代谢组学上比组织水平显示出更大差异,拓展了饮食.运动.肠道微生态模式新视野。 | Barton W Penney NC Cronin O Garcia-Perez I Molloy MG Holmes E Shanahan F Cotter PD O'Sullivan O 毛玲娜 宋震亚 | 2017 | 英国医学杂志中文版2017，20，7： | 2 |
| 12 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet . 2013 (9867)2013，，9867： | 2 |
| 13 | Chronic fatigue syndrome; H working case definition 显示文摘 | Holmes G P Kaplan J E Gantz N M | 1988 | Ann InternMed1988，108，： | 1 |
| 14 | The evolution of epidemic influenza 显示文摘 | Nelson M I Holmes E C | 2007 | Nat Rev Genet2007，8，3： | 1 |
| 15 | A Unified Approach to Clenshaw Summation and the Recursive Computation of Very High Degree and Order Normalized Associated Legendre Functions显示文摘 | Holmes S A Featherstone W E | 2002 | Journal of Geodesy2002，76，： | 1 |
| 16 | Thermophily in the Geobacteraceae: Geotherrnobacter ehrlichii gen nov, sp nov, a novel thermophilic member of the Geobacteraceae from the 'Bag City' hydrothermal vent显示文摘 | Kashefi K Holmes D E Baross J A | 2003 | Applied and Environmental Microbiology2003，69，： | 1 |
| 17 | ' Metabonomics' : understanding the met abolic responses of living systems to pathophysio logical stimuli via multivariate statistical analysis of biological NMR spectrosc-opic data 显示文摘 | Nicholson JK Lindon JC Holmes E | 1999 | Xenobiotica1999，29，1： | 1 |
| 18 | Comparison of to tal oral bioavailability and the lymphatic transport of halofantrine from three different unsaturated triglycerides in lymph-cannulated conscious rats 显示文摘 | Holm R Mtillertz A Christensen E | 2001 | Eur J Pharm Sci2001，14，4： | 1 |
| 19 | Linguistic symptoms in dementia of the Alzheimer type and their relation to linguistic symptoms of aphasia 显示文摘 | Holm H Migneus M Ahlsen E | 1994 | Scand J Logoped Phoniatr1994，19，： | 1 |
| 20 | Global existence theory for a generalized Ginzburg-Landau equation显示文摘 | DUAN J HOLMES P TITI E S | 1992 | Nonlinearity1992，，5： | 1 |
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