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| 1 | Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD) is a progressive disease of increasing public health concern.In western populations the disease has an estimated prevalence of 20%-40%,rising to 70%-90% in obese and type Ⅱ diabetic individuals.Simplistically,NAFLD is the macroscopic accumulation of lipid in the liver,and is viewed as the hepatic manifestation of the metabolic syndrome.However,the molecular mechanisms mediating both the initial development of steatosis and its progression through non-alcoholic steatohepatitis to debilitating and potentially fatal fibrosis and cirrhosis are only partially understood.Despite increased research in this field,the development of non-invasive clinical diagnostic tools and the discovery of novel therapeutic targets has been frustratingly slow.We note that,to date,NAFLD research has been dominated by in vivo experiments in animal models and human clinical studies.Systems biology tools and novel computational simulation techniques allow the study of large-scale metabolic networks and the impact of their dysregulation on health.Here we review current systems biology tools and discuss the benefits to their application to the study of NAFLD.We propose that a systems approach utilising novel in silico modelling and simulation techniques is key to a more comprehensive,better targeted NAFLD research strategy.Such an approach will accelerate the progress of research and vital translation into clinic. | Ciarán P Fisher Andrzej M Kierzek Nick J Plant J Bernadette Moore | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 2 | Interpreting diel hysteresis between soil respiration and temperature显示文摘 | Clairel P Nick N David R | 2011 | Global Change Biology2011，17，： | 1 |
| 3 | Regulation of osteoblastogenesis and osteoclastogenesis by the other reproductive hormones, Aetlvin and Inhibin 显示文摘 | NICKS K M PERRIEN D S AKEL N S | 2009 | Mol Cell Endocrinol2009，310，12： | 1 |
| 4 | Selective activation and functional significance of p38a mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils显示文摘 | NICK J A AVDI N J YOUNG S K | 1999 | J Clin Invest1999，103，6： | 1 |
| 5 | Towards the development of a chemical kinetic model for the homogeneous oxidation of mercury by chlorine species显示文摘 | REBECCA N S JOHN C K NICK M M | 2000 | Fuel Processing Technology2000，6566，： | 1 |
| 6 | Activation Of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide 显示文摘 | Nick JA Avdi N J Gerwins P | 1996 | J Immunol1996，156，12： | 1 |
| 7 | Synthesis, structural characterization and in vitro cytotoxicity of organotin (IV) : Derivatives of heterocyclic thioamides, 2-mercaptobenzothiazole, 5-chloro-2-mercaptobenzothiazole, 3-methyl-2- mercaptobenzothiazole and 2-mercapto-nicotinic acid 显示文摘 | Xanthopoulou M N Hadjikakou S K Nick H | 2003 | Inorganic and Analytical Chemistry2003，96，23： | 1 |
| 8 | Validity of SF-12 summary scores in a Greek general population显示文摘 | Nick K Evelina P Dimitris N | 2007 | Health and Quality of Life Outcomes2007，，5： | 1 |
| 9 | Towards the development of a chemical kinetic model for the homogeneous oxidation of mercury by chlorine species显示文摘 | Rebecca N Sliger John C Kramlich Nick M Marinov | 2000 | Fuel Processing Technology2000，6566，： | 1 |
| 10 | Towards the development of a chemical kinetic model for the homogeneous oxidation of mercury by chlorine species 显示文摘 | Sliger R N John C K Nick M M | 2000 | Fuel Processing Technolegy2000，6566，： | 1 |
| 11 | Superluminal and slow light propagation in a room-temperature solid显示文摘 | Matthew S B Nick N L Robert W B | 2003 | Science2003，301，： | 1 |
| 12 | Business at the Margins? Business Interests in Edge Urban Politics显示文摘 | Nick Phelps Parsons N Ballas D Dowling A | 2006 | International Journal of Urban and Regional Research2006，30，2： | 1 |
| 13 | Trust and Uncertainty:A Study of Bank Lending to Private SMEs in Vietnam 显示文摘 | Thanghang V N Ngoc T B Nick J F | 2006 | Asia Pacific Business Review2006，，4： | 1 |
| 14 | Production of methyl ester fuel from microalgae显示文摘 | Nick N Pete L | 1990 | Applied Biochemistry and Biotechnology1990，2425，1： | 1 |
| 15 | Towards the development of a chemical kinetic model for the homogeneous oxidation of mercury by chlorine species 显示文摘 | Sliger Rebecca N Kramlich John C Marinov Nick M | 2000 | Fuel Processing Technology2000，6566，： | 1 |
| 16 | Intelligent second-generation MES solutions for 300mm Fabs显示文摘 | Sukhi N Nick W | 2000 | Solid State Technology2000，43，6： | 1 |
| 17 | Social factors influencing the acquisition of antibiotics without prescription in Kerala State,south India显示文摘 | Rema DS Nick H Mark N | 2000 | Social Science & Medicine2000，50，： | 1 |
| 18 | Spacecraft vibration using pulse-width pulse-frequency modulated input shaper 显示文摘 | Song Gangbing Buck Nick V Agrawal Brij N | 1999 | Journal of Guidsnce Control and Dyamics1999，22，3： | 1 |
| 19 | lnvasive pneumococ- cal disease after routine pneumococc'al conjugate vaccination in chil- dren, England and Wales显示文摘 | Sham- N Ladhani Mary P E Slack Nick J Andrews Pauline A Waight Ray Borrow Elizabeth Miller | 2013 | Emerging infectious diseases2013，19，1： | 1 |
| 20 | A socio-economic comparison of hemodialysis and peritoneal dialysis in Greece显示文摘 | Nick K Dimitris N John M | 2005 | Int J Heahhcare Technology and Management2005，6，3： | 1 |
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