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| 1 | Parameters of a severe disease course in ulcerative colitis显示文摘AIM:To detect high risk patients with a progressive disease course of ulcerative colitis(UC) requiring immunosuppressive therapy(IT).METHODS:A retrospective,multicenter analysis of 262 UC patients from eight German tertiary inflammatory bowel disease centres was performed.Patients were divided into two groups depending on the patients need to initiate immunosuppressive therapy in the disease course.A comparison between the two groups was made with regard to demographics,clinical and laboratory parameters obtained within three months after UC diagnosis and the response to first medical therapy.Using this data,a prognostic model was established to predict the individual patients probability of requiring an immunosuppressive therapy.RESULTS:In 104(39.7%) out of 262 patients,UC therapy required an immunosuppressive treatment.Patients in this group were significantly younger at time of diagnosis(HR = 0.981 ± 0.014 per year,P = 0.009),and required significantly more often a hospitalisation(HR = 2.5 ± 1.0,P < 0.001) and a systemic corticosteroid therapy at disease onset(HR = 2.4 ± 0.8,P < 0.001),respectively.Response to steroid treatment was significantly different between the two groups of patients(HR = 5.2 ± 3.9 to 50.8 ± 35.6 compared to no steroids,P = 0.016 to P < 0.001).Furthermore,in the IT group an extended disease(HR = 3.5 ± 2.4 to 6.1 ± 4.0 compared to proctitis,P = 0.007 to P = 0.001),anemia(HR = 2.2 ± 0.8,P < 0.001),thrombocytosis(HR = 1.9 ± 1.8,P = 0.009),elevated C-reactive protein(CRP)(HR = 2.1 ± 0.9,P < 0.001),and extraintestinal manifestations in the course of disease(HR = 2.6 ± 1.1,P = 0.004) were observed.Six simple clinical items were used to establish a prognostic model to predict the individual risk requiring an IT.This probability ranges from less than 2% up to 100% after 5 years.Using this,the necessity of an immunosuppressive therapy can be predicted in 60% of patients.Our model can determine the need for an immunosuppressive drug therapy or if a 'watch and wait' approach is reasonable already early in the treatment course of UC.CONCLUSION:Using six simple clinical parameters,we can estimate the patients individual risk of developing a progressive disease course. | Andreas Stallmach Luisa Nickel Thomas Lehmann Bernd Bokemeyer Martin Bürger Dietrich Hüppe Wolfgang Kruis Susanna Nikolaus Jan C Preiss Andreas Sturm Niels Teich Carsten Schmidt | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 2 | A new signal adaptive approach to positive time- frequency distributions with suppressed interference terrns显示文摘 | Nickel R M Sang T H Williams W J | 1998 | ICASSP1998，，： | 1 |
| 3 | Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis 显示文摘 | Zhang H Cook J Nickel J | 2000 | Nat Biotechnol2000，18，8： | 1 |
| 4 | Adapting polyhedral properties from facility to hub location problems显示文摘 | HAMACHER H W LABB M NICKEL S | 2004 | Discrete Applied Mathematics2004，145，1： | 1 |
| 5 | Determination of barrier oxidation states in spin dependent tunneling structures 显示文摘 | Wang S X Nickel J H | 1999 | J Appl Phys1999，85，11： | 1 |
| 6 | The coat-mix procedure using carbon fillers 显示文摘 | LUHLEICH H DIAS F J NICKEL H | 1997 | Carbon1997，35，： | 1 |
| 7 | Asymmetrical dimethylarginine,inflammatory and metabolic parameters in women with polycystic ovary syndrome before and after metformin treatment显示文摘 | Hentling D Schulz H Nickel I | | 0，，： | 1 |
| 8 | Melatonin potentiates flavoneinduced apoptosis in human colon cancer cells by increasing the level of glycolytic end products显示文摘 | Wenzel U Nickel A Daniel H | 2005 | Int J Cancer2005，116，3： | 1 |
| 9 | Auchenorrhyncha communities as indicators of disturbance in grasslands ( Insecta Hemiptera) -a case study from the Elbe flood plains ( northern Germany) 显示文摘 | NICKEL H HILDEBRANDT J | 2003 | Agriculture Ecosystems & Environment2003，98，13： | 1 |
| 10 | Raman Spectroscopy of B-doped Microcrystalline Silicon Films显示文摘 | Saleh R Nickel N H | 2003 | Thin Solid Films2003，427，12： | 1 |
| 11 | Growth differentiation factor- 15 in idiopathic pulmonary arterial hypertension 显示文摘 | Nickel N Kempf T Tapken H | 2008 | Am J Respir Crit Care Med2008，178，： | 1 |
| 12 | Circulating levels of copeptin predict outcome in patients with pulmonary arterial hypertension显示文摘 | Nickel NP Lichtinghagen R Golpon H | 2013 | Respir Res2013，14，： | 1 |
| 13 | Identification of dialysis patients with panel-reactive memory T cells before kidney transplantation using an allogenie cell bank 显示文摘 | Andree H Nickel P Nasiadko C | 2006 | J Am Soc Nephrol2006，17，2： | 1 |
| 14 | Thermal stresses and deposition patterns in layered manufacturing显示文摘 | Nickel A H | 2001 | Materials Science and Engineering2001，317，： | 1 |
| 15 | Low-temperature MBE growth and characteristics of InP-based AllnAs/GalnAs MQW structures 显示文摘 | Kuenzel H Biermann K Nickel D | 2001 | Journal of Crystal Growth2001，，： | 1 |
| 16 | Immunoregulatory effects of the flavonol quereetin in vitro and in vivo显示文摘 | Nickel T Hanssen H Sisic Z e t a| | 2011 | Eur J Nutr2011，50，3： | 1 |
| 17 | Growth differentiation factor 15 in idiopathic pulmonary arterial hypertension显示文摘 | Nickel N Kempf T Tapken H Tongers J Laenger F Lehmann U | 2008 | Am J Respir Crit Care Med2008，178，： | 1 |
| 18 | Effects of the highaffinity corticotropinreleasing hormone receptor 1 antagonist R121919 in major depression: The first 20 patients treated显示文摘 | Zobel A W Nickel T Kunzel H E | 2000 | J Psychiatr Res2000，34，： | 1 |
| 19 | NIH consensus definition and classification of prostatitis显示文摘 | KRIEGER J N NYBERG h JR NICKEL J C | 1999 | JAMA1999，282，3： | 1 |
| 20 | State markers of depression in sleep EEG:dependency on druag and gender in patients treated with tianeptine or paroxetine显示文摘 | Murch H Nickel T Kunzel H | 2003 | Neuropsychopharma2003，28，3： | 1 |
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