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| 1 | 黄斑色素光学密度、中央黄斑厚度与体重指数的关系(英文)显示文摘目的:评估黄斑色素光学密度(MPOD)、中央黄斑厚度与体重指数(BMI)的关系。方法:这是一项在单一机构中进行比较的横断面研究。本研究共纳入210名符合入选标准的志愿者。使用黄斑色素筛选剂II对受试者MPOD进行测量。使用SD Cirrus OCT测量中央黄斑厚度。记录所有眼MPOD和OCT信息。使用Microsoft~?Excel,SPSS和R进行数据分析。结果:MPOD和中央黄斑厚度之间呈明显正相关(r=0.42,P<0.01)。同时,MPOD和BMI之间呈明显负相关(r=-0.23,P<0.01)。结论:研究得出,MPOD和中央黄斑厚度之间呈明显正相关。还需要进一步研究中央凹的详细结构及其与MPOD的关系。研究发现了MPOD与BMI之间呈明显正相关,且得出BMI的降低可能会增加黄斑色素的密度,这有助于预防年龄相关性黄斑变性(ARMD)。 | Lee Hong Nien Fazliana Ismail Rafidah Sudarno Angela Loo Voon Pei Visvaraja Subrayan | 2019 | 国际眼科杂志2019，19，5： | 3 |
| 2 | Inhibition effect of curcumin on UVB-induced secretion of pro-inflammatory cytokines from corneal limbus epithelial cells显示文摘AIM: To study the effects of curcumin on the secretion of interleukin(IL)-6 and IL-8 by corneal limbus epithelial cells. METHODS: Human corneal limbus epithelial cells were isolated and cultured from donor eyes and irradiated by UVB at different dosages with or without curcumin. MTT test was used for studying the effects of UVB and curcumin on the cell viability. The role of mitogen-activated protein kinase(MAPK) and nuclear factor-kappa B(NF-κB) pathways on the UVB-induced secretion of IL-6 and IL-8 were tested by addition of their inhibitors to the culture with or without UVB-radiation. Levels of various signal pathways, IL-6 and IL-8 in the cells and in the conditioned culture medium were measured by ELISA analysis. RESULTS: UVB at 20 mJ/cm^2 or less and curcumin at 20 μmol/L or less did not affect the cell viability of cultured limbus epithelial cells(P>0.05). UVB irradiation at 10 and 20 mJ/cm^2 induced a significant increase of secretion of IL-6 and IL-8 and upregulated NF-κB and phosphorylated MAPK pathways of cultured limbus epithelial cells(P<0.05). Various signal pathway inhibitors, including SP600125(JNK inhibitor), SB203580(p38 MAPK inhibitor) and BAY11-7082(NF-κB inhibitor) significantly decreased the UVB-induced secretion of IL-6 and IL-8 secretion(P<0.05). Curcumin at 5-20 μmol/L significantly inhibited UVBinduced secretion of IL-6 and IL-8 by limbus epithelial cells in a dose-dependent manner; while curcumin alone did not affect the secretion of IL-6 and IL-8. The upregulation of NF-κB and MAPK pathways induced by UVB treatment was significantly inhibited by curcumin, suggesting that NF-κB and MAPK pathways are involved in the inhibitory effect of curcumin on UVB-induced production of IL-6 and IL-8. CONCLUSION: Curcumin may be a promising agent to be explored for the prevention and treatment of pterygium. | Shih-Chun Chao Dan-Ning Hu Joan Roberts Xilun Shen Chia-Yi Lee Chan-Wei Nien Hung-Yu Lin | 2017 | International Journal of Ophthalmology(English edition)2017，10，6： | 2 |
| 3 | Chylous ascites in colorectal surgery:A systematic review显示文摘BACKGROUND Chylous ascites is a rare complication in colorectal surgery with limited evidence.AIM To systematically review all available evidence to describe the incidence,clinical presentation,risk factors and management strategies.METHODS The systematic review was performed through PubMed,MEDLINE,EMBASE and Cochrane and cross-checked up to November 2020.The data collated included:Demographics,indications(benign vs malignant),site of disease,surgical approach,extent of lymphadenectomy,day to and method of diagnosis of chylous ascites and management strategies.RESULTS A total of 28 studies were included in the final analysis(426 cases).Patient age ranged from 31 to 89 years.All except one case were performed for malignancy.Of the 426 cases,195 were right-colonic,121 left-colonic,103 pelvic surgeries and 7 others.The majority were diagnosed during the same inpatient stay by recognition of typical drain appearance and increased volume.Three cases were diagnosed during outpatient visits with increased abdominal distention and subsequently underwent paracentesis.Most cases were managed successfully non-operatively(fasting with prolonged drainage,total parenteral nutrition,somatostatin analogues or a combination of these).Only three cases required surgical intervention after failing conservative management and subsequently resolved completely.Risk factors identified include:Right-colonic surgery/tumour location,extent of lymphadenectomy and number of lymph nodes harvested.CONCLUSION Chylous ascites after colorectal surgery is a relatively rare complication.Whilst the majority of cases resolved without surgical intervention,preventative measures should be undertaken such as meticulous dissection and clipping of lymphatics during lymphadenectomy to prevent morbidity. | Zi Qin Ng Margaret Han Han Nien Beh Simon Keelan | 2021 | World Journal of Gastrointestinal Surgery2021，13，6： | 2 |
| 4 | A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate显示文摘 | Romero R Nien JK Espinoza J | 2008 | J Matern Fetal Neonatal Med2008，21，1： | 1 |
| 5 | Ellec- trically tunable liquid crysatl waveguide attenuator显示文摘 | Cai Dong-po Nien Shan-chi Chert Chii-chang | 2011 | Optics Express2011，19，11： | 1 |
| 6 | Antibiotic susceptibility pattern and erythromycin resistance mechanisms in beta- hemolytic group G Streptococcus dysgalaetiae subspecies equisimilis isolates from central Taiwan显示文摘 | Lo H H Nien H H Cheng Y Y | 2014 | J Microbiol Immunol Infect2014，，： | 1 |
| 7 | On the amperometric detection and electrocatalytic analysis of ascorbic acid and dopamine using a poly(acriflavine)-modified electrode显示文摘 | Nien PC Chen P Y Ho K C | 2009 | Sensors and ActuatorsB:Chemical2009，140，1： | 1 |
| 8 | The use of inversion mode and 3 D manual segmentation in volume measurement of fetal fluid-filled structures:comparison with virtual organ computer-aided anaLysis (VOCAL)显示文摘 | Kusanovic JP Nien JK Goncalves LF | | 0，，02： | 1 |
| 9 | A single-phase inverter system for PV power injection and active power filtering with nonlinear inductor consideration显示文摘 | WU T F NIEN H S SHEN C L | 2005 | IEEE Transactions on Industry Application2005，41，4： | 1 |
| 10 | Multi chaotic systems based pixel shuffle for image encryption显示文摘 | C.K. Huang H.H. Nien | 2009 | Optics Communications2009，，11： | 1 |
| 11 | Detection of uric acid based on multi-walled carbon nanotubes polymerized with a layer of molecularly imprinted PMAA 显示文摘 | CHEN P NIEN P HU C | 2010 | Sens Actuators B2010，146，： | 1 |
| 12 | Efficient approaches for materialized views selection in a data warehouse显示文摘 | Ming Chuan Hung Man Lin H uang Don Lin Yang Nien Lin H sueh | 2007 | Information Sciences2007，177，： | 1 |
| 13 | Multi chaotic systems based pixel shuffle for image encryption 显示文摘 | Huang C K Nien H H | 2009 | Optics Communications2009，282，21： | 1 |
| 14 | Preparation and characterization of electrospun polycaprolactone/ polyethylene oxide membranes 显示文摘 | Nien Y H Shih C Y Yang C Y | 2013 | J Polym Res2013，20，6： | 1 |
| 15 | Digital color image encoding and decoding using a novel chaotic random generator 显示文摘 | NIEN H H HUANG C K CHANGCHIEN S K | 2007 | Chaos Solitons and Fractals2007，32，3： | 1 |
| 16 | Diagnosis and treatment of rheumatoid arthritis显示文摘 | Misiūniene N Baranauskaite A | 2002 | Medicina (Kaunas)2002，38，1： | 1 |
| 17 | Human beta-defensin-2:a natural antimicrobial peptide present in amniotic fluid participates in the host response to microbial invasion of the amniotic cavity显示文摘 | Soto E Espinoza J Nien J K | | 0，，01： | 1 |
| 18 | Existence and multiplicity results for homoclinic orbits of Hamiltonian systems显示文摘 | Chao Nien Shyuh-yaur Tzeng | 1997 | Electronic Journal of Differential Equations1997，1997，7： | 1 |
| 19 | Resveratrol neuroprotective effects duringfocal cerebral ischemia injury via nitric oxide mecha-nism in rats显示文摘 | Tsai S K Hung L M Fu Y T Cheng H Nien M W LiuH Y | 2007 | J Vase Surg2007，46，： | 1 |
| 20 | PV power injection and active power filtering with amplitude-clamping and amplitude-scaling algorithms 显示文摘 | WU T F NIEN H S HSIEN H M SHEN C L | 2007 | IEEE Transactions on Industry Applications2007，43，3： | 1 |
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