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| 1 | Cost benefit analysis of the use of tranexamic acid in primary lower limb arthroplasty: A retrospective cohort study显示文摘AIM: To examine the cost benefit conferred by the perioperative administration of intravenous tranexamic acid(TXA) in lower limb arthroplasty.METHODS: This study evaluates the use of TXA in 200 consecutive lower limb arthroplasties performed in a single surgeon series. The initial 100 patients(control group) underwent surgery without perioperative administration of TXA while the subsequent 100 patients(TXA group) all received 1 g TXA at the time of induction of anaesthesia. Pre- and post-operative haemoglobin, platelet count, haematocrit, the use of blood product post-operatively, length of stay were examined. A financial analysis of both groups was then undertaken. RESULTS: The mean age of patients in both groups was 63 ± 13 years. There were no significant differences between groups in terms of gender(P = 0.47), proportion of total hip replacement to total knee replacement(P = 0.25) or pre-operative haemoglobin(P = 0.43). In the control group, the transfusion rate was 22%. In the TXA group, the transfusion rate dropped to 2%(P < 0.001). The mean post-operative haemoglobin was 10.82 ± 1.55g/dL in the control group vs 11.33 ± 1.27 g/dL in the TXA group(P = 0.01). The total cost of transfused blood products was €11055 and €603 respectively. The mean length of stay in the control group was 6.53 ± 5.93 d vs 5.47 ± 4.26 d in the TXA group(P = 0.15) leading to an estimated financial saving of €114586. There was one pulmonary embolus in the control group and one deep venous thrombosis in the TXA group.CONCLUSION: Intravenous TXA reduces blood loss in lower limb arthroplasty. This leads to lower transfusion rates, shorter length of stay in hospital and significant financial savings. | Niall P McGoldrick Eabhann M O'Connor Nikos Davarinos Rose Galvin John F Quinlan | 2015 | World Journal of Orthopedics2015，6，11： | 3 |
| 2 | Reasons of PEG failure to eliminate gastroesophageal reflux in mechanically ventilated patients显示文摘AIM:To investigate factors predicting failure of percutaneous endoscopic gastrostomy(PEG)to eliminate gastroesophageal reflux(GER). METHODS:Twenty-nine consecutive mechanically ventilated patients were investigated.Patients were evaluated for GER by pH-metry pre-PEG and on the 7th post-PEG day.Endoscopic and histologic evidence of reflux esophagitis was also carried out.A beneficial response to PEG was considered when pH-metry on the 7th post-PEG day showed that GER was below 4%. RESULTS:Seventeen patients responded(RESP group)and 12 did not respond(N-RESP)to PEG.The mean age,sex,weight and APACHEⅡscore were similar in both groups.GER(%)values were similar in both groups at baseline,but were significantly reduced in the RESP group compared with the N-RESP group on the 7th post-PEG day[2.5(0.6-3.8)vs 8.1(7.4-9.2, P<0.001)].Reflux esophagitis and the gastroesophageal flap valve(GEFV)grading differed significantly between the two groups(P=0.031 and P=0.020, respectively).Histology revealed no significant differences between the two groups.CONCLUSION:Endoscopic grading of GEFV and the presence of severe reflux esophagitis are predisposing factors for failure of PEG to reduce GER in mechanically ventilated patients. | Emmanuel E Douzinas Ilias Andrianakis Olga Livaditi Dimitrios Bakos Katerina Flevari Nikos Goutas Dimitrios Vlachodimitropoulos Marios-Konstantinos Tasoulis Alex P Betrosian | 2009 | World Journal of Gastroenterology2009，15，43： | 2 |
| 3 | DRAMMS:Deformable registration via attribute matching and mutual-saliency weighting 显示文摘 | Ou YM Aristeidis S Nikos P | 2011 | Medical Image Analysis2011，15，14： | 1 |
| 4 | Pulse pressure in normotensive:A marker of cardiovascular disease显示文摘 | Lekakis CM Nikos A John P | 2001 | Am J Hypertens2001，14，： | 1 |
| 5 | Evaluation of design alternatives for the 2-D-discrete wavelet transform 显示文摘 | Nikos D Z Giorgos P A | 2001 | IEEE Transactions on Circuits and Systems for Video Technology2001，11，12： | 1 |
| 6 | Autonomous vehicle navigation utilizing electrostatic potential fields and fuzzy logic显示文摘 | Tsourveloudis Nikos C Valavanis Kimon P Hebert Timothy | 2001 | IEEE Transactions on Robtics and Automation2001，17，4： | 1 |
| 7 | Active contours and level sets for the detection and tracking of moving objects显示文摘 | Nikos P Rachid D | 2000 | IEEE Transactions on Pattern Analysis and Machine Intelligence2000，22，3： | 1 |
| 8 | A framework for group decision support systems: Combining AI tools and OR techniques显示文摘 | Nikos K Costas P | 1997 | European Journal of Operational Research1997，103，： | 1 |
| 9 | Geodesic active contours and level sets for the detection and tracking of moving objects 显示文摘 | Nikos P Rachid D | 2000 | IEEE Transactions on Pattern Analysis and Machine Intelligence2000，22，3： | 1 |
| 10 | Mutlifunctional ATRP initiators:Synthesis of four-arm star homopolymers of methyl methacrylate and graft copolymers of polystyrene and poly(t-butyl methacrylate)显示文摘 | Polyxeni M Stergios P Nikos H | 2001 | J Polym Sci Part A:Polym Chem2001，39，： | 1 |
| 11 | Active contours and level sets for the detection and tracking of moving objects 显示文摘 | Nikos P Rachid D | 2000 | IEEE Transactions on Pattern Analysis and Machine Intelligence2000，22，3： | 1 |
| 12 | Transformation and normalvector calculation of parametrically defined surfacesbased on dual vectors and screw theory : Application toPhong's shading model 显示文摘 | Stavros G P Nikos A A | 2006 | Computer Graphics Forum2006，25，2： | 1 |
| 13 | Laparoscopically assisted myomec-tomy versus abdominal myomectomy in short-term outcomes:a prospec-tive study显示文摘 | Ioannis K Nikos P Panayotis X | 2013 | Archives of Gynecology and Obstetrics2013，12，5： | 1 |
| 14 | A stability algorithm for the dynamic analysis of inverter dominated unbalanced LV microgrids显示文摘 | NIKDS L S STAVROS A P NIKOS D H | 2007 | IEEE Trans on Power Systems2007，22，1： | 1 |
| 15 | Does endoscopic treatment for early oesophageal cancers give equivalent oncological outcomes as compared with oesophagectomy Best evidence topic(BET)显示文摘 | Athanasios F Omar J Nikos P | 2012 | International Journal of Surgery2012，10，9： | 1 |
| 16 | Geodesic active contours and level sets for the detection and tracking of moving objects显示文摘 | NIKOS P RACHID D | 2000 | IEEE Trans on Pattern Analysis and Machine Intelligence2000，22，3： | 1 |
| 17 | Random Forests as a Tool for Ecohydrological Distribution Modelling显示文摘 | Jan P Bernard D B Niko E C V Roeland S Sven D Piet D B Willy H | 2007 | Ecological Modelling2007，207，24： | 1 |
| 18 | Elastic-plastic response spectra for exponential blast loading显示文摘 | Charis J G Nikos G P | 2004 | International Journal of Impact Engineering2004，30，3： | 1 |
| 19 | Random Forests as a Tool for Ecohydrologieal Distribution Modelling显示文摘 | Jan P Bernard D B Niko E C | 2007 | Ecological Modelling2007，207，24： | 1 |
| 20 | Calculation and Stability Investigation of Periodic Steady States of the Voltage Converter Buck DC-DC Converter显示文摘 | GEORGIOS A P NIKOS I M | 2004 | IEEE Transactions on Power Electronics2004，19，7： | 1 |
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