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| 1 | Evaluation of degree of nerve root injury by dermatomal somatosensory evoked potential following lumbar spinal stenosis显示文摘BACKGROUND:Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) can display the site of lumbar spinal stenosis and predict nervous compression at the morphological level; however,pure morphological changes cannot reflect functional alterations in a compressed nerve root. Dermatomal somatosensory evoked potential (DSEP) provides a means to assess the functional state of a nerve root. OBJECTIVE: To evaluate the clinical significance of DSEP,assessing the degree of nerve root injury following lumbar spinal stenosis. DESIGN,TIME AND SETTING: A case-control study was performed in the Department of Orthopaedic Surgery,Hainan People’s Hospital,China,between September 2004 and December 2007. PARTICIPANTS: Forty-seven patients diagnosed with lumbar spinal stenosis by CT or MRI were selected as the case group; fifty healthy subjects were collected as the control group. METHODS: A KEYPOINT myoelectric evoked potential apparatus (DANTEC Company,Denmark) was used to measure DSEP,and stimulative spots were determined in accordance with the skin key sensory spot standards established by The American Spinal Injury Association: L4 in the medial malleolus,L5 in the third metatarsophalangeal joint of the dorsum of foot and S1 in the lateral heel. The needle electrode used as the recording electrode was located at the Cz point of the cranium,and the reference electrode at the Fz point. MAIN OUTCOME MEASURES: Latency of the P40 peak of DSEP,P1-N1 amplitude,P40 waveform and differentiation and disappearance of various waves. RESULTS: The sensitivity and diagnostic concurrence with surgery of nerve root injury following lumbar spinal stenosis evaluated by DSEP was 95.7 %. P40 latencies at L4,L5 and S1 in the case group were significantly longer than in the control group (P<0.05),and the P1-N1 amplitude in the case group was significantly lower than the control group (P<0.05-0.01). Nerve root injury was categorized according to DSEP latency as follows: severe damage (disappearance of the P40 wave in 103 dermatomes),moderate damage (prolongation of the P40 peak latency ≥ 3.0 times the standard deviation of the normal mean in 60 dermatomes) and mild damage (prolongation of the P40 peak latency ≥ 2.5 times the standard deviation of the normal mean in 31 dermatomes). CONCLUSION: DSEP can be used to determine the severity of nerve root injury following lumbar spinal stenosis with high sensitivity and specificity. | Ningjiang Shen Guangji Wang Jian Chen Xiaoli Wu Yutian Wang | 2008 | Neural Regeneration Research2008，3，11： | 2 |
| 2 | Reliability of dermatomal somatosensory-evoked potential in the evaluation of lumbosacral nerve root injury A concurrent case-control study显示文摘BACKGROUND: It has been reported that dermatomal somatosensory evoked potential (DSEP) can be used for diagnosing nerve root injury in patients with lumbar disc herniation (LDH), and that 83%-95% of patients suffer from the disease. Body height correction is not performed prior to determinations of latency and latency difference between the healthy and affected sides. However, latency noticeably correlates to body height. OBJECTIVE: This study aims to determine the lumbosacral nerve root injury in patients with LDH by DSEP, and to evaluate the sensitivity of the DSEP difference between the healthy and affected sides using a diagnostic index following body height correction. DESIGN: A case-control observation. SETTING: Department of Orthopedic Surgery, Hainan Provincial People's Hospital. PARTICIPANTS: Ninety-six patients, comprised of 67 males and 29 females, with an average age of 43 years and a mean body height of 1.65 m (range 1.48-1.81 m), were recruited for this study. These patients suffered from unilateral lower limb radiation pain and received treatment at the Department of Orthopedic Surgery, Hainan Provincial People's Hospital between January 2004 and December 2006. All patients were confirmed to suffer from LDH at the L3-4, L4-5, and/or L5-S1 by CT and/or MRI examinations. Central nervous system diseases were excluded. In order to obtain a normal reference value, DSEP was determined for a group of 50 subjects, who concurrently received health examinations in the same department. The subjects had no previous history of back leg pain or nervous system disease. The group of healthy controls included 26 males and 24 females, with an average age of 37 years and a mean body height of 1.63 m (range 1.50-1.80 m). Written informed consent was obtained from all subjects for laboratory samples. The protocol was approved by the Hospital's Ethics Committees. DSEP was determined with myoelectricity-evoked potential equipment (Keypoint, Batch No. 9020A0042591, Dantec Company, Denmark). METHODS: DSEP of patients with LDH was determined. Constant-voltage square pulse stimulation was used to determine DSEP, with the following parameters: a pulse wave width of 0.2 milliseconds; a saddle-like stimulating electrode; a stimulation intensity 3 times greater than the sensation threshold; a stimulation frequency of 1.5 Hz; mean superposition greater than 100 times; and inter-electrode impedance < 5 kΩ. The stimulation point was a skin key sensation point confirmed by the American Spinal Injury Association, i.e. L4 at medial malleolus, L5 at the third metatarsophalangeal joint on the dorsum of the foot, and S1 at the lateral heel. The recording electrode was a needle electrode, the recording point was Cz, and the reference electrode was Fz. DSEP latency of P40, and latency differences of P40, between the healthy side and the affected side, were determined. DSEP at L4, L5, and S1 nerve roots of the lower limbs of 50 healthy controls were bilaterally determined. The normal values of P40 latency and P40-N50 amplitude were statistically obtained. MAIN OUTCOME MEASURES: Determination of DSEP values. RESULTS: Ninety-six patients with LDH and fifty healthy controls participated in the final analysis. In the healthy controls, the amplitude of DSEP varied greatly, with a mean amplitude co-efficient of variation of 58% for L4, L5, and S1 dermatomes. P40 latency was stable, with a mean latency coefficient of variation of 4.7%. In patients with LDH, the P40 wave disappeared. P40 latency was 2.5 times prolonged compared to normal mean value. P40 latency difference between the healthy and the affected side was 2.5 times higher than the normal mean value of the healthy side. CONCLUSION: DSEP can reflect the functional status of lumbosacral nerve root. P40 latency difference between the healthy side and the affected side is the most sensitive diagnosis index for patients with LDH suffering from unilateral lower limb radiation pain. | Ningjiang Shen Jian Chen Guangji Wang Xiaoli Wu Yutian Wang | 2008 | Neural Regeneration Research2008，3，1： | 2 |
| 3 | Characteristics of water isotopes and hydrograph separation during the wet season in the Heishui River, China显示文摘 | Yuhong Liu Ningjiang Fan Shuqing An Xiaohua Bai Fude Liu Zhen Xu Zhongsheng Wang Shirong Liu | 2008 | Journal of Hydrology2008，，3： | 1 |
| 4 | Involvement of Na + /H + exchanger 1 in advanced glycation end products-induced proliferation of vascular smooth muscle cell显示文摘 | Shujin Wu Tao Song Shouhong Zhou Yuhui Liu Gengrong Chen Ningjiang Huang Liying Liu | 2008 | Biochemical and Biophysical Research Communications2008，，3： | 1 |
| 5 | Anti-intercellularadhesionmolecule-1antibodyreducesischemiccelldamageaftertransientbutbotpermanentmiddlecerebralarteryocclusioninthewistarrat显示文摘 | RuiLanZhang MichaelChopp NingJiang etal | 1995 | Stoke1995，26，： | 1 |
| 6 | Methylprednisolone and tetrandrine in combination with direct current electrical field for treating acute spinal cord injury显示文摘BACKGROUND: The direct current electrical field can effectively promote the regeneration of the spinal cord; moreover, methylprednisolone (MP) can relieve secondary edema after spinal cord injury. Tetrandrine (Tet) is an effective component of hanfangji and can protect the effect of spinal cord and axis-cylinder. Whether direct current electrical field combining with MP or Tet has synergic or strengthening effect on treating complete spinal cord injury or not should be studied further. OBJECTIVE:To study the effect of direct current electrical field assisted by MP and Tet on treating spinal cord injury. DESING: Randomized controlled animal study. SETTING: People's Hospital of Hainan Province. MATERIALS: A total of 45 healthy hybrid dogs, of both genders, weighing 10–12 kg, aged 1.5–2 years, were provided by Animal Center of Hainan Province. Somatosensory evoked potential meter (DANTEC Company), IBAS-2.0 imaging analysis meter (Germany), and self-made electronic stimulator. METHODS: The experiment was carried out in Hainan People's Hospital from May 2001 to June 2004. All experimental dogs were randomly divided into 4 groups: control group (n =9), electrostimulating group (n =12), MP + electrostimulating group (n =12) and Tet + electrostimulating group (n =12). ① After anesthesia, Allen WD method was used to induce complete spinal cord injury. The metal bar, which was 10 cm in height fell freely and vertically hit the spinal cord to provide a complete spinal cord injury. Dogs in control group and electrostimulating group were implanted electrical stimulators 6 hours after spinal cord injury (no electricity in control group); dogs in MP + electrostimulating group were injected 30 mg/kg MP for 15 minutes at 2 hours after spinal cord injury and electrical stimulators implanted at 6 hours after injury; dogs in Tet + electrostimulating group were intravenously injected with 7.5 mg/kg Tet at 2 hours after spinal cord injury and electrical stimulators implanted at 6 hours after injury; and then, 7.5 mg/kg Tet injected at days 2 and 3 after injury. ② Specimens were taken from control group from three dogs of every month; from the injured segments of spinal cords at 1 month, 2 months and 3 months; and from electrostimulating group, MP + electrostimulating group and Tet + electrostimulating group of 4 dogs for histological examinations. ③ Detection of neurological function: Neurological function was evaluated with the functional 10 grading system. The scores ranged from 0 to 10 (0: complete paraplegia; 10: normality). ④ Detection of cortical somatosensory evoked potential (CSEP): According to the scheme formulated by the International Electroencephalographical Association, the patterns of the fundamental waves were P1–N1– P1 waves. The latency of the P1 wave and the amplitude of P1–N1 waves were mainly observed individually at 1, 2 and 3 months after the injury. ⑤ Histological detection: All spinal cord specimens of the injuried segment were harvested at 1, 2 and 3 months after injury. They were stained with hematoxylin and Nissl staining methods, and then were observed under an optical microscope, and the neurons were counted. The sectional areas of the neurons and the density of the Nissl bodies were measured by a system image pattern analysis (IBAS-2.0, Germany). MAIN OUTCOME MEASURES: The neurological function, cortical somatosensory evoked potential, neuronal amount, sectional area of neurons and Nissl body density at 1 to 3 months after injury. RESULTS: All 45 experimental dogs were involved in the final analysis. ① Detection of neurological function: One month later, the dogs in MP + electrostimulating group could walk, but the dogs in electrostimulating group and Tet + electrostimulating group could stand. Two months after injury, the dogs in MP + electrostimulating group almost recovered to normal, but the dogs in electrostimulating group could walk and those in Tet + electrostimulating group could run. Those in control group had no parent recovery.② Detection of P1 latency and P1–N1 amplitude: Changes of P1 latency in control group were long and P1–N1 amplitude was very low at 1 month later. Compared to electrostimulating group, MP + electrostimulating group and Tet + electrostimulating group, there were significant differences (P < 0.05). P1 latency was manifestly shortened and amplitude were raised in electrostimulating group, MP + electrostimulating group and Tet + electrostimulating group. Those in MP + electrostimulating group and Tet + electrostimulating group were superior to those in electrostimulating group and there were significant differences (P < 0.05). ③ Sectional areas of neurons and Nissl body density: At 1–3 months after injury, sectional areas of neurons were larger in electrostimulating group [(170.14±7.45), (209.60± 14.80), (312.47±12.63) μm2], MP + electrostimulating group [(282.18±15.25), (418.18±16.27), (515.25± 15.10) μm2] and Tet + electrostimulating group [(231.81±7.38), (322.67±8.45), (386.82±10.42) μm2] than control group[(98.12±4.93), (113.50±6.74), (122.59±8.03) μm2, P < 0.05]; especially, sectional area was the largest in MP + electrostimulating group. At 1–3 months after injury, Nissl body density was more in electrostimulating group (170.14±7.45, 209.60±14.80, 312.47±12.63), MP + electrostimulating group (282.18±15.25, 418.18±16.27, 515.25±15.10) and Tet + electrostimulating group (231.81±7.38, 322.67±8.45, 386.82±10.42) than control group (98.12±4.93, 113.50±6.74, 122.59±8.03, P < 0.05); especially, Nissl body density was the most in MP + electrostimulating group. CONCLUSION: The direct current electrical field can effectively promote spinal cord regeneration. The combination of direct current electrical field with large dose MP or Tet has synergistic effects for treating spinal cord injury. The curative effects of direct current electrical field with large dose MP are much better than those with Tet. | Ningjiang Shen Yutian Wang Ji Cai | 2007 | Neural Regeneration Research2007，2，1： | 1 |
| 7 | NDRG2 in rat liver regeneration: Role in proliferation and apoptosis显示文摘 | JiandongYang YanLi LinWu ZhaoxiaZhang TenglongHan HangGuo NingJiang KaishanTao ZhenyuTi XinpingLiu LiboYao KefengDou | 2010 | Wound Repair and Regeneration2010，，5： | 1 |
| 8 | Using a direct current electrical field to promote spinal-card regeneration 显示文摘 | Shen Ningjiang Wang Shucheng | 1999 | Journal of Reconstructive Microsurgery1999，15，6： | 1 |
| 9 | Intelligent Multi-objective Anomaly Detection Method Based on Robust Sparse Flow显示文摘To meet the needs of transportation systems for smart scenic security services,real-time detection and identification of traffic anomalies with high accuracy is essential.Based on the multi-objective sparse optical flow estimation method based on KLT algorithm,an improved algorithm for robust sparse optical flow is designed.The Forward-Backward error calculation method was used to eliminate the error optical flow generated by the KLT algorithm and the robustness of optical flow was improved.The proposed algorithm was verified by the actual traffic scene monitoring example,and the anomaly detection accuracy is above 80%.Furthermore,it has good detection effect on the benchmark dataset. | Ke Wang Weishan Huang Yan Chen Ningjiang Chen Ziqi He | 2020 | 国际计算机前沿大会会议论文集2020，，2： | 0 |
| 10 | Adaptive Anomaly Detection Strategy Based on Reinforcement Learning显示文摘 | Youchang Xu Ningjiang Chen Hanlin Zhang Bimi Liang | 2018 | 国际计算机前沿大会会议论文集2018，，2： | 0 |
| 11 | Container Cluster Scheduling Strategy Based on Delay Decision Under Multidimensional Constraints显示文摘With the rise of online applications such as machine learning,stream processing,and interactive data-intensive applications in shared clusters,container cluster scheduling in data centers is facing new challenges.In order to solve the problem that application performance and economic cost cannot be balanced in a container cluster deploying a hybrid application,this paper proposes a container cluster scheduling strategy based on delay decision under multi-dimensional constraints.Formal language-based application placement constraints were introduced,and a task reorder model was established based on delayed decision-making.The experiments show that this strategy improves application performance and cluster utilization. | Yijun Xue Ningjiang Chen Yongsheng Xie | 2020 | 国际计算机前沿大会会议论文集2020，，1： | 0 |
| 12 | A Heterogeneous Cluster Multi-resource Fair Scheduling Algorithm Based on Machine Learning显示文摘 | Wenbin Liu Ningjiang Chen Hua Li Yusi Tang Bimi Liang | 2018 | 国际计算机前沿大会会议论文集2018，，1： | 0 |
| 13 | Workload-based randomization byzantine fault tolerance consensus protocol显示文摘This paper introduces a new Byzantine fault tolerance protocol called workload-based randomization Byzantine fault tolerance protocol(WRBFT).Improvements are made to the Practical Byzantine Fault Tolerance(PBFT),which has an important position in the Byzantine Fault consensus algorithm.Although PBFT has numerous ad-vantages,its primary node selection mechanism is overly fixed,the communication overhead of the consensus process is also high,and nodes cannot join and exit dynamically.To solve these problems,the WRBFT proposed in this paper combines node consensus workload and verifiable random function(VRF)to randomly select the more reliable primary node that dominates the consensus.The selection of the nodes involved in the consensus is based on the node workload,and the optimization of the agreement protocol of the PBFT is also based on this.Simulation results show that the WRBFT has higher throughput,lower consensus latency,and higher algorithmic efficiency compared to the PBFT. | Baohua Huang Li Peng Weihong Zhao Ningjiang Chen | 2022 | High-Confidence Computing2022，2，3： | 0 |
| 14 | A New Method for Synthesis of Methyl 3-Azido-3-deoxy-2-O-mesyl-5-O-benzoylxylofuranoside显示文摘A new method for synthesis of 3-azido-3-deoxyxylofuranoside was described. D-ribose was methylated, then treated with methanesulfonyl chloride to give II. II was selectively replaced by benzoate at the 5-position to give III. All these processes gave good yields. III was treated with sodium azide to afford IV, whose structure was determined by 1H NMR and 13C NMR. | ZiChengLI NingJIANG 等 | 2002 | Chinese Chemical Letters2002，13，3： | 0 |
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