|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | PPARγ activator,rosiglitazone:Is it beneficial or harmful to the cardiovascular system?显示文摘Rosiglitazone is a synthetic agonist of peroxisome proliferator-activated receptor γ which is used to improve insulin resistance in patients with typeⅡdiabetes.Rosiglitazone exerts its glucose-lowering effects by improving insulin sensitivity.Data from various studies in the past decade suggest that the therapeutic effects of rosiglitazone reach far beyond its use as an insulin sensitizer since it also has other benefits on the cardiovascular system such as improvement of contractile dysfunction,inhibition of the inflammatory response by reducing neutrophil and macrophage accumulation,and the protection of myocardial injury during ischemic/reperfusion in different animal models.Previous clinical studies in typeⅡdiabetes patients demonstrated that rosiglitazone played an important role in protectingagainst arteriosclerosis by normalizing the metabolic disorders and reducing chronic inflammation of the vascular system.Despite these benefits,inconsistent findings have been reported,and growing evidence has demonstrated adverse effects of rosiglitazone on the cardiovascular system,including increased risk of acute myocardial infarction,heart failure and chronic heart failure.As a result,rosiglitazone has been recently withdrawn from EU countries.Nevertheless,the effect of rosiglitazone on ischemic heart disease has not yet been firmly established.Future prospective clinical trials designed for the specific purpose of establishing the cardiovascular benefit or risk of rosiglitazone would be the best way to resolve the uncertainties regarding the safety of rosiglitazone in patients with heart disease. | Siripong Palee Siriporn Chattipakorn Arintaya Phrommintikul Nipon Chattipakorn | 2011 | World Journal of Cardiology2011，3，5： | 3 |
| 2 | Phosphodiesterase-3 inhibitor (cilostazol) attenuates oxidative stress-induced mitochondrial dysfunction in the heart显示文摘BackgroundCilostazol 是是的 3 phosphodiesterase 禁止者以前表明了阻止 tachyarrhythmia 的出现并且改进 defibrillation 功效的一种类型。然而,为这有益的效果的机制仍然是不清楚的。因为心脏的线粒体被显示了玩,在致命的心脏的心律不齐和那个氧化压力的一个关键角色是到心律不齐产生的主要贡献者之一,我们在严重氧化 stress.MethodsMitochondria 下面在心脏的线粒体上测试了 cilostazol 的效果从老鼠心被孤立并且与 H 对待 2导致氧化应力的 O 2。在各种各样的集中, Cilostazol 被用来学习它的保护的效果。药理学干预,包括一个 mitochondrial 渗透转变毛孔(mPTP ) blocker, cyclosporine A (CsA ) ,和一条内部膜阴离子隧道(IMAC ) blocker, 4 ′ -chlorodiazepam (CDP ) ,被用来在心脏的线粒体上调查 cilostazol 的机械学的角色。心脏的 mitochondrial 当当由阻止 mitochondrial 去极暴露了到氧化应力时,心脏的 mitochondrial function.ResultsCilostazol 的指示物保存了心脏的 mitochondrial 功能,反应的氧种类( ROS )生产,胀大的 mitochondrial 膜潜力变化和 mitochondrial 被决定, mitochondrial 胀大,并且减少 ROS production.ConclusionsOur 调查结果建议 cilostazol 的效果以前报导了的那 cardioprotective 能由于它的 | Siriporn C. Chattipakom Savitree Thummasorn Jantira Sanit Nipon Chattipakorn | 2014 | Journal of Geriatric Cardiology2014，11，2： | 3 |
| 3 | Gasdermin D-mediated pyroptosis in myocardial ischemia and reperfusion injury:Cumulative evidence for future cardioprotective strategies显示文摘Cardiomyocyte death is one of the major mechanisms contributing to the development of myocardial infarction(MI)and myocardial ischemia/reperfusion(MI/R)injury.Due to the limited regenerative ability of cardiomyocytes,understanding the mechanisms of cardiomyocyte death is necessary.Pyroptosis,one of the regulated programmed cell death pathways,has recently been shown to play important roles in MI and MI/R injury.Pyroptosis is activated by damage-associated molecular patterns(DAMPs)that are released from damaged myocardial cells and activate the formation of an apoptosisassociated speck-like protein containing a CARD(ASC)interacting with NACHT,LRR,and PYD domains-containing protein 3(NLRP3),resulting in caspase-1 cleavage which promotes the activation of Gasdermin D(GSDMD).This pathway is known as the canonical pathway.GSDMD has also been shown to be activated in a non-canonical pathway during MI and MI/R injury via caspase-4/5/11.Suppression of GSDMD has been shown to provide cardioprotection against MI and MI/R injury.Although the effects of MI or MI/R injury on pyroptosis have previously been discussed,knowledge concerning the roles of GSDMD in these settings remains limited.In this review,the evidence from in vitro,in vivo,and clinical studies focusing on cardiac GSDMD activation during MI and MI/R injury is comprehensively summarized and discussed.Implications from this review will help pave the way for a new therapeutic target in ischemic heart disease. | Panat Yanpiset Chayodom Maneechote Sirawit Sriwichaiin Natthaphat Siri-Angkul Siriporn C.Chattipakorn Nipon Chattipakorn | 2023 | Acta Pharmaceutica Sinica B2023，13，1： | 2 |
| 4 | Chalcone derivatives ameliorate lipopolysaccharide-induced acute lung injury and inflammation by targeting MD2显示文摘Acute lung injury(ALI)and its severe form acute respiratory distress syndrome(ARDS)are known as the common causes of respiratory failure in critically ill patients.Myeloid differentiation 2(MD2),a co-receptor of toll like receptor 4(TLR4),plays an important role in LPS-induced ALI in mice.Since MD2 inhibition by pharmacological inhibitors or gene knockout significantly attenuates ALI in animal models,MD2 has become an attractive target for the treatment of ALI.In this study we identified two chalcone-derived compounds,7w and 7x,as new MD2 inhibitors,and investigated the therapeutic effects of 7x and 7w in LPS-induced ALI mouse model.In molecular docking analysis we found that 7w and 7x,formed pi-pi stacking interactions with Phe^(151) residue of the MD2 protein.The direct binding was confirmed by surface plasmon resonance analysis(with KD value of 96.2 and 31.2μM,respectively)and by bis-ANS displacement assay.7w and 7x(2.5,10μM)also dose-dependently inhibited the interaction between lipopolysaccharide(LPS)and rhMD2 and LPS-MD2-TLR4 complex formation.In mouse peritoneal macrophages,7w and 7x(1.25−10μM)dose-dependently inhibited LPS-induced inflammatory responses,MAPKs(JNK,ERK and P38)phosphorylation as well as NF-κB activation.Finally,oral administration of 7w or 7x(10 mg·kg^(−1) per day,for 7 days prior LPS challenge)in ALI mouse model significantly alleviated LPS-induced lung injury,pulmonary edema,lung permeability,inflammatory cells infiltration,inflammatory cytokines expression and MD2/TLR4 complex formation.In summary,we identify 7w and 7x as new MD2 inhibitors to inhibit inflammatory response both in vitro and in vivo,proving the therapeutic potential of 7w and 7x for ALI and inflammatory diseases. | Ya-li Zhang Wen-xin Zhang Jue-qian Yan Ye-lin Tang Wen-jing Jia Zheng-wei Xu Ming-jiang Xu Nipon Chattipakorn Yi Wang Jian-peng Feng Zhi-guo Liu Guang Liang | 2022 | Acta Pharmacologica Sinica2022，43，1： | 2 |
| 5 | White blood cell segmentation and classifica-tion in microscopic bone marrow images显示文摘 | NIPON T U | 2005 | Lecture Notes in Computer Science2005，3614，： | 1 |
| 6 | Boundary Detection in Medical Images Using Edge Following Algorithm Based on Intensity Gradient and Texture Gradient Features显示文摘 | Krit Somkantha Nipon Theera-Umpon | 2011 | IEEE Transactions on Biomedical Engineering2011，58，3： | 1 |
| 7 | Effects of high-fat diet on insulin receptor function in rat hippocampus and the level of neuronal corticosterone显示文摘 | Wasana Pratchayasakul Sasiwan Kerdphoo Petnoi Petsophonsakul Anchalee Pongchaidecha Nipon Chattipakorn Siriporn C. Chattipakorn | 2011 | Life Sciences2011，，13： | 1 |
| 8 | Heart rate variability in myocardial infarction and heart failure显示文摘 | Nipon Chattipakorn Tanat Incharoen Natnicha Kanlop Siriporn Chattipakorn | 2007 | International Journal of Cardiology2007，，3： | 1 |
| 9 | White blood cell segmentation and classification in microscopic bone marrow images显示文摘 | Nipon TU | 2005 | Lecture Notes in Computer Science2005，3614，： | 1 |
| 10 | Heart rate variability in β-thalassemic mice显示文摘 | Tanat Incharoen Chontida Thephinlap Somdej Srichairatanakool Siriporn Chattipakorn Pranee Winichagoon Suthat Fucharoen Jim Vadolas Nipon Chattipakorn | 2006 | International Journal of Cardiology2006，，2： | 1 |
| 11 | non-homothetic granu lometric mixing theory with application to blood cell counting 显示文摘 | Nipon TU Dougherty E R Gader P D | 2001 | Pattern recognition2001，34，： | 1 |
| 12 | Automatic White Blood cell Classification Using Biased-output Neural Networks with Morphological Features显示文摘 | Nipon Theera-Umpon | 2003 | Thammasat Int J Sc Tech2003，8，1： | 1 |
| 13 | Early detection of cardiac involvement in thalassemia: From bench to bedside perspective显示文摘Myocardial siderosis is known as the major cause of death in thalassemia major(TM) patients since it can lead to iron overload cardiomyopathy.Although this condition can be prevented if timely effective intensive chelation is given to patients,the mortality rate of iron overload cardiomyopathy still remains high due to late detection of this condition.Various direct and indirect methods of iron assessment,including serum ferritin level,echocardiogram,non-transferrin-bound iron,cardiac magnetic resonance T2*,heart rate variability,and liver biopsy and myocardial biopsy,have been proposed for early detection of cardiac iron overload in TM patients.However,controversial evidence and limitations of their use in clinical practice exist.In this review article,all of these iron assessment methods that have been proposed or used to directly or indirectly determine the cardiac iron status in TM reported from both basic and clinical studies are comprehensively summarized and presented.Since there has been growing evidence in the past decades that cardiac magnetic resonance imaging as well as cardiac autonomic status known as the heart rate variability can provide early detection of cardiac involvement in TM patients,these two methods are also presented and discussed.The existing controversy regarding the assessment of cardiac involvement in thalassemia is also discussed. | Nut Koonrungsesomboon Siriporn C Chattipakorn Suthat Fucharoen Nipon Chattipakorn | 2013 | World Journal of Cardiology2013，5，8： | 1 |
| 14 | Characteristics and compressive properties of porous NiTi alloy synthesized by SHS technique 显示文摘 | Sirikul W Nipon D Lek S | 2009 | Materials Science and Engineering: A2009，515，12： | 1 |
| 15 | Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats显示文摘 | Hiranya Pintana Nattayaporn Apaijai Wasana Pratchayasakul Nipon Chattipakorn Siriporn C. Chattipakorn | 2012 | 2012 (11-1)2012，，11： | 1 |
| 16 | Technical Change and the Returns and Investments in Firm-level Training: Evidence from Thailand显示文摘 | Futoshi Yamauchi Nipon Poapongsakorn Nipa Srianant | 2009 | Journal of Development Studies2009，，10： | 1 |
| 17 | Modulating mitochondrial dynamics attenuates cardiac ischemia-reperfusion injury in prediabetic rats显示文摘Mitochondria are extraordinarily dynamic organelles that have a variety of morphologies,the status of which are controlled by the opposing processes of fission and fusion.Our recent study shows that inhibition of excessive mitochondrial fission by Drp1 inhibitor(Mdivi-1)leads to a reduction in infarct size and left ventricular(LV)dysfunction following cardiac ischemia-reperfusion(I/R)injury in high fat-fed induced pre-diabetic rats.In the present study,we investigated the cardioprotective effects of a mitochondrial fusion promoter(M1)and a combined treatment(M1 and Mdivi-1)in pre-diabetic rats.Wistar rats were given a high-fat diet for 12 weeks to induce prediabetes.The rats then subjected to 30 min-coronary occlusions followed by reperfusion for 120 min.These rats were intravenously administered M1(2 mg/kg)or M1(2 mg/kg)combined with Mdivi-1(1.2 mg/kg)prior to ischemia,during ischemia or at the onset of reperfusion.We showed that administration of M1 alone or in combination with Mdivi-1 prior to ischemia,during ischemia or at the onset of reperfusion all significantly attenuated cardiac mitochondrial ROS production,membrane depolarization,swelling and dynamic imbalance,leading to reduced arrhythmias and infarct size,resulting in improved LV function in pre-diabetic rats.In conclusion,the promotion of mitochondrial fusion at any time-points during cardiac I/R injury attenuated cardiac mitochondrial dysfunction and dynamic imbalance,leading to decreased infarct size and improved LV function in pre-diabetic rats. | Chayodom Maneechote Siripong Palee Sasiwan Kerdphoo Thidarat Jaiwongkam Siriporn C.Chattipakorn Nipon Chattipakorn | 2022 | Acta Pharmacologica Sinica2022，43，1： | 1 |
| 18 | Khabou,Detection and classification of MSTAR object via morphological shared-weight neural network显示文摘 | Nipon theera-Umpon Mohamed A | | 0，，： | 1 |
| 19 | Experiment on rearing of spotted babylon (Babylonia areolata Link 1807)显示文摘 | Nipon Siripan Luechai Darunchu | 2000 | Thai fisheries Gazette(Thailand)2000，53，6： | 1 |
| 20 | System-level training of neural networks for counting white blood cells显示文摘 | Nipon Theera-Umpon PaulD Gader | 2002 | IEEE Transactions on Systems MAN And Cybernetics2002，32，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员