3篇
您的检索式：作者名="Niu Wenmin"
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| 1 | Effects of combined acupuncture and eugenol on learning-memory ability and antioxidation system of hippocampus in Alzheimer disease rats via olfactory system stimulation显示文摘OBJECTIVE: To investigate the effects of combined acupuncture and eugenol on learning-memory ability and the antioxidation system of the hippocampus in Alzheimer disease (AD) rats. METHODS: Sixty Sprague Dawley rats, weighing (300±10) g, were randomly divided with 10 rats per group into a normal control group, AD model group, AD with cut olfactory nerve group, Xiu three-needle group, eugenol group, and combined acupuncture and eugenol group. The AD model was established by injection of amyloid β1-40 (Aβ 1-40). Morris maze tests were conducted for evaluating the learning-memory ability. Content of malo- ndialdehyde (MDA) and activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the hippocampus were detected. RESULTS: The average escape latency and the mean swimming distance in the normal control group, the Xiu three-needle group, the eugenol group, and the combined acupuncture and euge-nol group were significantly shorter than those in the AD model group (all P<0.01). The combined acupuncture and eugenol group had shorter escape latency and mean swimming distance than those in the Xiu three-needle group and the eugenol group. There were no significant differences between the Xiu three-needle group and the eugenol group and between the AD group and the AD with cut olfactory nerve group (P>0.05). Compared with the normal control group, the MDA content in the hippocampus significantly increased (P<0.05) and GSH-Px and SOD activities significantly decreased in the AD model group (P<0.01). Compared with the AD model group, significantly decreased (P< 0.01) and SOD and GSH-Px activities significantly increased in the Xiu three-needle group, eugenol group, and combined acupuncture and eugenol group (P<0.05). Compared with the Xiu three-needle group and eugenol group, the MDA content significantly decreased (P<0.05) and SOD and GSH-Px activities increased (P<0.05) in the combined acupuncture and eugenol group. There were no significant differences among the three indices between the Xiu three-needle group and the eugenol group and between the AD model group and the AD with cut olfactory nerve group (P>0.05). CONCLUSION: Both Xiu three-needle and eugenol can increase learning-memory ability, decrease MDA content, and increase SOD and GSH-Px activities in the hippocampus in AD rats. The combination of acupuncture with eugenol has stronger effects, and the effects depend on the olfactory pathway. | Zhibin Liu Wenmin Niu Xiaohang Yang Yuan Wang | 2013 | Journal of Traditional Chinese Medicine2013，33，3： | 10 |
| 2 | Effects of electronically stimulating Tianshu(ST 25) and Dachangshu(BL 25), Quchi(LI 11) and Shangjuxu(ST 37) on the expressions of jejunum c-kit protein and c-kit m RNA in rats with functional diarrhea显示文摘OBJECTIVE: To investigate the effects of electronically stimulating Tianshu(ST 25) and Dachangshu(BL 25), Quchi(LI 11) and Shangjuxu(ST 37) on the jejunum c-kit protein and c-kit m RNA in rats with functional diarrhea(FD).METHODS: FD models were established through intragastric administration with folium sennae. Experimental rats were then divided into 4 groups:blank group, model group, electroacupuncture group Ⅰ [Tianshu(ST 25) and Dachangshu(BL 25)of both sides] and electroacupuncture group Ⅱ [Quchi(Li 11) and Shangjuxu(ST 37) ofboth sides], 10 in each. After treatment with electroacupuncture for 10 days, The expressions of jejunum c-kit protein and c-kit m RNA in each group were detected with Western blot and Real-Time quantitative real-time polymerase chain reaction(PCR).RESULTS: The expressions of c-kit protein and c-kit m RNA in the model group increased significantly compared to those in the blank group(P < 0.01);the expressions in electroacupuncture group Ⅰsignificantly decreased compared to those in the model group(P < 0.01).CONCLUSION: Our findings suggest that electronically stimulating both Tianshu(ST 25) and Dachangshu(BL 25) significantly increased the expressions of jejunum c-kit protein and c-kit m RNA in FD rats, which means the treatment might have better therapeutic effects on FD. | Wang Yuan Niu Wenmin Yang Xiaohang Liu Na Liu Zhibin | 2016 | Journal of Traditional Chinese Medicine2016，36，6： | 3 |
| 3 | Influence of electroacupuncture on mitogen-activated protein kinase signal transduction in a rat model of cerebral ischemia/reperfusion显示文摘Following electroacupuncture at Baihui (DU 20) and Dazhui (DU 14) in a rat model of cerebral ischemia/reperfusion,extracellular-signal-regulated kinase expression in cerebral cortex and corpus striatum,serum glutathione reductase,glutathione peroxidase activity,and serum glutathione content were elevated,and neurobehavioral scores improved.However,these effects were antagonized by mitogen-activated protein kinase inhibitor PD98059.Results indicated that electroacupuncture reversed free radical chain reactions and oxidative stress injury caused by cerebral ischemia/reperfusion,thereby providing neuroprotection.This process could correlate with the mitogen-activated protein kinase signal transduction pathway. | Zhongren Li Meihong Shen Wenmin Niu Xiaoren Xiang | 2011 | Neural Regeneration Research2011，6，30： | 1 |
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