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| 1 | Transcriptional silencing of Dickkopf gene family by CpG island hypermethylation in human gastrointestinal cancer显示文摘AIM: To clarify alterations of Dickkopfs (Dkks) and Kremen2 (Krm2) in gastrointestinal cancer. METHODS: We investigated the expression profiles and epigenetic alterations of Dkks and Krm2 genes in gastrointestinal cancer using RT-PCR, tissue microarray analysis, and methylation specific PCR (MSP). Cancer cells were treated with the demethylating agent and/or histone deacetylase inhibitor. WST-8 assays and in vitro invasion assays after treatment with specific siRNA for those genes were performed. RESULTS: Dkks and Krm2 expression levels were reduced in a certain subset of the gastrointestinal cancer cell lines and cancer tissues. This was correlated with promoter hypermethylation. There were significant correlations between Dkks over-expression levels and beta-catenin over-expression in colorectal cancer. In colorectal cancers with beta-catenin over-expression, Dkk-1 expression levels were significantly lower in those with lymph node metastases than in those without. Down-regulation of Dkks expression by siRNA resulted in a significant increase in cancer cell growth and invasiveness in vitro.CONCLUSION: Down-regulation of the Dkks associated to promoter hypermethylation appears to be frequently involved in gastrointestinal tumorigenesis. | Tadateru Maehata Hiroaki Taniguchi Hiroyuki Yamamoto Katsuhiko Nosho Yasushi Adachi Nobuki Miyamoto Chie Miyamoto Noriyuki Akutsu Satoshi Yamaoka Fumio Itoh | 2008 | World Journal of Gastroenterology2008，14，17： | 19 |
| 2 | Long-term survival of a case with multiple liver metastases from duodenal gastrointestinal stromal tumor drastically reduced by the treatment with imatinib and hepatectomy显示文摘工具包受体酷氨酸激酶的组成的激活是在胃肠的基质肿瘤(大意) 的致病的一个关键因素。但是几乎没有 imatinib mesylate (IM ) 和外科疗法的联合是否能与 unresectable 在情况中延长幸存的很少信息多重肝转移。我们报导酷氨酸激酶禁止者 IM 和外科疗法对待的大意的手术后的复发的一个案例。对处理的起始的完全的反应(CR ) 为 18 瞬间继续,但是单个肝转移在 IM 处理期间在左肝的脑叶显示出生长。在再发性瘤的部分切除术以后,手术后的路线是平静的,没有复发,病人为 24 瞬间幸存。当前, imatinib 是为 non-resectable 大意的首要的治疗,但是单个代理人治疗经常导致肿瘤抵抗。就算到 imatinib 的忍耐发生, imatinib 和外科疗法的联合能在这里报导了的一些情况中延长幸存。然而,周期性的大意的很多案例上的进一步的研究是必要的评估治疗与外科相结合的 IM 的有效性。 | Chouhei Sakakura Akeo Hagiwara Koji Soga Koji Miyagawa Susumu Nakashima Tetsuji Yoshikawa Shuichi Kin Yuenn Nakase Nobuki Yamaoka Yoshihiko Sagara Hisakazu Yamagishi | 2006 | World Journal of Gastroenterology2006，12，17： | 5 |
| 3 | Quantitative analysis of apotosiss-related gene expression in heaptocellular carcionma 显示文摘 | Masahide IK Yasuaki H Nobuki K | 2002 | Cancer2002，95，9： | 1 |
| 4 | Synthesis of Mg-Al alloys by bulk mechanical alloying (BMA) and their hydrogen solubility显示文摘 | Nobuki Tohru Crivello Jean-Claude Kuji Toshiro | 2007 | Nippon Kinzoku Gakkaishi2007，71，8： | 1 |
| 5 | Clinical pharmacology and efficacy of levofloxacin in elderly patients显示文摘 | Nobuki Aoki Usuda Y koda Y | 1992 | Jap J Antibiot1992，45，5： | 1 |
| 6 | Clinical pharmacology and efficacy of levofloxaein in elderly patients显示文摘 | Nobuki A Toshimaru U Yutaka K | 1992 | Jap J Antibiot1992，45，5： | 1 |
| 7 | RASSF1 A and NORE1A methylation and BRAF- V600E mutations in thyroid tumors 显示文摘 | Nobuki Nakamura | 2005 | Laboratory Investigation2005，85，： | 1 |
| 8 | Deformation of Cast TiAI Intermetallic Compound at Elevated Temperatures 显示文摘 | Nobuki M Hashimoto K Takahashi J | 1990 | Mater TransJpn Inst Met1990，31，： | 1 |
| 9 | Influence of Alloy Composition on Hot Deformation Properties of Ti-AI Binary Intermetallics 显示文摘 | Nobuki M Tsujimoto T | 1991 | ISIJ International1991，31，8： | 1 |
| 10 | Factors associated with serum total homocysteine level in type 2 diabetes显示文摘 | Yumi Masuda Akira Kubo Akatsuki Kokaze Masao Yoshida Nobuki Fukuhara Yutaka Takashima | 2008 | Environmental Health and Preventive Medicine2008，，3： | 1 |
| 11 | Expression of Thyroid Transcription Factor-1 in Normal and Neoplastic Lung Tissues 显示文摘 | Nobuki Nakamura Eri Miyagi Shin-ichi Murata | 2002 | Modern Pathology2002，15，： | 1 |
| 12 | Clinical position of sitafloxacin in outpatient chemotherapy显示文摘 | Yoshihito N Nobuki A Kenji S el al | 2009 | Jpn J Antibiot2009，62，3： | 1 |
| 13 | Improvement of Mg-Al alloys for hydrogen storage applications显示文摘 | Crivello J C Nobuki T Kuji T | 2009 | Interna tional Journal of Hydrogen Energy2009，34，： | 1 |
| 14 | Development of Mg based hydrogen absorbing alloys prepared by mechanical alloy- ing显示文摘 | Nobuki T Kanekawa S Hatate M | 2013 | Journal of Alloys and Compounds2013，580，1： | 1 |
| 15 | :A simple method for the fabrication of low cost scanning near-field optical microscope probes with acrylic paint as coating element显示文摘 | Ruggero Micheletto Nobuki Yoshimatsu Satoshi Okazaki | 2001 | Optics Communications2001，188，： | 1 |
| 16 | The dissolution of titanium minerals in hydrochloric and sulfuric acids 显示文摘 | Masayuki Imahashi Nobuki Takamatsu | 1976 | Bull Chem Soc Jpn1976，49，6： | 1 |
| 17 | Deformation analysis of surface defect on plate rolling显示文摘 | Takashi I Nobuki Y Yoshlnori Y | 2003 | Tetsu-to-Hagane2003，89，11： | 1 |
| 18 | 显示文摘 | Oguni Nobuki | 1994 | Yuki Gosei Kagaku Kyokaishi1994，52，6： | 1 |
| 19 | A novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates inflammatory colonic injury in mice显示文摘 | Tohru Funakoshi Kenichiro Yamashita Nobuki Ichikawa Moto Fukai Tomomi Suzuki Ryoichi Goto Tetsu Oura Nozomi Kobayashi Takehiko Katsurada Shin Ichihara Michitaka Ozaki Kazuo Umezawa Satoru Todo | 2011 | Journal of Crohn’s and Colitis2011，，2： | 1 |
| 20 | Effect of vanadium on USY zeolite destruction in the presence of sodium ions and steam-studies by solid-state NMR显示文摘 | Kazuhiko H Takeshi E Nobuki U | 2003 | Applied catalysis A: General2003，249，： | 1 |
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