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您的检索式：作者名="Norbert Bauer"
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| 1 | Antidiabetic profiling of veramycins,polyketides accessible by biosynthesis,chemical synthesis and precursor-directed modification显示文摘Seven new polyketides,termed veramycins,were isolated from a Streptomyces sp.from the Sanofi microbial strain collection along with their known congeners NFAT-133 and TM-123.Veramycin A,anα-pyrone congener of TM-123 and NFAT-133 showed an increased baseline deoxy-glucose uptake in the absence of insulin in a modified L6 rat skeletal muscle cell line(L6 GLUT4 AS160-like cells).In addition,both compounds slightly increased the sensitivity to insulin in this cell line.Total syntheses of NFAT-133,TM-123 and veramycin A were accomplished starting from a central building block,which bears the three contiguous stereogenic centers of this polyketide family.Our approach enables an efficient,selective and flexible access to all possible isomers of the stereotriad for further exploration of this series as a potential anti-diabetic lead structure as exemplified by the synthesis of an NFAT-133 epimer.Finally,the corresponding biosynthetic gene cluster(BGC)was identified by genome sequencing and gene inactivation.Based on feeding experiments,a biosynthetic pathway was proposed,which enabled access to new veramycin A analogs by precursor-directed biosynthesis. | Denis Dardić Nils Böhringer Alberto Plaza Florian Zubeil Juliane Pohl Svenja Sommer Leo Padva Jonathan Becker Maria A.Patras Mona-Katharina Bill Michael Kurz Luigi Toti Sven W.Görgens Sören M.M.Schuler AndréBillion Oliver Schwengers Paulus Wohlfart Alexander Goesmann Norbert Tennagels Andreas Vilcinskas Peter E.Hammann Till F.Schäberle Armin Bauer | 2022 | Organic Chemistry Frontiers2022，9，6： | 1 |
| 2 | Impact of grade of dysplasia in villous adenomas of vater’s papilla显示文摘 | Claus-Dieter Heidecke M.D. Rosenberg Robert M. D. Markus Bauer M.D. Werner Martin M. D. Norbert Weigert M.D. Kurt Ulm M.D. Jürgen D. Roder M.D. Jórg-Rüdiger Siewert M.D | 2002 | World Journal of Surgery2002，，6： | 1 |
| 3 | 快速而又精确的测量——生产测量技术中的反射光检测方法显示文摘以光学反射原理为基础的反射光检测方法已成功地应用于汽车工业的车轮轮辋检测。三元催化器外壳检测和型材的直线度检测之中。集成在型材加工设备中的光学扫描仪,可以自动地完成三维数字数据的转换,从而可实现加工模具的变形自动校正。 | Norbert Bauer Dirk Berndt | 2004 | 现代制造2004，，10： | 0 |
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