|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Timely reperfusion for ST-segment elevation myocardial infarction:Effect of direct transfer to primary angioplasty on time delays and clinical outcomes显示文摘Primary percutaneous coronary intervention(PPCI) is the preferred reperfusion therapy for patients presenting with ST-segment elevation myocardial infarction(STEMI) when it can be performed expeditiously and by experienced operators. In spite of excellent clinical results this technique is associated with longer delays than thrombolysis and this fact may nullify the benefit of selecting this therapeutic option. Several strategies have been proposed to decrease the temporal delays to deliver PPCI. Among them,prehospital diagnosis and direct transfer to the cath lab,by-passing the emergency department of hospitals,has emerged as anattractive way of diminishing delays. The purpose of this review is to address the effect of direct transfer on time delays and clinical events of patients with STEMI treated by PPCI. | Rodrigo Estévez-Loureiro ángela López-Sainz Armo Pérez de Prado Carlos Cuellas Ramón Calvio Santos Norberto Alonso-Orcajo Jorge Salgado Fernández Jose Manuel Vázquez-Rodríguez Maria López-Benito Felipe Fernández-Vázquez | 2014 | World Journal of Cardiology2014，6，6： | 6 |
| 2 | CD4+ T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C virus-coinfected patients显示文摘AIM To characterize peripheral blood natural killer(NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus(HIV)/hepatitis C virus(HCV) coinfected patients.METHODS Peripheral mononuclear cells from 24 HIV/HCV(HBVnegative) coinfected and 5 HIV/HCV/HBV seronegative individuals were evaluated. HIV/HCV coinfected patients were divided in to groups: G1, patients with METAVIR F0-F2 and G2, patients with METAVIR F3-F4. NK surface cell staining was performed with: AntiCD3(APC/Cy7), anti-CD56(PE/Cy5), anti-CD57(APC), anti-CD25(PE), anti-CD69(FITC), anti-NKp30(PE), antiNKp46(PE/Cy7), anti-NKG2D(APC), anti-DNAM(FITC); anti-CD62L(PE/Cy7), anti-CCR7(PE), anti-TRAIL(PE), anti-Fas L(PE), anti CD94(FITC). Flow cytometry data acquisition was performed on BD FACSCanto, analyzed using Flow Jo software. Frequency of fluorescence was analyzed for all single markers. Clinical records were reviewed, and epidemiological and clinical data were obtained.RESULTS Samples from 11 patients were included in G1 and from 13 in G2. All patients were on ARV, with undetectable HIV viral load. Liver fibrosis was evaluated by transient elastography in 90% of the patients and with biopsy in 10% of the patients. Mean HCV viral load was(6.18 ± 0.7 log10). Even though, no major significant differences were observed between G1 and G2 regarding NK surface markers, it was found that patients with higher liver fibrosis presented statistically lower percentage of NK cells than individual with low to mild fibrosis and healthy controls(G2: 5.4% ± 2.3%, G1: 12.6% ± 8.2%, P = 0.002 and healthy controls 12.2% ± 2.7%, P = 0.008). It was also found that individuals with higher liver fibrosis presented lower CD4 LT count than those from G1(G2: 521 ± 312 cells/μL, G1: 770 ± 205 cells/μL; P = 0.035).CONCLUSION Higher levels of liver fibrosis were associated with lower percentage of NK cells and LTCD4+ count; and they may serve as noninvasive biomarkers of liver damage. | Natalia Laufer Diego Ojeda María Laura Polo Ana Martinez Héctor Pérez Gabriela Turk Pedro Cahn Norberto Walter Zwirner Jorge Quarleri | 2017 | World Journal of Hepatology2017，9，25： | 2 |
| 3 | New butenolides in plantlets of Virola surinamensis (Myristicaceae) 显示文摘 | NORBERTO P L PIERRE A D S MASSUO J K | 2004 | Chem Pharm Bull2004，52，10： | 1 |
| 4 | Antifungal constituents from roots of Virola surnamensis显示文摘 | NORBERTO P MASSUO J MASSAYOSHI Y | 1999 | Phytochemistry1999，51，1： | 1 |
| 5 | C-440T/T-331C polymorphisms in the UGT1A9 gene affect the pharmacokinetics of mycophenolic acid in kidney transplantation显示文摘 | Sara B Simona M Norberto P | | 0，，09： | 1 |
| 6 | Mycophenolate mofetil versus AZAthioprine for prevention of acute rejection in renal transplantation (MYSS): a randomised trial显示文摘 | Giuseppe R Mariadomenica L Eliana G Maria G Borislav DD Bogdan EI Giulia G Donato D Maurizio S Silvio S Umberto V Giuseppe S Georges M Stefano F Paolo R Vito S Jean-Louis B Norberto P Piero R | 2004 | Lancet2004，364，7： | 1 |
| 7 | Butanolides as a common feature of Iryanthera Lancifolia and Virola Surinamensis显示文摘 | Norberto P L Dulce H S S Massuo J K | 1998 | Phytochemiswy1998，49，5： | 1 |
| 8 | Plasma clearance of nonra- dioactive iohexol as a measure of glomerular filtration rate 显示文摘 | Flavio G Norberto P Piero R | 1995 | J Am Soc Nephrol1995，6，2： | 1 |
| 9 | The endemic Patagonian vespertilionid assemblage is a depauperate ecomorphological vicariant of species-rich neotropical assemblages显示文摘Vespertilionidae is the most diverse chiropteran family, and its diversity is concentrated in warmregions of the World; however, due to physiological and behavioral adaptations, these bats alsodominate bat faunas in temperate regions. Here we performed a comparative study of vespertili-onid assemblages from two broad regions of the New World, the cold and harsh Patagonia, versusthe remaining temperate-to-subtropical, extra-Patagonian eco-regions of the South AmericanSouthern Cone. We took an ecomorphological approach and analyzed the craniodental morpho-logical structure of these assemblages within a phylogenetic framework. We measured 17 cranio-dental linear variables from 447 specimens of 22 currently recognized vespertilionid species of thestudy regions. We performed a multivariate analysis to define the morphofunctional space, andcalculated the pattern and degree of species packing for each assemblage. We assessed the im-portance of phylogeny and biogeography, and their impact on depauperate (Patagonian) versusrich (extra-Patagonian) vespertilionid assemblages as determinants of morphospace structuring.We implemented a sensitivity analysis associated to small samples of rare species. The morpho-logical patterns were determined chiefly by the evolutionary history of the family. The Patagonianassemblage can be described as a structurally similar but comparatively depauperate ecomorpho-logical version of those assemblages from neighboring extra-Patagonian eco-regions. ThePatagonian assemblage seems to have formed by successively adding populations from Northernregions that eventually speciated in the region, leaving corresponding sisters (vicariants) in extra-Patagonian eco-regions that continued to be characteristically richer. Despite being structurallyakin, degree of species packing in Patagonia was comparatively very low, which may reflect the ef-fect of limited dispersal success into a harsh region for bat survival. | Analia L. GIMENEZ Norberto P, GIANNINI | 2017 | Current Zoology2017，63，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员