|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Agritourism:motivations behind farm/rarch business diversification,journal of travel research显示文摘 | NORMA POLOVITZ NICKERSON RITA J BLACK STEPHEN F MCCOOL | 2001 | Norma Polovitz Nickerson2001，，1： | 1 |
| 2 | Analysis of reactive oxygen species generating systems in rat epididymal spermatozoa显示文摘 | Patrick V Norma F Ceanna W | 2006 | Biol Reprod2006，65，： | 1 |
| 3 | Time course of hexachlorobenzene - induced alterations of lipid metabolima and their relation to Forphyria显示文摘 | SILVIA B D C NORMA S S MARIA C F | 1997 | Int J Biochern Cell Biol1997，，29： | 1 |
| 4 | Antimicrobial susceptibility pattern and plasmid profile in Salmonella Muenster isolated from wine and abattoir environment, Brazil显示文摘 | Norma S L Anita T Eliane M F | 2004 | Pesquisa Veteri- naria Brasileira2004，24，2： | 1 |
| 5 | Turning on the microscope turret: a new view for the study of brassinosteroid signaling in plant development显示文摘 | Norma Fàbregas Ana I. Ca?o‐Delgado | 2014 | Physiol Plantarum2014，，2： | 1 |
| 6 | Metabolic profiles of sunflower genotypes with contrasting response to Sclerotinia sclerotiorum infection显示文摘 | Peluffo L Lia V Troglia C Maringolo C Norma P Escande A Esteban Hopp H Lytovchenko A Fernie A R Heinz R Carrari F | 2010 | Phytochemistry2010，71，1： | 1 |
| 7 | Immunomodulatory oligonucleotide IMT504:Effects on mesenchymal stem cells as a first-in-class immunoprotective/immunoregenerative therapy显示文摘The immune responses of humans and animals to insults(i.e., infections, traumas, tumoral transformation and radiation) are based on an intricate network of cells and chemical messengers. Abnormally high inflammation immediately after insult or abnormally prolonged proinflammatory stimuli bringing about chronic inflammation can lead to life-threatening or severely debilitating diseases. Mesenchymal stem cell(MSC) transplant has proved to be an effective therapy in preclinical studies which evaluated a vast diversity of inflammatory conditions. MSCs lead to resolution of inflammation, preparation for regeneration and actual regeneration, and then ultimate return to normal baseline or homeostasis. However, in clinical trials of transplanted MSCs, the expectations of great medical benefit have not yet been fulfilled. As a practical alternative to MSC transplant, a synthetic drug with the capacity to boost endogenous MSC expansion and/or activation may also be effective. Regarding this, IMT504, the prototype of a major class of immunomodulatory oligonucleotides, induces in vivo expansion of MSCs, resulting in a marked improvement in preclinical models of neuropathic pain, osteoporosis, diabetes and sepsis. IMT504 is easily manufactured and has an excellent preclinical safety record. In the small number of patients studied thus far, IMT504 has been well-tolerated, even at very high dosage. Further clinical investigation is necessary to demonstrate the utility of IMT504 for resolution of inflammation and regeneration in a broad array of human diseases that would likely benefit from an immunoprotective/immunoregenerative therapy. | Jorge Zorzopulos Steven M Opal Andrés Hernando-Insúa Juan M Rodriguez Fernanda Elías Juan Fló Ricardo A López Norma A Chasseing Victoria A Lux-Lantos Maria F Coronel Raul Franco Alejandro D Montaner David L Horn | 2017 | World Journal of Stem Cells2017，9，3： | 1 |
| 8 | Melatonin prevents oxidative stress,inflammatory activity,and DNA damage in cirrhotic rats显示文摘BACKGROUND Cirrhosis is an important health problem characterized by a significant change in liver parenchyma.In animals,this can be reproduced by an experimental model of bile duct ligation(BDL).Melatonin(MLT)is a physiological hormone synthesized from serotonin that has been studied for its beneficial properties,including its antioxidant potential.AIM To evaluate MLT’s effects on oxidative stress,the inflammatory process,and DNA damage in an experimental model of secondary biliary cirrhosis.METHODS Male Wistar rats were divided into 4 groups:Control(CO),CO+MLT,BDL,and BDL+MLT.MLT was administered(20 mg/kg)daily beginning on day 15 after biliary obstruction.On day 29 the animals were killed.Blood samples,liver tissue,and bone marrow were collected for further analysis.RESULTS BDL caused changes in biochemical and histological parameters and markers of inflammatory process.Thiobarbituric acid(0.46±0.01)reactive substance levels,superoxide dismutase activity(2.30±0.07)and nitric oxide levels(2.48±0.36)were significantly lower(P<0.001)n the groups that received MLT.DNA damage was also lower(P<0.001)in MLT-treated groups(171.6±32.9)than the BDL-only group(295.5±34.8).Tissue damage and the expression of nuclear factor kappa B,interleukin-1β,Nrf2,NQO1 and Hsp70 were significantly lower in animals treated with MLT(P<0.001).CONCLUSION When administered to rats with BDL-induced secondary biliary cirrhosis,MLT effectively restored the evaluated parameters. | Josieli R Colares Renata M Hartmann Elizângela G Schemitt Sandielly R B Fonseca Marilda S Brasil Jaqueline N Picada Alexandre S Dias Aline F Bueno Cláudio A Marroni Norma P Marroni | 2022 | World Journal of Gastroenterology2022，28，3： | 1 |
| 9 | Efficient formal total synthesis of physostigmine and physovenine : Conformational analysis of key intermediates 显示文摘 | MARTHA S NORMA F PEDRO J | 2002 | J Nat Prod2002，65，： | 1 |
| 10 | Finite-time thermoeconomic optimization of a solar-driven heat engine model 显示文摘 | Marco A B Norma S F A | 2011 | Entropy2011，13，1： | 1 |
| 11 | Rice kernel moisture content variation at harvest显示文摘 | Kocher M F Siebenmorgen T J Norma R J | 1990 | Transactions of the ASAE1990，33，2： | 1 |
| 12 | First imported Plasmodium ovale malaria in Central America: Case report of a Guatemalan soldier and a call to improve its accurate diagnosis显示文摘The Mesoamerican Ministers of Health have set 2020 as the target for malaria elimination to be achieved in the region. Imported malaria cases are a potential threat to countries attempting elimination or working to prevent resurgence. We report the first imported Plasmodium ovale infection with molecular confirmation in Central America, which occurred in a Guatemalan soldier that had been deployed in Africa. The obstacles for its diagnosis using the standard microscopy technique and the need to improve its detection are discussed. | María Eugenia Castellanos Sheilee Díaz Emily Parsons Leonard F Peruski Fabiola Enríquez Juan Luis Ramírez Norma Padilla | 2014 | Journal of Medical Colleges of PLA(China)2014，29，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员