|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Aberrant gene methylation in the peritoneal fluid is a risk factor predicting peritoneal recurrence in gastric cancer显示文摘AIM:To investigate whether gene methylation in the peritoneal fluid (PF) predicts peritoneal recurrence in gastric cancer patients.METHODS: The gene methylation of CHFR (checkpoint with forkhead and ring finger domains), p16, RUNX3 (runt-related transcription factor 3), E-cadherin, hMLH1 (mutL homolog 1), ABCG2 (ATP-binding cassette, sub-family G, member 2) and BNIP3 (BCL2/adenovirus E1B 19 kDa interacting protein 3) were analyzed in 80 specimens of PF by quantitative methylation-specific polymerase chain reaction (PCR). Eighty patients were divided into 3 groups; Group A (n=35):the depth of cancer invasion was less than the muscularis propria; Group B (n=31): the depth of cancer invasion was beyond the muscularis propria. Both group A and B were diagnosed as no cancer cells in peritoneal cytology and histology; Group C (n=14): disseminated nodule was histologically diagnosed or cancer cells were cytologically defi ned in the peritoneal cavity.RESULTS: The positive rates of methylation in CHFR, E-cadherin and BNIP3 were significantly different among the 3 groups and increased in order of group A, B and C (0%,0% and 21% in CHFR, P<0.05; 20%, 45% and 50% in E-cadherin, P<0.05;26%,35% and 71% in BNIP3, P<0.05). In addition, the multigene methylation rate among CHFR, E-cadherin and BNIP3 was correlated with group A, B and C (9%,19% and 57%, P<0.001). Moreover, the prognosis was analyzed in group B, excluding 3 patients who underwent a non-curative resection. Two of the 5 patients with multigene methylation showed peritoneal recurrence after surgery, while those without or with a single gene methylation did not experience recurrence (P<0.05).CONCLUSION: This study suggested that gene methylation in the PF could detect occult neoplastic cells in the peritoneum and might be a risk factor for peritoneal metastasis. | Masatsugu Hiraki Yoshihiko Kitajima Seiji Sato Jun Nakamura Kazuyoshi Hashiguchi Hirokazu Noshiro Kohji Miyazaki | 2010 | World Journal of Gastroenterology2010，16，3： | 20 |
| 2 | Metastatic basaloid-squamous cell carcinoma of the esophagus treated by 5-fluorouracil and cisplatin显示文摘Basaloid squamous cell carcinoma (BSC) of the esophagus is a rare malignant disease. We report here a patient with recurrent esophageal BSC,who was successfully treated by systemic chemotherapy containing 5-fluorouracil (5-FU) and cisplatin (CDDP). A 57-year-old woman was diagnosed as having squamous cell carcinoma of the esophagus upon endoscopic examination. Curative esophagectomy with lymph node dissection was performed under the thoracoscope. The pathological diagnosis of the surgical specimen was BSC. Five months after operation,the patient was diagnosed as having a recurrence of the BSC with metastases to the liver and spleen,and a right paraclavicular lymph node. She was given systemic chemotherapy consisting of continuous infusion of 800 mg/d of 5-FU and 3 h infusion of 20 mg/d of CDDP for 5 consecutive days every 4 wk. The metastatic lesions in the spleen and right paraclavicular lymph node disappeared,and the liver metastasis was apparently reduced in size after 2 courses of chemotherapy. The tumor regression was seen over 6 courses,with progression afterwards. Although subsequent treatment with CPT-11 and CDDP was not effective,docetaxel and vinorelbine temporarily controlled the tumor growth for 2 mo. 5-FU and CDDP combination may be useful for the patients with advanced BSC. | Yoshihiro Shibata Eishi Baba Hiroshi Ariyama Ryusuke Miki Nobumichi Ogami Shuji Arita Baoli Qin Hitoshi Kusaba Kenji Mitsugi Hirokazu Noshiro Takashi Yao Shuji Nakano | 2007 | World Journal of Gastroenterology2007，13，26： | 9 |
| 3 | Methylation-mediated gene silencing as biomarkers of gastric cancer:a review显示文摘Despite a decline in the overall incidence of gastric cancer(GC),the disease remains the second most common cause of cancer-related death worldwide and is thus a significant global health problem.The best means of improving the survival of GC patients is to screen for and treat early lesions.However,GC is often diagnosed at an advanced stage and is associated with a poor prognosis.Current diagnostic and therapeutic strategies have not been successful in decreasing the global burden of the disease;therefore,the identification of reliable biomarkers for an early diagnosis,predictive markers of recurrence and survival and markers of drug sensitivity and/or resistance is urgently needed.The initiation and progression of GC depends not only on genetic alterations but also epigenetic changes,such as DNA methylation and histone modification.Aberrant DNA methylation is the most well-defined epigenetic change in human cancers and is associated with inappropriate gene silencing.Therefore,an increasing number of genes methylated at the promoter region have been targeted as possible biomarkers for different purposes,including early detection,classification,the assessment of the tumor prognosis,the development of therapeutic strategies and patient follow-up.This review article summarizes the current understanding and recent evidence regarding DNA methylation markers in GC with a focus on the clinical potential of these markers. | Jun Nakamura Tomokazu Tanaka Yoshihiko Kitajima Hirokazu Noshiro Kohji Miyazaki | 2014 | World Journal of Gastroenterology2014，20，34： | 7 |
| 4 | Granulomatous reaction in hepatic inflammatory angiomyolipoma after chemoembolization and spontaneous rupture显示文摘A 77-year-old Japanese woman was transported to a nearby hospital due to sudden abdominal pain and transient loss of consciousness. Abdominal computed tomography(CT) suggested hemoperitoneum and hepatic nodule. She was conservatively treated. Contrast-enhanced CT two months later revealed an increased mass size, and the enhancement pattern suggested the possibility of hepatocellular carcinoma(HCC). Under a clinical diagnosis of HCC, transcatheter arterial chemoembolization(TACE) was performed. A subsequent imaging study revealed that most of the lipiodol used for the embolization was washed out. Therefore, surgical resection was performed. Histologically, the nodule contained numerous inflammatory cells including small lymphocytes, plasma cells and macrophages. Notably, epithelioid granulomatous features with multinucleated giant cells were observed in both the nodule and background liver. Some of the multinucleated giant cells contained oil lipid. Among the infiltrating inflammatory cells,spindle-shaped, histiocytoid or myoid tumor cells with eosinophilic cytoplasm were found. The tumor cells were positive for Melan A and HMB45. The nodule contained many Ig G4-positive plasma cells; these were counted and found to number 72.6 cells/HPF(range: 61-80). The calculated Ig G4:Ig G ratio was 33.2%. The nodule was finally diagnosed as previously ruptured inflammatory angiomyolipoma modified by granulomatous reaction after TACE. | Keita Kai Atsushi Miyosh Shinichi Aishima Kota Wakiyama Shunya Nakashita Shinji Iwane Shinya Azama Hiroyuki Irie Hirokazu Noshiro | 2015 | World Journal of Gastroenterology2015，21，32： | 4 |
| 5 | Formalin fixation on HER-2 and PD-L1 expression in gastric cancer:A pilot analysis using the same surgical specimens with different fixation times显示文摘BACKGROUND The needs for human epidermal growth factor receptor 2(HER-2) and/or programmed death-ligand 1(PD-L1) evaluations in gastric cancer are dramatically increasing. Although the importance of standardization of sample fixation has been widely recognized, most of the evidence regarding the fixation duration or type of fixing solution are based on breast cancer.AIM To investigate the real effects of fixation conditions on HER-2 testing or PD-L1 testing for gastric cancer using gastrectomy specimens.METHODS Thirty-two patients who underwent gastrectomy for gastric cancer were enrolled.Their resected specimens were each divided into four pieces and fixed in four strictly controlled different durations(6 h, 24 h, and 48 h, and 1 wk) by 10%formalin(n = 22) or 10% neutral buffered formalin(NBF)(n = 10).Immunohistochemistry(IHC) of HER-2 and PD-1 was performed, and a pathology examination was conducted. In the HER-2-immunoreactive cases, all four specimens were subjected to dual-color in situ hybridization(DISH). Five cases were assessed as HER-2-positive by IHC and DISH. We used the cut-off values of 1%, 10%, and 50% to assess the IHC findings of PD-L1.RESULTS No significant difference was observed in comparisons between the shorter fixation period groups(6 h, 24 h, and 48 h) and the prolonged fixation period(1 wk) group in the HER-2 and PD-L1 analyses. Although no significant difference was observed between 10% formalin and 10% NBF within 1 wk of fixation, the superiority of 10% NBF was confirmed in a long-term(> 3 mo) fixation in both the HER-2 and PD-L1 analyses.CONCLUSION In this small-numbered pilot study, prolonged fixation within 1 wk showed no inferiority in HER-2 or PD-L1 testing. However, a large-numbered prospective study is needed to obtain conclusive results. | Keita Kai Yukie Yoda Atsushi Kawaguchi Akimichi Minesaki Hironori Iwasaki Shinichi Aishima Hirokazu Noshiro | 2019 | World Journal of Clinical Cases2019，7，4： | 4 |
| 6 | Basic helix-loop-helix transcription factors DEC1 and DEC2 regulatethe paclitaxel-induced apoptotic pathway of MCF-7 human breast cancer cells显示文摘 | Yunyan Wu Fuyuki Sato Ujjal Bhawal Takeshi Kawamoto Katsumi Fujimoto Mitsuhide Noshiro Satoko Morohashi Yukio Kato Hiroshi Kijima | 2011 | International Journal of Molecular Medicine2011，，4： | 3 |
| 7 | Occult hepatitis B virus infection and surgical outcomes in non-B, non-C patients with curative resection for hepatocellular carcinoma显示文摘AIM To investigate the prevalence, clinicopathological characteristics and surgical outcomes of occult hepatitis B virus(HBV) infection(OBI) in patients with non-B, non-C(NBNC) hepatocellular carcinoma(HCC).METHODS This study retrospectively examined the cases of 78 NBNC patients with curative resection for HCC for whom DNA could be extracted from formalin-fixed paraffin-embedded tissue. OBI was determined by the HBV-DNA amplification of at least two different sets of primers by TaqM an realtime polymerase chain reaction. Possibly carcinogenetic factors such as alcohol abuse, diabetes mellitus, obesity and non-alcoholic steatohepatitis(NASH) were examined. Surgical outcomes were evaluated according to diseasefree survival(DFS), overall survival(OS) and diseasespecific survival(DSS).RESULTS OBI was found in 27/78 patients(34.6%) with NBNC HCC. The OBI patients were significantly younger than the non-OBI cases at the time of surgery(average age 63.0 vs 68.1, P = 0.0334) and the OBI cases overlapped with other etiologies significantly more frequently compared to the non-OBI cases(P = 0.0057). OBI had no impact on the DFS, OS or DSS. Only tumorrelated factors affected these surgical outcomes.CONCLUSION Our findings indicate that OBI had no impact on surgical outcomes. The surgical outcomes of NBNC HCC depend on early tumor detection; this reconfirms the importance of a periodic medical examination for individuals who have NBNC HCC risk factors. | Hiroki Koga Keita Kai Shinichi Aishima Atsushi Kawaguchi Koutaro Yamaji Takao Ide Junji Ueda Hirokazu Noshiro | 2017 | World Journal of Hepatology2017，9，35： | 2 |
| 8 | Prediction of postoperative complications in elderly patients with hepatocellular carcinoma显示文摘 | Takao Ide Atsushi Miyoshi Kenji Kitahara Hirokazu Noshiro | 2013 | Journal of Surgical Research2013，，： | 2 |
| 9 | Lymphadenectomy along the left recurrent laryngeal nerve by a minimally invasive esophagectomy in the prone position for thoracic esophageal cancer显示文摘 | Hirokazu Noshiro Hironori Iwasaki Kiitiro Kobayashi Akihiko Uchiyama Yoshihiro Miyasaka Toshihiro Masatsugu Kenta Koike Kouji Miyazaki | 2010 | Surgical Endoscopy2010，，： | 2 |
| 10 | Laparoscopically assisted distal gastrectomy with standard radical lymph node dissection for gastric cancer显示文摘 | H. Noshiro E. Nagai S. Shimizu A. Uchiyama M. Tanaka | 2005 | Surgical Endoscopy2005，，12： | 2 |
| 11 | Friction proper- ties of WS2/MoS2 multilayer films under vacuum environ- ment显示文摘 | WATANABE S NOSHIRO J MIYAKE S | 2004 | Surface & Coatings Technology2004，188，11： | 1 |
| 12 | Laparoscopic gastric surgery in a Japanese institution:analysis of the initial 100 procedures显示文摘 | Shimizu S Noshiro H Nagai E | 2003 | J Am Coll Surg2003，197，3： | 1 |
| 13 | Friction properties of WS2/ MoS2 multilayer films under vacuum environment 显示文摘 | Watanabe S Noshiro J Miyake S | 2004 | Surface & Coatings Technology2004，18，8189： | 1 |
| 14 | High vesicular cholesterol and protein in bile are associated with formation of cholesterol but not pigment gallstones显示文摘 | Dr. Kazuo Chijiiwa MD Ichio Hirota MD Hirokazu Noshiro MD | 1993 | Digestive Diseases and Sciences1993，，1： | 1 |
| 15 | Laparoscopy-assisted distal gastrectomy for early gastric cancer, is it beneficial for patients of heavier weight?显示文摘 | Noshiro H Shimizu S Nagai E | 2003 | Ann Surg2003，238，5： | 1 |
| 16 | Laparoscopic gastric surgery in a Japanese institution:analysis of the initial 100 procedures显示文摘 | Shimizu S Noshiro H Nagai E | 2003 | J Am Coll Surg2003，197，3： | 1 |
| 17 | Twenty-six-years' survival with multiple bone metastasis of malignant pheochromocytoma 显示文摘 | Yoshida S Hatori M Noshiro T | 2001 | Arch Orthop Trauma Surg2001，121，10： | 1 |
| 18 | Friction properties of WS2/MoS2 multilayer films under vacuum environment显示文摘 | WATANABE S NOSHIRO J MIYAKE S | 2004 | Surface & Coatings Technology2004，，： | 1 |
| 19 | Role of surgery for gallbladder carcinoma with special reference to lymph node metastasis and stage using western and Japanese classification systems 显示文摘 | Chijiiwa K Noshiro H Nakano K | 2000 | World J Surg2000，24，10： | 1 |
| 20 | Morphometric analysis of regional lymph nodes with and without metastasis from early gastric carcinoma 显示文摘 | Nakamura K Morisaki T Noshiro H | 2000 | Cancer2000，88，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员