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352篇 您的检索式:作者名="Nowak C"
    题名 作者 年代 出处 被引量
1Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174T human colon carcinoma cells显示文摘AIM:To investigate the impact of arachidonic acid (AA) and docosahexaenoic acid (DHA) and their combination on colon cancer cell growth.METHODS:The LS-174T colon cancer cell line was used to study the role of the prostaglandin precursor AA and the omega-3 polyunsaturated fatty acid DHA on cell growth. Cell viability was assessed in XTT assays. For analysis of cell cycle and cell death,flow cytometry and DAPI staining were applied. Expression of cyclooxygenase-2 (COX-2),p21 and bcl-2 in cells incubated with AA or DHA was examined by real-time RT-PCR. Prostaglandin E2 (PGE2) generation in the presence of AA and DHA was measured using a PGE2-ELISA.RESULTS:AA increased cell growth,whereas DHAreduced viability of LS 174T cells in a time-and dose-dependent manner. Furthermore,DHA down-regulated mRNA of bcl-2 and up-regulated p21. Interestingly,DHA was able to suppress AA-induced cell proliferation and significantly lowered AA-derived PGE2 formation. DHA also down-regulated COX-2 expression. In addition to the effect on PGE2 formation,DHA directly reduced PGE2-induced cell proliferation in a dose-dependent manner. CONCLUSION:These results suggest that DHA can inhibit the pro-proliferative effect of abundant AA or PGE2.Piet Habbel Karsten H Weylandt Katja Lichopoj Johannes Nowak Martin Purschke Jing-Dong Wang Cheng-Wei He Daniel C Baumgart Jing X Kang 2009World Journal of Gastroenterology2009,15,9:2
2Population Dynamics of Immune Responses to Persistent Viruses 显示文摘NOWAK M A BANGHAM C R M 1996Science1996,272,5258:1
3Hydraulic lift among native plant species in the Mojave Desert显示文摘YODER C K NOWAK R S 1999Plant and soil1999,215,1:1
4Assessment of plama enhanced machining for improved machinability of Inconel718显示文摘Nowak JW Shin Y C Incropera F P 1997Journal of Manufacturing Science and Engineering1997,119,:1
5Pickup and Delivery with Split Loads 显示文摘Nowak M Ergun O White C C 2008Transportation Science (S1526-5447)2008,42,1:1
62006, Air pollution removal by urban trees and shrubs in the United States 显示文摘NOWAK D J CRANE D E STEVENS J C 2006Urban Forestry and Urban Greening2006,4,34:1
7Mid-regionpro-hormonemarkersfordiagnosis and prognosis in acute dyspnea:results from the BACH (Biomarkers in Acute Heart Failure) trial显示文摘Maisel A Mueller C Nowak R 2010JAm Coll Cardiol2010,55,19:1
8Highly variable gastric emptying in patients with insulin dependent diabetes mellitus显示文摘Nowak T V Johnson C P Kalbfleisch J H 1995Gut1995,37,1:1
9Air pollution removal by urban trees and shrubs in the United States 显示文摘Nowak D J Crane D E Stevens J C 2006Urban Forestry and Urban Greening2006,4,:1
10Examples of energy self-sufficient municipal nutrient removal plants 显示文摘NOWAK O KEIL S FIMML C 2011Water Science and Technology2011,64,1:1
11Air pollution removal by urban trees ashrubs in the United States显示文摘NOWAK D J CRAN~ D E STENENS J C 2006Urban For Urban Green2006,4,34:1
12T-Cell Induced Pathogenesis in HIV: Bystander Effects and Latent Infection 显示文摘KRAKAUER D C NOWAK M A 1999Proc Biol Sci1999,266,1423:1
13Evaluation of HfN thin films considered as diffusion barriers in the Al/HfN/Si system显示文摘Nowak R Li C L 1997Thin Solid Films1997,305,1:1
14显示文摘Shang C H Nowak J Jansen R 1998Phys Rev B1998,58,6:1
15Muscle disease caused by mutation in the skeletal muscle alpha-actlon gene (ACTA1) 显示文摘Sparrow J C Nowak K J Durling H J 2003Neuromuscu Disord2003,13,78:1
16Performance of multiple cardiac biomarkers measured in the emergency department in patients with chronic kidney and chest pain显示文摘McCullough PA Nowak RM Foreback C 2002Acad Emerg Med2002,12,12:1
17Performance of multiple cardiac biomarkers measured in the emergency department in patients with chronic kidney disease and chest pain显示文摘McCullough PA Nowak RM Foreback C 2002Acad Emerg Med2002,9,12:1
18Emergence of cooperation and evolutionary stability in finite populations显示文摘Nowak M A Sasaki A Taylor C 2004Nature2004,428,:1
19Plasma concentrations ofthe vasoactive peptide fragments mid-regional pro-adrenomedullin,C-terminal pro-endothelin 1 and copeptin in hemodialysis patients :associated factors and prediction of mortality 显示文摘Artunc F Nowak A Mueller C 2014PLoS One2014,9,86:1
20Effects of urban tree management and species selection on atmospheric carbon dioxide显示文摘 Stevens J C Sisinni S M 2002Journal of Arboriculture2002,28,3:1
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