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| 1 | Kidney GATA3^(+) regulatory T cells play roles in the convalescence stage after antibody-mediated renal injury显示文摘FoxP3^(+)regulatory T cells(Tregs)play crucial roles in peripheral immune tolerance.In addition,Tregs that reside or accumulate in nonlymphoid tissues,called tissue Tregs,exhibit tissue-specific functions and contribute to the maintenance of tissue homeostasis and repair.In an experimental mouse model of crescentic glomerulonephritis induced by an anti-glomerular basement membrane antibody,Tregs started to accumulate in the kidney on day 10 of disease onset and remained at high levels(~30–35%of CD4^(+)T cells)during the late stage(days 21–90),which correlated with stable disease control.Treg depletion on day 21 resulted in the relapse of renal dysfunction and an increase in Th1 cells,suggesting that Tregs are essential for disease control during the convalescence stage.The Tregs that accumulated in the kidney showed tissue Treg phenotypes,including high expression of GATA3,ST2(the IL33 receptor subunit),amphiregulin(Areg),and PPARγ.Although T-bet^(+) Tregs and RORγt^(+) Tregs were observed in the kidney,GATA3^(+) Tregs were predominant during the convalescence stage,and a PPARγagonist enhanced the accumulation of GATA3^(+) Tregs in the kidney.To understand the function of specific genes in kidney Tregs,we developed a novel T cell transfer system to T cell-deficient mice.This experiment demonstrates that ST2,Areg,and CCR4 in Tregs play important roles in the accumulation of GATA3^(+) Tregs in the kidney and in the amelioration of renal injury.Our data suggest that GATA3 is important for the recruitment of Tregs into the kidney,which is necessary for convalescence after renal tissue destruction. | Ryota Sakai Minako Ito Kyoko Komai Mana Iizuka-Koga Kazuhiko Matsuo Takashi Nakayama Osamu Yoshie Koichi Amano Hiroshi Nishimasu Osamu Nureki Masato Kubo Akihiko Yoshimura | 2021 | Cellular & Molecular Immunology2021，18，5： | 2 |
| 2 | Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains显示文摘 | OGISO H ISHITANI R NUREKI O | 2002 | Cell2002，110，6： | 1 |
| 3 | CC chemokine receptor 4 ligand production by bronchoalveolar lavage fluid cells in cigarette-smoke-associated acute eosinophilic pneumonia显示文摘 | NUREKI S MIYAZAKI E ANDO M | | 0，，01： | 1 |
| 4 | Hard metal lurg disease successfully treated with inhaled corticosteroids 显示文摘 | Nureki S Miyazaki E Nishio S | 2013 | Intern Med2013，52，17： | 1 |
| 5 | Incidentally discoveredprimary malignant melanoma of the trachea 显示文摘 | Nureki S Miyazaki E Fujisaki H | 2012 | Intern Med2012，51，13： | 1 |
| 6 | Exophiala dermatitidis pneumonia successfully treated with long-term itraconazole therapy显示文摘 | Mukai Y Nureki S Hata M | 2014 | J Infect Chemother2014，20，7： | 1 |
| 7 | Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains显示文摘 | Ogiso H Ishitani R Nureki O | 2002 | Cell2002，110，： | 1 |
| 8 | Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion显示文摘 | KOBAYASHI T NUREKI O ISHITANI R | 2003 | Nature Structural Biology2003，10，6： | 1 |
| 9 | Structural basis for RNA unwinding by the DEAD-box protein Drosophila Vasa显示文摘 | Sengoku T Nureki O Nakamura A | | 0，，02： | 1 |
| 10 | Crystallization and preliminary X - ray diffraction analysis of the extracellular domain of the cell Surface antigen CD38 complexed with ganglioside 显示文摘 | KUKIMOTO M NUREKI O SHIROUZU M et at | 2000 | J Biochem2000，127，： | 1 |
| 11 | Elevated soluble ADAM8 in bronchoalveolar lavage fluid in patients with eosinophilie pneumonia显示文摘 | Matsuno O Miyazaki E Nureki S | 2007 | Int Arch Allergy Immunol2007，142，4： | 1 |
| 12 | Elevated levels ofthymus-and activation-regulated chemokine in bronchoalveo-lar lavage fluid from patients with eosinophilic pneumonia显示文摘 | Miyazaki E Nureki S Fukami T | 2002 | Am J Respir Crit Care Med2002，165，8： | 1 |
| 13 | Crystal structure of the complex of human epidermal gnwtth factor and receptor extracellular domaine显示文摘 | Ogiso H Ishitani R Nureki O | 2002 | Cell2002，110，6： | 1 |
| 14 | Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains显示文摘 | Ogiso H Ishitani R Nureki O | 2002 | Cell2002，110，6： | 1 |
| 15 | Structural basis of novel interactions between the small-GTPase and GDI-like domains in prokaryotic FeoB iron transporter显示文摘 | Hattori M Jin Y Nishimasu H Tanaka Y Mochizuki M Uchiumi T Ishitani R Ito K Nureki O | 2009 | Structure2009，17，10： | 1 |
| 16 | Hard metal lung disease successfully treated with inhaled corticosteroids 显示文摘 | Nureki S Miyazaki E Nishio S | 2013 | Intern Med2013，52，17： | 1 |
| 17 | Pyrrolysine analogs as substrates for bacterial pyrrolysyl-tRNA synthetase in vitro and in vivo 显示文摘 | Katayama H Nozawa K Nureki O | 2012 | Biosci Biotechnol Biochem2012，76，1： | 1 |
| 18 | Editing mechanism of aminoaeyl-tRNA synthetases operates by a hybrid ribozyme/ protein catalyst显示文摘 | Hagiwara Y Field M J Nureki O | 2010 | J Am Cbem Soc2010，132，8： | 1 |
| 19 | Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains 显示文摘 | Ogiso H Ishitani R Nureki O | 2002 | Cell2002，110，6： | 1 |
| 20 | Hard metal lung disease successfully treated with inhaled corticosteroids显示文摘 | Nureki S Miyazaki E Nishio S | 2013 | Intern Med2013，52，17： | 1 |
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