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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Uncoupling protein-3 mRNA levels are increased in white adipose tissue and skeletal muscle of bezafibrate-treated rats显示文摘 | AGATHA C GEMMA L NURIA R | 1999 | Bichem Biophys Ras Commun1999，260，50： | 1 |
| 3 | Bufalin influences the repair of X-ray-induced DNA breaks in Chinese hamster cells显示文摘 | NURIA P FELIPE C | 2003 | DNA Repair2003，2，12： | 1 |
| 4 | Chilling and heat requirements of sweet cherry cultivars and the relationship between altitude and the probability of satisfying the chill require- rnents显示文摘 | NURIA A FEDERICO G M ANTONIO C LORENZO B | 2008 | Environmental and Exoerimental Botany2008，，1： | 1 |
| 5 | Epigenomic plasticity enables human pancreatic [alpha] to [Beta] cell reprogramming显示文摘 | Bramswig Nuria C Everett Logan J Schug Jonathan Dorrell Craig Liu Chengyang Luo Yanping Streeter Philip R Naji Ali Grompe Markus Kaestner Klaus H | 2013 | Journal of Clinical Investigation2013，，3： | 1 |
| 6 | Microstructure Affects the Rate of Chemical,Physical and Color Changes during Storage of Dried Apple Discs显示文摘 | Nuria C Acevedo Vilbett Briones Pilar Buera | | 0，，85： | 1 |
| 7 | A GIS-based multivariate statistical analysis for shallow landslide susceptibility mapping in La Pob lade Lillet area(Eastern Pyrenees, Spain)显示文摘 | Nuria S B Baeza B Jordi C | 2003 | Natural Hazards2003，30，： | 1 |
| 8 | IBQS: A synthetic index of soil quality based on soil macro-invertebrate communi- ties显示文摘 | Nuria R Jerome M Leonide C | 2011 | Soil Biology and Biochemistry2011，43，10： | 1 |
| 9 | IBQS:A synthetic index of soil quality based on soil macro-invertebrate communities显示文摘 | Nuria R Jér?me M Léonide C Christine R Gérard H Etienne I Patrick L | | 0，，： | 1 |
| 10 | Expression and molecular a-nalysis of the Arabidopsis DXR gene encoding 1-deoxy-d-xylulose 5-phosphate reductoisomerase,the first committed enzyme of the 2-C-methyl-D-erythritol 4-phosphate pathway显示文摘 | Lorenzo C P Iván A Nuria C | 2002 | Plant Physiol2002，129，： | 1 |
| 11 | Advances in machine vision applications for automatic inspection and quality evalu- tion of fruits and vegetables 显示文摘 | SERGIO C NURIA A ENRIQUE M | 2011 | Food Bioprocess Technol2011，，4： | 1 |
| 12 | Pollutant emissions during pyrolysis and combustion of waste printed circuit boards, before and after metal removal 显示文摘 | NURIA O JUAN A C JULIA M | 2014 | Science of the Total Environment2014，499，： | 1 |
| 13 | Uncoupling protein-3 mRNA levels are increased in white adipose tissue and skeletal muscle of bezafibrate-treated rats显示文摘 | Agatha C Gemma L Nuria R | 1999 | Bichem Biophys Ras Commun1999，260，50： | 1 |
| 14 | Relation between oxidative stress markers and antioxidant endogenous defences during exhaustive exercise显示文摘 | Antoni Sureda Pedro Tauler Antoni Aguiló Nuria Cases Emilia Fuentespina Alfredo Có rdova Josep A. Tur Antoni Pons | 2005 | Free Radical Research2005，，： | 1 |
| 15 | Lung cancer risk of nonsmokers and GSTM1 and GSTT1 genetic polymorphism 显示文摘 | Nuria M Anne-Marie C B Fredrik N | 2000 | Can Epid Bio &Pre2000，9，： | 1 |
| 16 | IBQS: A synthetic index of soil quality based on soil macro-invertebrate communities 显示文摘 | Nuria R J6r6me M L6onide C | 2011 | Soil Biology and Biochemistry2011，43，10： | 1 |
| 17 | Temporal dynamics of arbuscular mycorrhizal fungi colonizing roots of representative shrub species in a semi-arid Mediterranean eeosystem显示文摘 | SANCHEZ-CASTRO I NURIA F PABLO C | 2012 | Mycorrhiza2012，22，6： | 1 |
| 18 | Chilling and heat requirements of sweet cherry cultivars and the relationship between altitude and the probability of satisfying the chill requirements 显示文摘 | NURIA A FEDERICO G M ANTONIO C | 2008 | Environmental and Experimental Botany2008，，1： | 1 |
| 19 | Ozenoxacin 1% cream in the treatment of impetigo: a multicenter, randomized, placebo- and retapamulin- controlled clinical trial显示文摘 | Savion G Nuria A Klaus C | 2014 | Future Microbiol2014，9，9： | 1 |
| 20 | Cardiovascular risk factors and frontotemporal dementia: a case–control study显示文摘Cardiovascular risk factors(CRF)were widely described as related to dementia.There are very few studies regarding this association in FTD.The objective of the study was to compare the frequency of CRF in our population with FTD and controls.100 consecutive subjects with FTD diagnosis according to Lund-Manchester clinical criteria and 200 controls matched by age and sex were included between January 2003 to February 2007 at the Cognitive and Behavior Unit of Hospital Italiano de Buenos Aires.Clinical evaluation,laboratory tests,brain images(CT/MRI),neuropsychological and neuropsychiatric assessment were performed.Multiple regression analysis was performed to analyze the association in CRF between FTD patients vs.controls.The mean age in FTD was 69.7±0.9 vs.70.1±0.8 in controls(p 0.12).No difference in gender was observed between cases and controls.No differences were identified between patients and controls regarding hypertension(HTA)(65%vs.67,3%p 0.44);dyslipidemia(57%vs.54.7%p 0.74);obesity(39%vs.27.6%p 0.14)and hypothyroidism(26%vs.17.1%p 0.1).A significant difference was observed for Diabetes Mellitus(39%vs.22.6%p 0.001).In our population,Diabetes Mellitus was associated as an independent risk factor for FTD.To our knowledge this is the first report in which CRF were evaluated prospectively in FTD patients.More studies are needed to confirm this finding in larger populations. | Angel Golimstok Nuria Cámpora Juan I Rojas María C Fernandez Cristina Elizondo Enrique Soriano Edgardo Cristiano | 2014 | Translational Neurodegeneration2014，3，1： | 1 |
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