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	题名	作者	年代	出处	被引量
1	Molecular Mechanisms Contributing to Resistance to Tyrosine Kinase-Targeted Therapy for Non-Small Cell Lung Cancer显示文摘One of the most important pathways in non-small cell lung cancer(NSCLC) is the epidermal growth factor receptor(EGFR) pathway. This pathway affects several crucial processes in tumor development and progression,including tumor cell proliferation,apoptosis regulation,angiogenesis,and metastatic invasion.Targeting EGFR is currently being intensely explored.We are witnessing the development of a number of potential molecular-inhibiting treatments for application in clinical oncology.In the last decade,the tyrosine kinase(TK) domain of the EGFR was identified in NSCLC patients,and it has responded very well with a dramatic clinical improvement to TK inhibitors such are gefitinib and erlotinib.Unfortunately,there were primary and/or secondary resistance to these treatments,as shown by clinical trials.Subsequent molecular biology studies provided some explanations for the drug resistance phenomenon.The molecular mechanisms of resistance need to be clarified.An in-depth understanding of these targeted-therapy resistance may help us explore new strategies for overcoming or reversing the resistance to these inhibitors for the future of NSCLC treatment.	Fariz Nurwidya Akiko Murakami Fumiyuki Takahashi Kazuhisa Takahashi	2012	Clinical oncology and cancer resexreh2012，9，1：	6
2	The Role of Innate and Adaptive Immune Cells in the Immunopathogenesis of Chronic Obstructive Pulmonary Disease显示文摘	Nurwidya F Damayanti T Yunus F	2016	Tuberc Respir Dis(Seoul)2016，79，1：	1
3	Epithelial mesen- chymal transition in drug resistance and metastasis of lung cancer 显示文摘	Nurwidya F Takahashi F Murakami A	2012	Cancer Res Treat2012，44，3：	1
4	From tumor hypoxia to cancer progression: the implications of hypoxia- inducible factor-1 expression in cancers 显示文摘	Nurwidya F Takahashi F Minakata K	2012	Anat Cell Bi- ol2012，45，2：	1
5	Epithelial mesenchymal transition in drug resistance and metastasis of lung cancer显示文摘	Nurwidya F Takahashi F Murakami A	2012	Cancer Res Treat2012，44，3：	1
6	Epithelial mesen- chymal transition in drug resistance and metastasis of lung cancer 显示文摘	Nurwidya F Takahashi F Murakami A	2012	Cancer Res Treat2012，44，3：	1
7	Lung cancer stem cells:Tumor biology and clinical implications显示文摘	Nurwidya F Murakami A Takahashi F		Asia Pac J ( ''lin ()ncol 21)120，8，3：	1
8	From tumor hypoxia to cancer progression: the implications of hypoxia-inducible factor expression in cancers显示文摘	Nurwidya F Takahashi F Minakata K	2012	Anat Cell Biol2012，45，2：	1
9	Cancer epithelial mesenchymal transition in drug resistance and metastasis of lung 显示文摘	Nurwidya F Takahashi F Murakami A	2012	Cancer Res Treat2012，44，：	1
10	Epithelial mesenchymal transition in drug resistance and metastasis of lung cancer显示文摘	Nurwidya F Takahashi F Murakami A	2012	Cancer Res Treat2012，44，3：	1
11	The Role of Innate and Adaptive Immune Ceils in the Immunopathogenesis of Chronic Obstructive Pulmonary Disease显示文摘	NURWIDYA F DAMAYANTI T YUNUS F	2016	Tuberc Respir Dis (Seoul)2016，9，1：	1
12	Acquired resistance of non-small cell lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors 显示文摘	Nurwidya F Takahashi F Murakami A	2014	Respir Investig2014，52，2：	1
13	Lung cancer stem cells:Tumor biology and clinical implications显示文摘	Nurwidya F Murakami A Takahashi F		0，，03：	1
14	Hypoxia induces gefitinib resistance in non‐small‐cell lung cancer with both mutant and wild‐type epidermal growth factor receptors显示文摘	Kunihiko Minakata Fumiyuki Takahashi Takeshi Nara Muneaki Hashimoto Ken Tajima Akiko Murakami Fariz Nurwidya Suzu Yae Fumiaki Koizumi Hiroyuki Moriyama Kuniaki Seyama Kazuto Nishio Kazuhisa Takahashi	2012	Cancer Sci2012，，11：	1
15	Epithelial mesen- chymal transition in drug resistance and metastasis of lung cancer显示文摘	Nurwidya F Takahashi F Murakami A	2012	Cancer Res Treat2012，44，3：	1
16	From tumor hypoxia to cancer progression: the implications of hypoxia-inducible fac- tor-1 expression in cancers 显示文摘	Nurwidya F Takahashi F Minakata K	2012	Anatomy & Cell Biology2012，45，2：	1
17	Epithelial mesenchymal transition in drug resistance and metastasis of lung cancer显示文摘	Nurwidya F Takahashi F Murakami A	2012	Cancer Res Treat2012，44，3：	1
18	Hypoxia increases gefitinib-resistant lung cancer stem ceils through the activation of insulin-like growth factor 1 receptor显示文摘	Murakami A Takahashi F Nurwidya F	2014	PLoS One2014，9，86：	1
19	The role of innate and adaptive immune cells in the immunopathogenesis of chronic obstructive pulmonary disease显示文摘	Nurwidya F Damayanti T Yunus F	2016	Tuberc Respir Dis (Seoul)2016，79，1：	1
20	From tumor hypoxia to cancer progression:the implications of hypoxia-inducible fac-tor-1 expression in cancers显示文摘	Nurwidya F Takahashi F Minakata K		0，，02：	1

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