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	题名	作者	年代	出处	被引量
1	Urinary metabolic insights into host-gut microbial interactions in healthy and IBD children显示文摘AIMTo identify metabolic signatures in urine samples from healthy and inflammatory bowel disease(IBD)children.METHODSWe applied liquid chromatography and gas chromatography coupled to targeted mass spectrometry(MS)-based metabolite profiling to identify and quantify bile acids and host-gut microbial metabolites in urine samples collected from 21 pediatric IBD patients monitored three times over one year(baseline,6 and 12 mo),and 27age-and gender-matched healthy children.RESULTSurinary metabolic profiles of IBD children differ significantly from healthy controls.Such metabolic differences encompass central energy metabolism,amino acids,bile acids and gut microbial metabolites.In particular,levels of pyroglutamic acid,glutamic acid,glycine and cysteine,were significantly higher in IBD children in the course of the study.This suggests that glutathione cannot be optimally synthesized and replenished.Whilst alterations of the enterohepatic circulation of bile acids in pediatric IBD patients is known,we show here that non-invasive urinary bile acid profiling can assess those altered hepatic and intestinal barrier dysfunctions.CONCLUSIONThe present study shows how non-invasive sampling of urine followed by targeted MS-based metabonomic analysis can elucidate and monitor the metabolic status of children with different GI health/disease status.	Francois-Pierre Martin Ming-Ming Su Guo-Xiang Xie Seu Ping Guiraud Martin Kussmann Jean-Philippe Godin Wei Jia Andreas Nydegger	2017	World Journal of Gastroenterology2017，23，20：	2
2	A comparative biomechanical investigation of anterior lumbar interbody cages:central and bilateral approaches 显示文摘	Oxland TR Hoffer Z Nydegger T	2000	J Bone Joint Surg Am2000，82，3：	1
3	A spiral implant as nucleus prosthesis in the lumbar spine显示文摘	Korge A Nydegger T Polard JL		0，，2：	1
4	A comparative biomechanical investigation of anterior lumbar interbody cages:central and bilateral approaches显示文摘	Hoffer Z Nydegger T el al	2000	J Bone Joint Surg Am2000，82，3：	1
5	Three-dimensional stabilization provided by the external spinal fixator compared to two internal fixation devices: a biomechanical in vitro flexibility study 显示文摘	Lund T Nydegger T Rathonyi G	2003	EurSpineJ2003，12，5：	1
6	Effects of calcium supplem ents on femoral bone mineral density and vertebral fracture rate in vitamin-D- replete elderly patients显示文摘	Chevalley T Rizzoli R Nydegger V	1994	Osteoporos Int1994，4，：	1
7	Influence of adynamic stabilization system on load bearing of a bridged disc:an in vitro study of intradiscal pressure显示文摘	Schmoelz W Huber JF Nydegger T	2006	Eur Spine J2006，15，8：	1
8	Varia tion in nitrate metabolism in biovars of Pseudomonas solanacearum显示文摘	Hayward A C El-Nashaar H M Nydegger U	1990	J Appl Bacteriol1990，69，：	1
9	Dynamic stabilizationof the lumbar spine and its effects on adjacent segments:an invitro experiment显示文摘	Schmoelz W Huber JF Nydegger T	2003	J Spinal Disord Tech2003，16，4：	1
10	Variation in nitrate metabolism in biovars of Pseudomonas solanaceannn显示文摘	Hayward A C E1-Nashaar H M Nydegger U	1990	J Appl Bacteriol1990，，69：	1
11	Dynamic stabili- zation of the lumbar spine and its effects on adjacent segments: an in vitro experiment 显示文摘	Schmoelz W Huber JF Nydegger T	2003	J spinal Disord Tech2003，16，4：	1
12	Serum erythropoietin in heart failure patients treated with ACE-inhibitors or AT1 antagonists 显示文摘	Chatterjee B Nydegger UE Mohacsi P	2000	Eur JHeart Fail2000，2，4：	1
13	Influence of a dynamic tabilization system on load bearing of a bridged disc: an in vitro study of intradiscal pressure 显示文摘	Schmoelz W Huber JF Nydegger T	2006	Eur Spine J2006，15，8：	1
14	Childhood pancreatitis显示文摘	Nydegger A Couper RT Oliver MR	2006	J Gastroenterol Hepatol2006，21，3：	1
15	Influence of a dynamic stabilisation system on load bearing of a bridged disc: an in vitro study of intradiscal pressure 显示文摘	Schmoelz W Huber JF Nydegger T	2006	Eur Spine J2006，15，8：	1
16	Dynamic stabilization of the lumbar and its effects on adjacent segment:an in vitro experi- ment显示文摘	Schmoelz W Huber JF Nydegger T etal	2003	J Spine Disord Tech2003，16，：	1
17	Dynamic stabilization of the lumbar spine and its effects on adjacent segments:an in vitro experiment显示文摘	Schmoelz W Huber JF Nydegger T		0，，04：	1
18	Serum erythropoietin in heart failure patients treated with ACE-inhibitors or AT(1) antagonists显示文摘	Chatterjec B Nydegger UE Mohacsip P	2000	Eur J Heart Fail2000，2，4：	1
19	Changes in resting energy expenditure in children with congenital heart disease显示文摘	Nydegger A Walsh A Penny DJ	2009	EurJ Clin Nutr2009，63，3：	1
20	A comparative biomechanical investigation of anterior lumbar interbody cages:central and bilateral approaches显示文摘	Oxland TR Hoffer Z Nydegger T	2000	J Bone Joint Surg (Am)2000，83，3：	1

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