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| 1 | Comparison of novel and standard diagnostic tools for the detection of Schistosoma mekongi infection in Lao People’s Democratic Republic and Cambodia显示文摘Background:Given the restricted distribution of Schistosoma mekongi in one province in Lao People’s Democratic Republic(Lao PDR)and two provinces in Cambodia,together with progress of the national control programmes aimed at reducing morbidity and infection prevalence,the elimination of schistosomiasis mekongi seems feasible.However,sensitive diagnostic tools will be required to determine whether elimination has been achieved.We compared several standard and novel diagnostic tools in S.mekongi-endemic areas.Methods:The prevalence and infection intensity of S.mekongi were evaluated in 377 study participants from four villages in the endemic areas in Lao PDR and Cambodia using Kato-Katz stool examination,antibody detection based on an enzyme-linked immunosorbent assay(ELISA)and schistosome circulating antigen detection by lateral-flow tests.Two highly sensitive test systems for the detection of cathodic and anodic circulating antigens(CCA,CAA)in urine and serum were utilized.Results:Stool microscopy revealed an overall prevalence of S.mekongi of 6.4%(one case in Cambodia and 23 cases in Lao PDR),while that of Opisthorchis viverrini,hookworm,Trichuris trichiura,Ascaris lumbricoides and Taenia spp.were 50.4%,28.1%,3.5%,0.3%and 1.9%,respectively.In the urine samples,the tests for CCA and CAA detected S.mekongi infections in 21.0%and 38.7%of the study participants,respectively.In the serum samples,the CAA assay revealed a prevalence of 32.4%,while a combination of the CAA assay in serum and in urine revealed a prevalence of 43.2%.There was a difference between the two study locations with a higher prevalence reached in the samples from Lao PDR.Conclusions:The CCA,CAA and ELISA results showed substantially higher prevalence estimates for S.mekongi compared to Kato-Katz thick smears.Active schistosomiasis mekongi in Lao PDR and Cambodia might thus have been considerably underestimated previously.Hence,sustained control efforts are still needed to break transmission of S.mekongi.The pivotal role of highly sensitive diagnostic assays in areas targeting elimination cannot be overemphasised. | Youthanavanh Vonghachack Somphou Sayasone Virak Khieu Robert Bergquist Govert Jvan Dam Pytsje THoekstra Paul L.A.M.Corstjens Beatrice Nickel Hanspeter Marti Jürg Utzinger Sinuon Muth Peter Odermatt | 2017 | Infectious Diseases of Poverty2017，6，1： | 4 |
| 2 | Effect of housing conditions on production, carcass and meat quality traits of growing rabbits显示文摘 | Zs. Matics Zs. Szendr? M. Odermatt Zs. Gerencsér I. Nagy I. Radnai A. Dalle Zotte | 2013 | Meat Science2013，，： | 2 |
| 3 | Roles of tumor location, second signals and cross priming in cytotoxic T-cell induction显示文摘 | OCHSENBEIN AF SIERRO S ODERMATT B | 2001 | Nature2001，411，6841： | 2 |
| 4 | Transmission of Opisthorchis viverrini,Schistosoma mekongi and soil-transmitted helminthes on the Mekong Islands,Southern Lao PDR显示文摘Background:Prevalence of Opisthorchis viverrini,Schistosoma mekongi and soil-transmitted helminths(STH)remains high in Lao People’s Democratic Republic(Lao PDR),despite control efforts including mass-drug administration,education and communication campaigns.New approaches are required to advance helminth control.Methods:An ecohealth study was conducted on two Mekong islands in Southern Laos.Demographic and behavioural data were collected by questionnaire.Human and animal reservoir stools were examined.Bithynia spp.and Neotricula aperta snails were examined using shedding.Fresh water fish were examined using digestion technique.Multivariate random-effects analysis was used to find risk factors associated with helminth infections.Results:Human infection rates with O.viverrini,hookworm,S.mekongi,Trichuris trichiura,Ascaris lumbricoides and Taenia spp.were 60.7%,44.1%,22.2%,4.1%,0.6%and 0.1%,respectively.Heavy intensity infections were 4.2%,3.6%and 1.8%for O.viverrini,S.mekongi and hookworm,respectively.O.viverrini and S.mekongi infection rates among dogs and cats were 25.0%and 14.7%,respectively.Of the cats tested,53.1%were infected with O.viverrini.Prevalence of O.viverrini and S.mekongi in snails was 0.3%and 0.01%,respectively.Overall prevalence of O.viverrini infection in fresh water fish was 26.9%,with the highest infection rates occurring in Hampala dispa(87.1%),Cyclocheilichthys apogon(85.7%)and Puntius brevis(40.0%).Illiteracy and lower socioeconomic status increased the risk of O.viverrini infection,while those aged 10-16 years and possessing latrines at home were less likely to be infected.Household dogs and cats that consumed raw fish were significantly and positively associated with O.viverrini infection of the household members.For S.mekongi,children under 9 years old were exposed significantly to this infection,compared to older age groups.Conclusions:There is a pressing need to design and implement an integrated helminth control intervention on the Mekong Islands in southern Lao PDR.Given the highly dynamic transmission of O.viverrini,S.mekongi,STH and extended multiparasitism,annual mass-drug administration is warranted along with environmental modifications,health education and improved access to clean water and adequate sanitation to consolidate morbidity control and move towards elimination.Trail registration number:Our findings presented here are from a cross-sectional study,therefore,it has not been registered. | Youthanavanh Vonghachack Peter Odermatt Keoka Taisayyavong Souphanh Phounsavath Kongsap Akkhavong Somphou Sayasone | 2017 | Infectious Diseases of Poverty2017，6，1： | 2 |
| 5 | Use of high tempera- ture resistant chelants in peroxide bleaching of kraft pulps显示文摘 | JASCHINKSI T ODERMATT J PATT R | 1998 | Pulp and Paper Canada1998，99，8： | 1 |
| 6 | Electromyography of sco- liotic patients treated with a brace显示文摘 | Odermatt D Mathieu PA Beausejour M | 2003 | J Orthop Res2003，21，5： | 1 |
| 7 | Application of a catalyst in peroxide bleaching of eucalyptus Kraft pulp显示文摘 | Kuhne L Odermatt J Wachter T | 2000 | Holzforschung2000，54，： | 1 |
| 8 | Endobronchial ultrasound in hilar and conventional TBNA-negative/inconclusive mediastinal lymphadenopathy显示文摘 | Chhajed PN Odermatt R Von Gamier C | 2011 | J Cancer Res Ther2011，7，2： | 1 |
| 9 | Clodronate-liposome-mediated depletion of tumour-associated macrophages:a new andhighly effective antiangiogenic therapy approach显示文摘 | Zeisberger SM Odermatt B Marty C | 2006 | Br J Cancer2006，95，3： | 1 |
| 10 | Tissue-specific modulation of mine-ralocorticoid receptor function by 11 β-hydroxysteroiddehydrogenas-es:an overview显示文摘 | Odermatt A Kratschmar DV | 2012 | Mol Cell Endocrinol2012，350，2： | 1 |
| 11 | A hydrogel for adhesion prevention:characterization and efficacy study in a rabbit uterus model显示文摘 | Müller SA Weis C Odermatt EK | | 0，，01： | 1 |
| 12 | Sizing snow grains using backscattered solar light显示文摘 | A. Kokhanovsky V. V. Rozanov T. Aoki D. Odermatt C. Brockmann O. Krüger M. Bouvet M. Drusch M. Hori | 2011 | International Journal of Remote Sensing2011，，22： | 1 |
| 13 | The Western-style diet: a major risk factor for impaired kidney function and chronic kidney disease 显示文摘 | Odermatt A | 2011 | Am J Physiol Renal Physiol2011，301，5： | 1 |
| 14 | Short- and long-term outcomes after laparoscopic vemus open emergency resection for co- lon cancer: an observational propensity score-matched study 显示文摘 | Odermatt M Miskovic D Siddiqi N | 2013 | World J Surg2013，37，10： | 1 |
| 15 | Primary structure of two P-type ATPases involved in copper homeostasis in Enterococcus hirae 显示文摘 | Odermatt A | 1993 | Biol Chem1993，268，12： | 1 |
| 16 | Cytotoxie targeting of F9 teratoearcinoma turnouts with anti-ED-B fibronectin seFv antibody modified liposomes显示文摘 | Marty C Odermatt B Schott H | 2002 | Br J Cancer2002，87，1： | 1 |
| 17 | ICAM-1 triggers liver regeneration through leukocyte recruitment and Kupffer cell-dependent release of TNF-alpha/IL-6 in mice显示文摘 | Selzner M Odermatt B | 2003 | Gastroenterology2003，124，： | 1 |
| 18 | Copper and silver transport by copB-ATPase in membrane vesicles of Enterococcus hirae 显示文摘 | Sohoz M Odermatt A | 1995 | Biol Chem1995，270，： | 1 |
| 19 | TNF receptor 1 -dependent beta cell toxicity as an effector pathway in autoimmune diabetes显示文摘 | Kagi D Ho A Odermatt B | 1999 | J Immunal1999，162，8： | 1 |
| 20 | The glucocorticoid-aetivating enzyme l lbeta-hydroxysteroid dehydrogenase type 1 has broad substrate specificity : Physiological and toxicological considerations 显示文摘 | Odermatt A Nashev LG | 2010 | J Steroid Biochem Mol Bio|2010，119，12： | 1 |
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