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| 1 | Lignan glucoside from Sinopodophyllum emodi and its cytotoxic activity显示文摘新 lignan glycoside 从根的 n-butanol 摘录和 Sinopodophyllum emodi 的根茎被孤立。根据光谱证据,它的结构作为 4,5-didemethylpodophyllotoxin 被证实并且称为 7-O--d-glucopyranoside。这混合物在 vitro 对四根人的癌症房间线(Hela, K562, SH-SY5Y 和 CNE ) 显示出 cytotoxicity。 | Chang Qi Zhao Yan Yan Zhu Shu Ying Chen Yukio Ogihara | 2011 | Chinese Chemical Letters2011,22,2: | 6 |
| 2 | Autofluorescence imaging endoscopy for identifi cation and assessment of inflammatory ulcerative colitis显示文摘AIM:To validate the clinical relevance of autofluores-cence imaging(AFI)endoscopy for the assessment of inflammatory ulcerative colitis(UC).METHODS:A total of 572 endoscopic images were se-lected from 42 UC patients:286 taken with white light imaging(WLI)and 286 with AFI from the same sites.WLI images were assessed for overall mucosal inflammation according to Mayo endoscopic subscore(MES),and for seven characteristic endoscopic features.Likewise,AFI photographs were scored according to relative abundance of red,green and blue color com-ponents within each image based on an RGB additive color model.WLI and AFI endoscopic scores from the same sites were compared.Histological evaluation of biopsies was according to the Riley Index.RESULTS:Relative to red(r=0.52,P<0.01)or blue(r=0.56,P<0.01)color component,the green color component of AFI(r=-0.62,P<0.01)corresponded more closely with mucosal inflammation sites.There were signif icant differences in green color components between MES-0(0.396±0.043)and MES-1(0.340± 0.035)(P<0.01),and between MES-1 and ≥ MES-2(0.318±0.037)(P<0.01).The WLI scores for 'vascu-lar patterns'(r=-0.65,P<0.01),'edema'(r=-0.62,P<0.01),histology scores for 'polymorphonuclear cells in the lamina propria'(r=-0.51,P<0.01)and 'crypt architectural irregularities'(r=-0.51,P<0.01)showed correlation with the green color component of AFI.There were significant differences in green color components between limited(0.399± 0.042)and extensive(0.375±0.044)(P=0.014)polymorpho-nuclear cell inf iltration within MES-0.As the severity of the mucosal inflammation increased,the green color component of AFI decreased.The AFI green color com-ponent was well correlated with the characteristic en-doscopic and histological inflammatory features of UC.CONCLUSION:AFI has application in detecting inflammatory lesions,including microscopic activity in the co-lonic mucosa of UC patients,based on the green color component of images. | Taro Osada Atsushi Arakawa Naoto Sakamoto Hiroya Ueyama Tomoyoshi Shibuya Tatsuo Ogihara Takashi Yao Sumio Watanabe | 2011 | World Journal of Gastroenterology2011,17,46: | 5 |
| 3 | Differential Expression of Two Cytosolic Ascorbate Peroxidases and Two Superoxide Dismutase Genes in Response to Abiotic Stress in Rice显示文摘Superoxide dismutase (SOD) and ascorbate peroxidase (APX) play central roles in the pathway for scavenging reactive oxygen species in plants, thereby contributing to the tolerance against abiotic stress. Here we report the responses of cytosolic SOD (cSOD; sodCc1 and sodCc2) and cytosolic APX (cAPX; OsAPX1 and OsAPX2) genes to oxidative and abiotic stress in rice. RNA blot analyses revealed that methyl viologen treatment caused a more prominent induction of cAPXs compared with cSODs, and hydrogen peroxide treatment induced the expression of cAPXs whereas cSODs were not affected. These results suggest that cAPXs play more important roles in defense against oxidative stress compared with cSODs. It is noted that cSODs and cAPXs showed coordinate response to abscisic acid treatment which induced both sodCc1 and OsAPX2. However, cSODs and cAPXs responded differentially to drought, salt and chilling stress, which indicates that cSOD and cAPX genes are expressed differentially in response to oxidative and abiotic stress in rice. | Shigeto MORITA Shinya NAKATANI Tomokazu KOSHIBA Takehiro MASUMURA Yasunari OGIHARA Kunisuke TANAKA | 2011 | Rice science2011,18,3: | 3 |
| 4 | Periostin as a Novel Factor Responsible for Ventricular Dilation显示文摘 | Naruto Katsuragi Ryuichi Morishita Noriko Nakamura Tayehito Ochiai Yoshiaki Taniyama Yasuhiro Hasegawa Kayoko Kawashima Yasufumi Kaneda Toshio Ogihara Keijiro Sugimura | 2004 | Circulation2004,,13: | 2 |
| 5 | Parallel Data Mining for Association Rules on Shared-Memory Systems显示文摘 | S. Parthasarathy M. J. Zaki M. Ogihara W. Li | 2001 | Knowledge and Information Systems2001,,1: | 2 |
| 6 | Association of Methylenetetrahydrofolate Reductase Gene Polymorphism With Carotid Atherosclerosis Depending on Smoking Status in a Japanese General Population显示文摘 | Nozomu Inamoto Tomohiro Katsuya Yoshihiro Kokubo Toshifumi Mannami Takashi Asai Shunroku Baba Jun Ogata Hitonobu Tomoike Toshio Ogihara | 2003 | Stroke: Journal of the American Heart Association2003,,7: | 2 |
| 7 | Bloody cerebrospinal fluid alters contractility of cultured arteries显示文摘 | Ogihara K Tumu P | 1999 | Neurol Res1999,21,6: | 1 |
| 8 | Structural transformation of saikosaponins by gastric juice and intestinal flora显示文摘 | SHIMIZU K AMAGAYA S OGIHARA Y | 1985 | J Pharmacobiodyn1985,8,9: | 1 |
| 9 | Effect of shosaikoto,a japanese ane Chinese herbalmedicinal mixture on the mitogenic activity of lipopolysaccharide,a new pharmacological testing method显示文摘 | Hrioko Iwama Sakae Amagaya Yukio Ogihara | 1987 | J Ethnohparmacol1987,211,: | 1 |
| 10 | Effect of shosaikoto,a japanese and Chinese herbalmedicinal mixture on the mitogenic activity of lipopolysaccharide, a new pharmacologicaltesting method显示文摘 | Hfioko lwama Sakae Amagaya Yukio Ogihara | 1987 | J Ethnohparmacol1987,211,: | 1 |
| 11 | Ni/SiO2 catalyst effective for methane decomposition into hydrogen and carbon nanofiber显示文摘 | Takenaka S Kobayashi S Ogihara H | 2003 | J Catal2003,217,1: | 1 |
| 12 | Effect of shosaikoto a Japanese and chinese traditional herbal medical minture,on the initogenic activity of lipopolysaccharide: a new pharmacological testing methed 显示文摘 | Iwama H Amagaya S Ogihara Y | 1987 | J Ethnopharamcology1987,21,: | 1 |
| 13 | Applicability of inter-simple sequence repeat polymorphisms in wheat for use as DNA markers in comparison to RFLP and RAPD markers显示文摘 | Nagaoka T Ogihara Y 1997 | 1997 | Theoretical and Applied Genetics1997,93,: | 1 |
| 14 | Development of new class of ion conductive polymers based on ionic liquids 显示文摘 | Ohno H Yoshizawa M Ogihara W | 2004 | Electrochim Acta2004,50,23: | 1 |
| 15 | Angiotensin II Type 1 Receptor B- locker Reduces Monocyte Adhesion to Endothelial Cells in spontaneo- usly hypertensive rats显示文摘 | lkeda F Azuma K Ogihara T | 2007 | Endocrine Journal2007,54,4: | 1 |
| 16 | Technology for reducing engine rubbing resistance by means of surface improvement显示文摘 | Ogihara H | 2000 | HONDA R&D Technical Review2000,12,2: | 1 |
| 17 | Corticosteroid pulse combination therapy for refractory Kawasaki disease:A randomized trial显示文摘 | Ogata S Ogihara Y Honda T | | 0,,01: | 1 |
| 18 | Effect of boron content and crystalline structure on hardness in electrodeposited Ni-B alloy films 显示文摘 | Ogihara H Udagawa K Saji T | 2012 | Surface ~ Coatings Technology2012,206,1112: | 1 |
| 19 | Phylogenetic affinities of the grasses to other monocots as revealed by molecular analysis of chloroplast DNA显示文摘 | Katayama H Ogihara Y | 1996 | Current Genetics1996,20,: | 1 |
| 20 | Antihypertensive efficacy and safety of fixed-dose combination therapy with losartan plus hydrochlorothiazide in Japanese patients with essential hypertension显示文摘 | Saruta T Ogihara T Matsuoka H | 2007 | Hypertens Res2007,30,8: | 1 |