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| 1 | 北京市老年人健康预期寿命及其变化显示文摘目的 了解北京地区老年人的健康预期寿命和变化。方法 采用纵向研究方法对北京城区(宣武区)、郊区(大兴区)和山区(怀柔县)一个有代表性老年人群(3257人)进行了12年追踪,调查其健康和存活状况。用WHO的基本生活能力评估量表(ADL),评估老年人躯体功能健康状况及变化,采用IMaCH多状态法分析多次调查结果及不同健康状况的转变,计算老年人的健康预期寿命及不同时段的变化。结果 纵向结果显示一些基本特征在不同时段维持不变:老年人的平均预期寿命(LE)、健康预期寿命(ALE)和健康预期寿命比值(ALE/LE)在城区显著高于农村;女性平均预期寿命高于男性,但ALE/LE低于男性。纵向观察的变化表现为:老年人的平均预期寿命有所提高,增加的幅度在农村大于城区,男性大于女性;城区高龄女性老年人的健康预期寿命近年有明显下降;所有老年人的ALE/LE近年呈下降趋势,尤其是城区老年人和高龄老年人更突出。结论 北京地区老年人的健康预期寿命未与预期寿命同步增长,加强心脑血管疾病等慢性病防治,预防残疾和加强功能康复,是提高老年人健康预期寿命和生活质量的基础。 | 汤哲 项曼君 Zachary Zimmer 方向华 Toshiko Kaneda | 2005 | 中华流行病学杂志2005，26，12： | 40 |
| 2 | 北京市不同社会经济状况老年人的预期寿命和健康预期寿命显示文摘目的:了解北京老年群体中社会经济状况对人群预期寿命和健康预期寿命的影响。方法:样本来自北京老龄化纵向研究,对象为北京市城区(宣武)、近郊(大兴)、远郊(怀柔)55岁以上的人群,1992年基线调查3257例,由经过培训的调访员入户作问卷调查。1994,1997年对该样本随访,了解存活和健康状况。根据能否独立完成日常生活活动(ADL)认定功能健康与否。社会经济状况(socioeconomicstatus,SES)的指标选用教育、收入、职业和家庭拥有财物4项,并均按两分法分为高、低两水平,根据基线调查结果区分每人的各指标所在的高、低位置。利用IMaCH软件多状态生命表法计算预期寿命(lifeexpectancy,LE)、健康预期寿命(activelifeexpectancy,ALE)。结果:老年人LE和ALE男性均低与于女性,但男性ALE/LE高于女性。按不同指标计算,SES高水平者较低水平者男性LE增加20%~52%(延长2.1~5.77年)、女性增加4%~25%(延长0.6~4.3年),ALE男性增加30%~77%(延长2.1~4.0年)、女性增加5%~73%(延长0.6~5.6年)。不同指标与寿命相关的程度不同,男性中收入和财物拥有与ALE/LE的关系最大,女性以家庭财物拥有影响明显。高、低组间的差距随增龄加大。结论:北京市老年人中SES高水平的人较低SES水平的人,有更长的预期寿命和健康预期寿命和较高的ALE/LE? | 汤哲 Toshiko Kaneda 项曼君 方向华 Zachary Zimmer | 2004 | 中国临床康复2004，8，30： | 17 |
| 3 | Effects of heat treatments on microstructure and mechanical properties of Mg-15Gd-5Y-0.5Zr alloy显示文摘Microstructure and mechanical properties of Mg-15wt.%Gd-5 wt.%Y-0.5wt.% Zr alloy were investigated in a series of conditions. The eutectic was dissolved into the matrix and there was no evident grain growth after solutionized at 525 °C for 12 h. The evolution of the phase constituents from as-cast to cast-T4 was as follows: α-Mg solid solution+Mg5(Gd,Y) eutectic compound→α-Mg solid solution+ spheroidized Mg5(Gd, Y) phase→α-Mg supersaturated solid solution+cuboid-shaped compound (Mg2Y3Gd2). And the precipitation se- quences of Mg-15Gd-5Y-0.5Zr alloy were observed, according to the hardness response to isothermal ageing at 225-300 °C for 0-128 h. | 高岩 王渠东 顾金海 赵阳 童炎 Junya Kaneda | 2008 | Journal of Rare Earths2008，26，2： | 16 |
| 4 | DNA methylation in gastric cancer, related to Helicobacter pylori and Epstein-Barr virus显示文摘Gastric cancer is a leading cause of cancer death worldwide,and significant effort has been focused on clarifying the pathology of gastric cancer.In particular,the development of genome-wide analysis tools has enabled the detection of genetic and epigenetic alterations in gastric cancer;for example,aberrant DNA methylation in gene promoter regions is thought to play a crucial role in gastric carcinogenesis.The etiological viewpoint is also essential for the study of gastric cancers,and two distinct pathogens,Helicobacter pylori(H.pylori)and Epstein-Barr virus(EBV),are known to participate in gastric carcinogenesis.Chronic inflammation of the gastric epithelium due to H.pylori infection induces aberrant polyclonal methylation that may lead to an increased risk of gastric cancer.In addition,EBV infection is known to cause extensive methylation,and EBV-positive gastric cancers display a high methylation epigenotype,in which aberrant methylation extends to not only Polycomb repressive complex(PRC)-target genes in embryonic stem cells but also non-PRC-target genes.Here,we review aberrant DNA methylation in gastric cancer and the association between methylation and infection with H.pylori and EBV. | Keisuke Matsusaka Sayaka Funata Masashi Fukayama Atsushi Kaneda | 2014 | World Journal of Gastroenterology2014，20，14： | 12 |
| 5 | Segmental gastrectomy with radical lymph node dissection for early gastric cancer显示文摘AIM: To describe a new surgical technique and evaluate the early results of segmental gastrectomy (SG) with modified D2 lymph node (LN) dissection for early gastric cancer (EGC). METHODS: Fourteen patients with EGC underwent SG with modified D2 dissection from 2006 to 2008. Their operative results and postoperative courses were compared with those of 17 patients who had distal gastrectomy (DG) for EGC during the same period. RESULTS: Operating time, blood loss, and hospital stay were similar between the 2 groups. Postoperative complications developed significantly more frequently in the DG group than in the SG group. Mean number of dissected LNs per each station in the SG group was comparable with that in the DG group. Postoperative recovery of body weight was significantly better in the SG group than in the DG group. The incidence of reflux esophagitis and gastritis after surgery was less frequent in the SG group than in the DG group.CONCLUSION: SG with modified D2 LN dissection may be a new function-preserving gastrectomy that is feasible for treatment of EGC with possible LN involvement. | Takeru Matsuda Kunihiko Kaneda Manabu Takamatsu Keishi Aishin Masahide Awazu Akiko Okamoto Katsunori Kawaguchi | 2010 | World Journal of Gastroenterology2010，16，41： | 6 |
| 6 | Accumulation of aberrant DNA methylation during colorectal cancer development显示文摘Despite the recent advances in the therapeutic modalities,colorectal cancer(CRC)remains to be one of the most common causes of cancer-related death.CRC arises through accumulation of multiple genetic and epigenetic alterations that transform normal colonic epithelium into adenocarcinomas.Among crucial roles of epigenetic alterations,gene silencing by aberrant DNA methylation of promoter regions is one of the most important epigenetic mechanisms.Recent comprehensive methylation analyses on genome-wide scale revealed that sporadic CRC can be classified into distinct epigenotypes.Each epigenotype cooperates with specific genetic alterations,suggesting that they represent different molecular carcinogenic pathways.Precursor lesions of CRC,such as conventional and serrated adenomas,already show similar methylation accumulation to CRC,and can therefore be classified into those epigenotypes of CRC.In addition,specific DNA methylation already occurs in the normal colonic mucosa,which might be utilized for prediction of the personal CRC risk.DNA methylation is suggested to occur at an earlier stage than carcinoma formation,and may predict the molecular basis for future development of CRC.Here,we review DNA methylation and CRC classification,and discuss the possible clinical usefulness of DNA methylation as biomarkers for the diagnosis,prediction of the prognosis and the response to therapy of CRC. | Eiji Sakai Atsushi Nakajima Atsushi Kaneda | 2014 | World Journal of Gastroenterology2014，20，4： | 6 |
| 7 | En bloc pancreaticoduodenectomy and right hemicolectomy for locally advanced right-sided colon cancer显示文摘AIM To assess the usefulness of en bloc right hemicolectomy with pancreaticoduodenectomy(RHCPD) for locally advanced right-sided colon cancer(LARCC).METHODS We retrospectively reviewed the database of Saitama Medical Center, Jichi Medical University, between January 2009 and December 2016. During this time, 299 patients underwent radical right hemicolectomy for right-sided colon cancer. Among them, 5 underwent RHCPD for LARCC with tumor infiltration to adjacent organs. Preoperative computed tomography(CT) was routinely performed to evaluate local tumor infiltration into adjacent organs. During the operation, we evaluated the resectability and the amount of infiltration into the adjacent organs without dissecting the adherent organs from the cancer. When we confirmed that radical resection was feasible and could lead to R0 resection, we performed RHCPD. The clinical data were carefully reviewed, and the demographic variables, intraoperative data, and postoperative parameters were recorded.RESULTS The median age of the 5 patients who underwent RHCPD for LARCC was 70 years. The tumors were located in the ascending colon(three patients) and transverse colon(two patients). Preoperative CT revealed infiltration of the tumor into the duodenum in all patients, the pancreas in four patients, the superior mesenteric vein(SMV) in two patients, and tumor thrombosis in the SMV in one patient. We performed RHCPD plus SMV resection in three patients. Major postoperative complications occurred in 3 patients(60%) as pancreatic fistula(grade B and grade C, according to International Study Group on Pancreatic Fistula Definition) and delayed gastric empty. None of the patients died during their hospital stay. A histological examination confirmed malignant infiltration into the duodenum and/or pancreas in 4 patients(80%), and no patients showed any malignant infiltration into the SMV. Two patients were histologically confirmed to have tumor thrombosis in the SMV. All of the tumors had clear resection margins(R0). The median follow-up time was 77 mo. During this period, two patients with tumor thrombosis died from liver metastasis. The overall survival rates were 80% at 1 year and 60% at 5 years. All patients with node-negative status(n = 2) survived for more than seven years.CONCLUSION This study showed that the long-term survival is possible for patients with LARCC if RHCPD is performed successfully, particularly in those with node-negative status. | Yuji Kaneda Hiroshi Noda Yuhei Endo Nao Kakizawa Kosuke Ichida Fumiaki Watanabe Takaharu Kato Yasuyuki Miyakura Koichi Suzuki Toshiki Rikiyama | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 4 |
| 8 | 卒中对老年人预期寿命的影响及变化趋势显示文摘目的评价卒中对北京地区老年人预期寿命(LE)、健康预期寿命(ALE)和不健康预期寿命(IALE)的影响,以及上述各项预期寿命指标从1992-1997年到2000-2004年的变化趋势。方法采用纵向研究方法对北京市城区(宣武)、近郊区(大兴)和远郊区(怀柔)有代表性老年人群(3257例)进行12年追踪,调查其健康和存活状况。采用WHO的基本生活能力评估量表(ADL),评估老年人躯体功能健康状况及变化,采用SAS分析比较1992-1997年和2000-2004年2个时间段的LE、ALE和IALE变化。结果各年龄卒中组老年人的LE和ALE均低于非卒中组老年人,IALE则高于非卒中组。基线健康状态是ALE的重要决定因素—基线状态为健康的卒中组老年人,其ALE低于非卒中老年人,但是ALE长于IALE,且卒中组与非卒中组的1ALE无差异;而基线不健康的卒中老年人ALE大幅度减少,IALE超出ALE。城市卒中组老年人的LE和ALE均高于农村,而IALE低于农村。到2000-2004年间,无论城乡,是否患卒中,基线调查时是否处于健康状态,LE均有所增加,其中AEL的增加幅度高于IALE,基线不健康的卒中组老年人的ALE增加幅度最大。结论卒中减低老年人生命数量与质量,对于农村老年卒中患者更为明显。从1992-1997年到2000-2004年期间,北京地区无论是城市还是农村,卒中老年人的LE和ALE都有所延长,提示其生命数量和质量得到改善。 | 方向华 汤哲 Zachary Zimmer 项曼君 Toshiko Kaneda | 2009 | 中华流行病学杂志2009，30，2： | 4 |
| 9 | Hepatocyte growth factor gene therapy of liver cirrhosis in rats显示文摘 | Ueki T Kaneda Y Tsutsui H | | 0，，： | 3 |
| 10 | Periostin as a Novel Factor Responsible for Ventricular Dilation显示文摘 | Naruto Katsuragi Ryuichi Morishita Noriko Nakamura Tayehito Ochiai Yoshiaki Taniyama Yasuhiro Hasegawa Kayoko Kawashima Yasufumi Kaneda Toshio Ogihara Keijiro Sugimura | 2004 | Circulation2004，，13： | 2 |
| 11 | Thoracoscopic en bloc total esophagectomy with radical mediastinal lymphadenectomy显示文摘 | Takashi Akaishi Iwao Kaneda Norio Higuchi Yoshiki Kuriya Jun-ichi Kuramoto Tsuneo Toyoda Akio Wakabayashi | 1996 | The Journal of Thoracic and Cardiovascular Surgery1996，，6： | 2 |
| 12 | Stability of Posterior Spinal Instrumentation and Its Effects on Adjacent Motion Segments in the Lumbosacral Spine显示文摘 | Yasuhiro Shono Kiyoshi Kaneda Kuniyoshi Abumi Paul C. McAfee Bryan W. Cunningham | 1998 | Spine1998，，14： | 2 |
| 13 | Reversing liver cirrhosis: impact of gene therapy for liver cirrhosis显示文摘 | Fujimoto J Kaneda Y | | 0，，： | 2 |
| 14 | Induction of human cardiomyocyte-like cells from fibroblasts by defined factors显示文摘 | Rie Wada Naoto Muraoka Kohei Inagawa Hiroyuki Yamakawa Kazutaka Miyamoto Taketaro Sadahiro Tomohiko Umei Ruri Kaneda Tomoyuki Suzuki Kaichiro Kamiya Shugo Tohyama Shinsuke Yuasa Kiyokazu Kokaji Ryo Aeba Ryohei Yozu Hiroyuki Yamagishi Toshio Kitamura Keiic | 2013 | Proceedings of the National Academy of Sciences2013，，31： | 2 |
| 15 | Integrating GPS trajectory and topics from Twitter stream for human mobility estimation显示文摘Understanding urban dynamics and large-scale human mobility will play a vital role in building smart cities and sustainable urbanization. Existing research in this domain mainly focuses on a single data source (e.g., GPS data, CDR data, etc.). In this study, we collect big and heterogeneous data and aim to investigate and discover the relationship between spatiotemporal topics found in geo-tagged tweets and GPS traces from smartphones. We employ Latent Dirichlet Allocation-based topic modeling on geo-tagged tweets to extract and classify the topics. Then the extracted topics from tweets and temporal population distribution from GPS traces are jointly used to model urban dynamics and human crowd flow. The experimental results and validations demonstrate the efficiency of our approach and suggest that the fusion of cross-domain data for urban dynamics modeling is more practical than previously thought. | Satoshi MIYAZAWA Xuan SONG Tianqi XIA Ryosuke SHIBASAKI Hodaka KANEDA | 2019 | Frontiers of Computer Science2019，13，3： | 2 |
| 16 | Secondary Cell Wall Deposition in Developing Secondary Xylem of Poplar显示文摘Although poplar is widely used for genomic and biotechnological manipulations of wood, the cellular basis of wood development in poplar has not been accurately documented at an ultrastructural level. Developing secondary xylem cells from hybrid poplar (Populus deltoides x P. trichocarpa), which were actively making secondary cell walls, were preserved with high pressure freezing/freeze substitution for light and electron microscopy. The distribution of xylans and mannans in the different cell types of developing secondary xylem were detected with immunofluorescence and immuno-gold labeling. While xylans, detected with the monoclonal antibody LM10, had a general distribution across the secondary xylem, mannans were enriched in the S2 secondary cell wall layer of fibers. To observe the cellular structures associated with secondary wall production, cryofixed fibers were examined with transmission electron microscopy during differentiation. There were abundant cortical microtubules and endomembrane activity in cells during the intense phase of secondary cell wall synthesis. Microtubule-associated small membrane compartments were commonly observed, as well as Golgi and secretory vesicles fusing with the plasma membrane. | Minako Kaneda Kim Rensing Lacey Samuels | 2010 | Journal of Integrative Plant Biology2010，52，2： | 2 |
| 17 | Apoptotic DNA fragmentation and upregulation of Bax induced by transient ischemia of the rat retina显示文摘 | Katsuyuki Kaneda Satoshi Kashii Takayuki Kurosawa Shuji Kaneko Akinori Akaike Yoshihito Honda Masabumi Minami Masamichi Satoh | 1999 | Brain Research1999，，1： | 2 |
| 18 | Apoptotic DNA fragmentation and upregulation of Bax induced by transient ischemia of the rat retina显示文摘 | Kaneda K Kashii S Kurosawa T | 1999 | Brain Res1999，815，1： | 1 |
| 19 | Reperfusion-induced gene expression profiles in rat lung transplantation 显示文摘 | Yamane M Liu M Kaneda H | 2005 | Am J Transplant2005，5，9： | 1 |
| 20 | Differential mechanisms of constitutive Akt/PKB activation and its influence on gene expression in pancreatic cancer cells显示文摘 | MATSUMOTO J KANEDA M TADA M | 2002 | Jpn J Cancer Res2002，93，12： | 1 |
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