|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dietary polyphenols and colorectal cancer risk:The Fukuoka colorectal cancer study显示文摘AIM:To investigate the associations between dietary intake of polyphenols and colorectal cancer. METHODS:The study subjects were derived from the Fukuoka colorectal cancer study, a community-based case-control study. The study subjects were 816 cases of colorectal cancer and 815 community-based controls. The consumption of 148 food items was assessed by a computer-assisted interview. We used the consumption of 97 food items to estimate dietary intakes of total, tea and coffee polyphenols. The Phenol-Explorer database was used for 92 food items. Of the 5 foods which were not listed in the Phenol-Explorer Database, polyphenol contents of 3 foods (sweet potatoes, satoimo and daikon) were based on a Japanese study and 2 foods (soybeans and fried potatoes) were estimated by ORAC-based polyphenol contents in the United States Department of Agriculture Database. Odds ratios (OR) and 95%CI of colorectal cancer risk according to quintile categories of intake were obtained by using logistic regression models with adjustment for age, sex, residential area, parental history of colorectal cancer, smoking, alcohol consumption, body mass index 10 years before, type of job, leisure-time physical activity and dietary intakes of calcium and n-3 polyunsaturated fatty acids.RESULTS:There was no measurable difference in total or tea polyphenol intake between cases and controls, but intake of coffee polyphenols was lower in cases than in controls. The multivariate-adjusted OR of colorectal cancer according to quintile categories of coffee polyphenols (from the first to top quintile) were 1.00 (referent), 0.81 (95%CI:0.60-1.10), 0.65 (95%CI:0.47-0.89), 0.65 (95%CI:0.46-0.89) and 0.82 (95%CI:0.60-1.10), respectively (P trend = 0.07). Similar, but less pronounced, decreases in the OR were also noted for the third and fourth quintiles of total polyphenol intake. Tea polyphenols and non-coffee polyphenols showed no association with colorectal cancer risk. The sitespecific analysis, based on 463 colon cancer cases and 340 rectal cancer cases, showed an inverse association between coffee polyphenols and colon cancer. The multivariate-adjusted OR of colon cancer for the first to top quintiles of coffee polyphenols were 1.00 (referent), 0.92 (95%CI:0.64-1.31), 0.75 (95%CI:0.52-1.08), 0.69 (95%CI:0.47-1.01), and 0.68 (95%CI:0.46-1.00), respectively (P trend = 0.02). Distal colon cancer showed a more evident inverse association with coffee polyphenols than proximal colon cancer. The association between coffee polyphenols and rectal cancer risk was U -shaped, with significant decreases in the OR at the second to fourth quintile categories. There was also a tendency that the OR of colon and rectal cancer decreased in the intermediate categories of total polyphenols. The decrease in the OR in the intermediate categories of total polyphenols was most pronounced for distal colon cancer. Intake of tea polyphenols was not associated with either colon or rectal cancer. The associations of coffee consumption with colorectal, colon and rectal cancers were almost the same as observed for coffee polyphenols. The trend of the association between coffee consumption and colorectal cancer was statistically significant. CONCLUSION:The present findings suggest a decreased risk of colorectal cancer associated with coffee consumption. | Zhen-Jie Wang Keizo Ohnaka Makiko Morita Kengo Toyomura Suminori Kono Takashi Ueki Masao Tanaka Yoshihiro Kakeji Yoshihiko Maehara Takeshi Okamura Koji Ikejiri Kitaroh Futami Takafumi Maekawa Yohichi Yasunami Kenji Takenaka Hitoshi Ichimiya Reiji Terasaka | 2013 | World Journal of Gastroenterology2013，19，17： | 12 |
| 2 | Structure simulation in unidirectionally solidified turbine blade by dendrite envelope tracking model (Ⅱ): model validation and defects prediction显示文摘The developed model was validated by the checking of grain preferential growth orientation and the solidification experiment with low melting point alloy of Sn-21%Bi(mole fraction). It was also applied to predict the structure defects (e.g. stray grain) of unidirectionally solidified turbine blade. The results show that the developed model is reliable and has the following abilities: 1) reduce the misorientation caused by the orthogonal mesh used in simulation; 2) well reproduce the growth competition among the different-preferential-direction grains with less than 10% relative error; 3) predict the structure defect of stray grain with the accuracy over 80%; 4) optimize the grain selector to better obtain a single crystal avoiding the multigrain defect; 5) simulate the structure evolution (nucleation and growth) of the directional and single crystal turbine blade. | 王同敏 苏彦庆 郭景杰 I. OHNAKA H. YASUDA | 2006 | 中国有色金属学会会刊:英文版2006，16，4： | 4 |
| 3 | CYP1A1 , GSTM1 , GSTT1 and NQO1 polymorphisms and colorectal adenomas in Japanese men显示文摘AIM: To investigate the role of functional genetic poly-morphisms of metabolic enzymes of tobacco carcinogens in the development of colorectal adenomas. METHODS: The study subjects were 455 patients with colorectal adenomas and 1052 controls with no polyps who underwent total colonoscopy in a preretirement health examination at two Self Defense Forces hospitals. The genetic polymorphisms studied wereCYP1A1*2A (rs 4646903), CYP1A1*2C (rs 1048943), GSTM1 (null or non-null genotype), GSTT1 (null or non-null genotype) and NQO1 C609T (rs 1800566). Genotypes were determined by the polymerase chain reaction (PCR)-restriction fragment length polymorphism or PCR method using genomic DNA extracted from the buffy coat. Cigarette smoking and other life-style factors were ascertained by a self-administered questionnaire. The associations of the polymorphisms with colorectal adenomas were examined by means of OR and 95%CI, which were derived from logistic regression analysis. Statistical adjustment was made for smoking, alcohol use, body mass index and other factors. The gene-gene interaction and effect modification of smoking were evaluated by the likelihood ratio test. RESULTS: None of the five polymorphisms showed a significant association with colorectal adenomas, nor was the combination of GSTM1 and GSTT1 . A borderline significant interaction was observed for the combination of CYP1A1*2C and NQO1 (P = 0.051). The OR associated with CYP1A1*2C was significantly lower than unity among individuals with the NQO1 609CC genotype. The adjusted OR for the combination of the CYP1A1*2C allele and NQO1 609CC genotype was 0.61 (95%CI: 0.42-0.91). Although the interaction was not statistically significant (P = 0.24), the OR for individuals carrying the CYP1A1*2C allele and GSTT1 null genotype decreased significantly compared with those who had neither CYP1A1*2C allele nor GSTT1 null genotype (adjusted OR: 0.69, 95%CI: 0.49-0.97). Smoking did not modify the associations of the individual polymorphisms with colorectal adenomas. There was no measurable effect modification of smoking even regarding the combination of the genetic polymorphisms of the phaseⅠ and phase Ⅱ enzymes. CONCLUSION: Combination of the CYP1A1*2C and NQO1 609CC genotypes was associated with a decreased risk of colorectal adenomas regardless of smoking status. | Tadamichi Hamachi Osamu Tajima Kousaku Uezono Shinji Tabata Hiroshi Abe Keizo Ohnaka Suminori Kono | 2013 | World Journal of Gastroenterology2013，19，25： | 3 |
| 4 | Direct observation of stray crystal formation in unidirectional solidification of Sn–Bi alloy by X-ray imaging显示文摘 | Hideyuki Yasuda Itsuo Ohnaka Koichi Kawasaki Akira Sugiyama Tetsutaro Ohmichi Jun Iwane Keiji Umetani | 2003 | Journal of Crystal Growth2003，，1： | 2 |
| 5 | Alignment of BiMn crystal orientation in Bi-20at% Mn alloys by laser melting under a magnetic field 显示文摘 | Yasuda H Ohnaka I Yamamoto Y | 2003 | Materials Transactions2003，44，1： | 1 |
| 6 | Hot extrusion of rapidly solidified Al-Si alloy powder by the rotation-water-atomization process显示文摘 | YAMAUCHI I OHNAKA I KAWAMOTO S FUKUSAKO T | 1986 | Transactions of the Japan Institute of Metals1986，27，3： | 1 |
| 7 | Glucocorticoid suppresses the canonical Wnt signal in cultured human osteoblasts显示文摘 | Keizo Ohnaka Mizuho Tanabe Hisaya Kawate | 2005 | Biochem Biophys Res Commun2005，329，1： | 1 |
| 8 | Effect of magnetic field on solidification in Cu-Pb monotectic alloys显示文摘 | YASUDA H OHNAKA I KAWAKAMI O | 2003 | ISIJ International2003，43，6： | 1 |
| 9 | Pitavastatin enhanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts 显示文摘 | Ohnaka K Shimoda S Nawata H | 2001 | Biochem Biophys Res Commun2001，287，2： | 1 |
| 10 | Earthquake source nucleation: a physical model for short-term precursors 显示文摘 | Ohnaka M | 1992 | Tectonophysics1992，211，： | 1 |
| 11 | 05-xAlloys显示文摘 | Isamu Yamauchi Itsuo Ohnaka Effect of Rapid Solidification on Microstructure of Various Fe295-xSi7 | 2000 | Alloys and Compounds2000，12，： | 1 |
| 12 | Pathways of metas-tases from primary organs to the ovaries 显示文摘 | Yamanishi Y Koshiyama M Ohnaka M | 2011 | Obstet Gynecol Int2011，，： | 1 |
| 13 | Soy food and isoflavone intake and colorectal cancer risk: The Fukuoka Colorectal Cancer Study显示文摘 | Sanjeev Budhathoki Amit Man Joshi Keizo Ohnaka Guang Yin Kengo Toyomura Suminori Kono Ryuichi Mibu Masao Tanaka Yoshihiro Kakeji Yoshihiko Maehara Takeshi Okamura Koji Ikejiri Kitaroh Futami Takafumi Maekawa Yohichi Yasunami Kenji Takenaka Hitoshi Ichimiy | 2011 | Scandinavian Journal of Gastroenterology2011，，2： | 1 |
| 14 | Crystal orientation control of peritectic compound BiMn by magnetic field 显示文摘 | Yasuda H Ohnaka I | 1998 | CAMP-ISIJ1998，11，： | 1 |
| 15 | Constipation and colorectal cancer risk:the fukuoka colorectal cancer study显示文摘 | Tashiro N Budhathoki S Ohnaka K | 2011 | Asian Pac J Cancer Prev2011，12，8： | 1 |
| 16 | Preferred temperature of the elderly after cold and heat exposures determined by individual self-selection of air temperature 显示文摘 | Ohnaka Tadakatsu Tochihara Yutaka Tsuzuki Kazuyo | 1993 | Journal of Thermal Biology1993，18，56： | 1 |
| 17 | Bathing before sleep in the young and in the elderly显示文摘 | KANDA K TOCHIHARA Y OHNAKA T | 1999 | European Journal of Applied Physiology&Occupational Physiology1999，80，2： | 1 |
| 18 | Wnt signaling and glucocorticoid-induced osteoporosis显示文摘 | Ohnaka K | 2006 | Clin Calcium2006，16，11： | 1 |
| 19 | Glucocorticoid suppresses the canonical Wnt signal in cultured human osteoblasts显示文摘 | Ohnaka K Tanabe M Kawate H | | 0，，： | 1 |
| 20 | Modeling of mold filling of Al gravity casting and validation with X-ray in-situ observation显示文摘 | ZHAO Hai-dong Ohnaka Itsuo Zhu Jin-dong | 2008 | Applied Mathematical Modelling2008，32，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员