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| 1 | Need for infliximab dose intensification in Crohn's disease and ulcerative colitis显示文摘AIM: To compare the need for infliximab dose intensification in two cohorts of patients with Crohn's disease(CD) or ulcerative colitis(UC).METHODS: Single centre, uncontrolled, observational study. Consecutive patients with CD and UC who responded to infliximab induction doses were included. Data collected in a prospectively maintained database were retrospectively analysed. Differences in the rates of dose intensification per patient-month and the intensification-free survival time were compared. We also evaluated the interval between the first infliximab induction dose and the first infliximab escalated dose. The weight-adjusted infliximab administration costs were also calculated.RESULTS: Fifty nine patients with CD and 38 patients with UC were enrolled. The rate of intensification per patient-month was 3.9% for UC and 1.4% for CD(P = 0.005). The median time from baseline to intensification was significantly shorter in UC compared to CD [6.6 mo(IQR: 4.2-9.5 mo) vs 10.7 mo(IQR: 8.9-11.7 mo), P = 0.005]. In the survival analysis, the cumulative probability of avoiding infliximab dose intensification was significantly higher in CD(P = 0.002). In the multivariate analysis, disease(UC vs CD) was the only factor significantly associated with dose intensification. The infiximab administration costs during the first year were significantly higher for UC compared to CD(mean ± SD 234.9 ± 53.3 Euros/kg vs 212.3 ± 15.1 Euros/kg, P = 0.03).CONCLUSION: The rate of infliximab dose intensification per patient-month is significantly higher in UC patients. The infliximab administration costs are also significantly higher in patients with UC. | Carlos Taxonera David Olivares Juan L Mendoza Manuel Díaz-Rubio Enrique Rey | 2014 | World Journal of Gastroenterology2014，20，27： | 2 |
| 2 | A Centralized Energy Management System for Isolated Microgrids显示文摘 | OLIVARES D E CANIZARES C A KAZENRANI M | 2014 | IEEE Transactions on smart grid2014，5，4： | 1 |
| 3 | Determination of unsaturation grade and trans isomers generated during thermal oxidation of edible oils and fats by FTIR显示文摘 | MORENO M M C M OLIVARES M D LOPEZ A F J | 1999 | J Mol Struct1999，，： | 1 |
| 4 | Determination of unsaturation grade and trans isomers generated during thermal oxidation of edible oils and fats by P'TIR显示文摘 | MOYA MORENO C M MENDOZA OLIVARES D AMEZQUITA LOPEZ J V | 1999 | Journal of Molecular Structure1999，482，1： | 1 |
| 5 | Helicobacter pylori infection and gastric mucosal epithelial cell apoptosis显示文摘 | Olivares D Gisbert JP Pajares JM | 2005 | Rev Esp Enferm Dig2005，97，7： | 1 |
| 6 | Heat transfer analysis during water spray cooling of steel rods显示文摘 | MORALES R D LOPEZ A G OLIVARES I M | 1990 | ISIJ International1990，30，1： | 1 |
| 7 | Weight increase is associated with skeletal muscle immunostaining for advanced glycation end products, receptor for advanced glycation end products, and oxidation injury 显示文摘 | de la Maza MP Uribarri J Olivares D | 2008 | Rejuvenation Res2008，11，： | 1 |
| 8 | Experimental study of coal based directreduction in iron ore/coal composite pellets in a one layer bed under nonisothermal,asymmetric heating显示文摘 | Donskoi E Olivares R I Mcelwain D L S | 2006 | Ironmaking and Steelmaking2006，33，1： | 1 |
| 9 | Analytical evaluation of polyunsaturated fatty acids degradation during thermal oxidation of edible oils by Fourier transform infrared spectroscopy显示文摘 | Moya Moreno M C M Mendoza Olivares D Amezquita Lopez F J | 1999 | Talanta1999，50，2： | 1 |
| 10 | Antimicrobial potential of four Lactobacillus strains isolated from breast milk显示文摘 | Olivares M Díaz-Ropero MP Martín R | 2006 | J Appl Microbiol2006，101，1： | 1 |
| 11 | Determination of unsaturation grade and trans isomers generated during thermal oxidation of edible oils and fats by FTIR显示文摘 | MOYA MORENO M C M MENDOZA OLIVARE D S AMEZQUITA LOPEZ F J | 1999 | J Mol Struct1999，，： | 1 |
| 12 | Helicobacter pylori infection and gastric macosal epithelial cell apoptosis显示文摘 | Olivares D Gisbert JP Pajares JM | | 0，，07： | 1 |
| 13 | Immuno- logical changes at rectal mucosa in appendectomised subjects and inhabitants of developing countries 显示文摘 | OLIVARES D GISBERT J P GAMALLO C | 2007 | Gastroenterol Hepato12007，30，2： | 1 |
| 14 | Matter density perturbations in interacting quintessence models显示文摘 | OLIVARES G ATRIO-BARANDELA F PAVON D | 2006 | Phys Rev D2006，74，4： | 1 |
| 15 | Heat transfer analysis during water Spray cooling of steel rods显示文摘 | Morales R D Lopez A G Olivares I M | 1990 | ISIJ International1990，30，1： | 1 |
| 16 | Heat transfer analysis during water spray cooling of steel rods 显示文摘 | Morales R D Lopez A G Olivares I M | 1990 | ISLI Internation1990，30，1： | 1 |
| 17 | N-methyl-D-aspartate(NMDA)receptor antagonists and memantine treatment for Alzheimers disease,vascular dementia and Parkinsons disease显示文摘 | Olivares D K Deshpande V Shi Y K | 2012 | Curr Alzheimer Res2012，9，2： | 1 |
| 18 | A pyrano-isofla- vone from seeds of Milletiathonningii显示文摘 | Olivares E M Lwande W Monache F D | 1982 | Phytochemistry1982，21，7： | 1 |
| 19 | Controlled production of aligned-nanotubebundle显示文摘 | TERRONES M GROBERT N OLIVARES J ZHANG J P TERRONES H KORDATOS K HSU W K HARE J P TOWNSEND p D PRASSIDES K CHEETHAM A K KROTO HW WALTON D R M | 1997 | Nature1997，388，： | 1 |
| 20 | Analytical evaluation of polyunsaturated fatty acids degradation during thermal oxidation of edible oils by Fourier transform infrared spectroscopy 显示文摘 | M C M M Moreno D M Olivares F J A Lo'pez | 1999 | Talanta1999，，50： | 1 |
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