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| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study显示文摘 | Olivier Rixe Ronald M Bukowski M Dror Michaelson George Wilding Gary R Hudes Oliver Bolte Robert J Motzer Paul Bycott Katherine F Liau James Freddo Peter C Trask Sinil Kim Brian I Rini | 2007 | Lancet Oncology2007，，： | 2 |
| 3 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 4 | Application of the GRAPPA Psoriatic Arthritis Treatment Recommendations in Clinical Practice 显示文摘 | Aizad M Oliver F | 2010 | Curt Rheumatol Rep2010，12，4： | 1 |
| 5 | Effect of feed deprivation and lairage time on carcass and meat quality traits on pigs under minimal stressful conditions显示文摘 | Panella-Riera N Gispert M Gil M Soler J Tibau J Oliver M A Velarde A Fàbrega E | | 0，，01： | 1 |
| 6 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 7 | Hydrogenolysis of cellulose to valuable chemicals over actived carbon supported monoandbimetallic nickel/tungsten catalysts显示文摘 | KATERINA F OLIVER M MARTIN L PETER C | | Green Chem0，16，： | 1 |
| 8 | Marginal zone and B1 B cells unite in the early response against t-independent blood-borne particulate antigens 显示文摘 | MARTIN F OLIVER A M KEARNEY J F | 2001 | Immunity2001，14，5： | 1 |
| 9 | Special injection moulding processes in practical application显示文摘 | Oliver P Andreas F | 2000 | Kunststoffe Plast Europe2000，90，10： | 1 |
| 10 | A new approach for measurement of cytotoxicity using colorimetric assay显示文摘 | Hussain R F Nouri A M Oliver R T | 1993 | J Immunol Methods1993，160，1： | 1 |
| 11 | Densification of A1 powder and A1-Cu matrix composite (reinforced with 15 % Saffli short fibres) during axial cold compaction 显示文摘 | MORENO M F GONZ)tLEZ OLIVER C J R | 2011 | Powder Technology2011，206，： | 1 |
| 12 | On the generality of the relationship among contact stiffness, contact area, and elastic modulus duringindentation显示文摘 | Pharr G M Oliver W C Brotzen F R | 1992 | JMater Res1992，7，3： | 1 |
| 13 | Preparation and characterization of LaCrO~ and Cr2O~ methane combustion catalysts supported on LaAlll()18 and Al2Oa coated monoliths显示文摘 | Marcus F M Oliver H Menon P G | 1999 | Catalysis Today1999，47，： | 1 |
| 14 | Simulaneous detection and quantification of amphetamines,diazepam and its metabolites,cocaine and its metabolites,and opiates in hair by LC-ESI-MS-MS using a single extraction method显示文摘 | Miller E I Wylie F M Oliver J S | 2008 | Journal of Analytical Toxicology2008，32，： | 1 |
| 15 | 显示文摘 | Oliver R Ziyad M | 1995 | J Catal1995，157，： | 1 |
| 16 | A new approach for measurement of cytotoxicity using colorimetric assay 显示文摘 | Hussain R F Nouri A M Oliver R T | 1993 | J Immunol Methods1993，160，1： | 1 |
| 17 | The effect of RRA on the strength and SCC resistance on AA7050 and AA7150 alu-minium alloys 显示文摘 | Oliver A F Jr de Barros M C | 2004 | Materials Science and Engineering A2004，379，： | 1 |
| 18 | On the generality of the relationship among contact stiffness,contact area,and elastic modulus during indentation显示文摘 | Pharr G M Oliver W C Brotzen F R | 1992 | J Mater Res1992，7，3： | 1 |
| 19 | Developmentand evalua- tion of evidence - based risk assessmenttool (STRATIFY) to predict which elder inpatients willfall:case -control and co- hort studies 显示文摘 | Oliver D Brltton M Martin F | 1997 | Br Med J1997，315，7115： | 1 |
| 20 | On the generality of the relationship among contact stifness,contact area and elastic modulus during indentation显示文摘 | Pharr G M Oliver W C Brotzn F R | | 0，，03： | 1 |
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