|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | On the Measurement of Stress-strain Curves by Spherical Indentation显示文摘 | E G Herbert G M Pharr W C Oliver B N Lucas J L Hay | 2001 | Thin Solid Films2001，，： | 1 |
| 3 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 4 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 5 | Effects of Local Habitat Characteristics and Landscape Context on Grassland Butterfly Diversity 显示文摘 | Collinge S K Prudic K L Oliver J C | 2003 | Conservation Biology2003，17，1： | 1 |
| 6 | Determina-tion of carbonyl content in oxidatively modified pro-teins显示文摘 | Levine R L Garland D Oliver C N | 1990 | Methods in Enzymology1990，，： | 1 |
| 7 | Hydrogenolysis of cellulose to valuable chemicals over actived carbon supported monoandbimetallic nickel/tungsten catalysts显示文摘 | KATERINA F OLIVER M MARTIN L PETER C | | Green Chem0，16，： | 1 |
| 8 | Mutagenesis of varicella-zoster virus glycoprotein I (gI) identifies a cysteine residue critical for gE/gI heterodimer formation, gI structure, and virulence in skin cells 显示文摘 | Oliver SL Sommer MH Reichelt M Rajamani J Vlaycheva-Beisheim L Stamatis S Cheng J Jones C Zehnder J Arvin AM | 2011 | J Virol2011，85，9： | 1 |
| 9 | Volume changes during freezing of ductile iron 显示文摘 | BATES C E OLIVER G L MCSWAIN R H | 1977 | AFS Trans1977，85，： | 1 |
| 10 | Critical flow velocities for the growth and dominance of Anabaena circinalis in some turbid freshwater rivers显示文摘 | MITROVIC S M OLIVER R L REES C | 2003 | Freshwater Biology2003，48，： | 1 |
| 11 | Heterogeneity in radia- tioninduced DNA damage and repair in tumor and normal cells us- ing the' comet 'assay显示文摘 | OLIVE P L VIKSE C M DURAND R E | 1990 | Radiation Research1990，122，： | 1 |
| 12 | Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole ST Brosch R Parkhill J Garnier T Churcher C Harris D Gordon SV Eiglmeier K Gas S Barry CE Tekaia F Badcock K Basham D Brown D Chillingworth T Connor R Davies R Devlin K Feltwell T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Krogh A Mclean J Moule S Murphy L Oliver K Osborne J Quail MA Rajandream MA Rogers J Rutter S Seeger K Skelton J Squares R Squares S Sulston JE Taylor K Whitehead S Barrell BG | 1998 | Nature1998，393，6685： | 1 |
| 13 | Evolution and functions of long noncoding RNAs显示文摘 | PONTING C P OLIVER P L REIK W | 2009 | Cell2009，136，4： | 1 |
| 14 | 显示文摘 | Lasko C L Pesic B M Oliver D J | 1993 | J Appl Polym Sci1993，48，： | 1 |
| 15 | Staging of carcinoid tumours with 18 F-DOPA PET: a prospective, diagnostic accuracy study显示文摘 | Klaas P Koopmans Elisabeth GE de Vries Ido P Kema Philip H Elsinga Oliver C Neels Wim J Sluiter Anouk NA van der Horst-Schrivers Pieter L Jager | 2006 | Lancet Oncology2006，，9： | 1 |
| 16 | Gossypol acts directly on the mitochondria to overcome Bcl-2-and Bcl-X L mediated apoptosis resistance显示文摘 | Oliver C L Miranda M B Shangary S | 2005 | Mol Cancer Ther2005，4，1： | 1 |
| 17 | Creating proteins with novel functionality via the Maillard reaction : A review 显示文摘 | Oliver C M Melton L D Stanley R A | 2006 | Critical Reviews in Food Science and Nutrition2006，46，4： | 1 |
| 18 | V-Belt Life Prediction and Power Rating显示文摘 | Oliver L R Johnson C O Breig W F | | 0，，34： | 1 |
| 19 | Sexual selection and the adaptive evolution of mammalian ejaculate proteins显示文摘 | Ramm S A Oliver P L Ponting C P Stockley P Emes R D | | 0，，01： | 1 |
| 20 | Allelopathic potential of wheat (Triticum aestivum) straw on selected weed species显示文摘 | Steinsiek J W Oliver L R Collins F C | 1982 | Weed Science1982，30，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员