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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Evidence for a role of safieylie acid in the oxidative damage generated by NaCI and osmotic s tess in A rabi dopsis seedlings显示文摘 | Omar B Victoriano V Miguel A B | 2001 | Plant Physiol2001，126，： | 1 |
| 3 | Protein kinase B activity is required for the effects of insulin on lipid metabolism in adipocytes 显示文摘 | Berggreen C Gormand A Omar B | 2009 | Am J Physiol Endocrinol Metab2009，296，4： | 1 |
| 4 | Systematic re- view of oncological outcomes following surgical man agement of localised renal cancer显示文摘 | MacLennan S Imanmra M Lapitan M C Omar M I Lain T B Hilvano-Cabungcal A M | 2012 | Eur Urol2012，61，97： | 1 |
| 5 | Regulation of collagen synthesis by inhibitory Smad7 in cardiac myofibroblasts 显示文摘 | WANG B OMAR A ANGELOVSKA T | 2007 | Am J Physiol Heart Circ Physiol2007，293，： | 1 |
| 6 | Removal of Dyes and Industrial Dye Wastes by Magnesium Chloride 显示文摘 | Tan B H Teng T T Omar A K M | 2000 | Water Research2000，34，2： | 1 |
| 7 | Role of chloride ions on expansion and strength reduction in plain and blended cements in sulfate environments显示文摘 | OMAR Saeed Baghabra Al-Amoudi MOHAMMED Masiehuddin YASER A B Abdui-Al | 1995 | Constr Build Mater1995，9，1： | 1 |
| 8 | Regulation of collagen synthesis by inhibitory Smad7 in cardiac myofibroblasts显示文摘 | Omar A Angelovska T | 2007 | Am J Physiol Heart Circ Physiol2007，293，2： | 1 |
| 9 | Conserved MYC transcription factors play a key role in jasmonate signalling both in tomato and Arabidopsis 显示文摘 | MARTA B OMAR R R ASHRAF A | 2004 | Geges & Development2004，18，： | 1 |
| 10 | Rheological characteristics of Saudi crude oil emulsions 显示文摘 | OMAR A E DESOUKY S M KARAMA B | 1991 | Journal of Petroleum Science and Engineering1991，，6： | 1 |
| 11 | Application of a repetitive controller for a three-phase active power filter显示文摘 | Aurelio G C Omar P A Vicente F B | 2007 | IEEE Transactions on Power Electronics2007，22，1： | 1 |
| 12 | 显示文摘 | Omar N B Gonzalez-Munoz M T Penalver J M A | 1998 | Chemosphere1998，36，3： | 1 |
| 13 | Removal of dyes and industrial dye wastes by magnesium chloride显示文摘 | Tan B H Teng T T Omar A K M | 2000 | Wat Res2000，34，2： | 1 |
| 14 | Series Voltage Compensation for DFIG Wind Turbine Low-Voltage Ride-through Solution 显示文摘 | Omar A B Adel N | 2011 | IEEE Transactions on Energy Conversion2011，26，1： | 1 |
| 15 | An unusual cause of a double--lu- men endotracheal tube obstruction 显示文摘 | Abderrahmane B Omar A | 1999 | Anesthesia and Anal- gesia1999，，88： | 1 |
| 16 | Comparative heavy metal biosorption study of brewery yeast and Myxococcus xanthus biomass显示文摘 | OMAR N B MERROUN M L PENALVER J M A MUNOZ M T G | 1997 | Chemosphere1997，35，10： | 1 |
| 17 | Sistemas transcurrentes de escala litosferica en el Sur del Peru显示文摘 | Thierry S Javier J Victor C William M Conrado B Michel F Pierrick R Harmuth A Jorge A Luis C Alexander F Ivanoff I Omar L Mirian M Paola M Francis O Yovani O Adan P and Rildo R | | 0，，05： | 1 |
| 18 | Systematic re-view of perioperative and quality-of-life outcomes fol-lowing surgical management of localised renal cancer显示文摘 | MacLennan S Imamura M Lapitan M C Omar M I Lam T B Hilvano-Cabungcal A M | 2012 | Eur Urol2012，62，： | 1 |
| 19 | New centralized automatic vehicle location communications software system under GIS environment显示文摘 | Omar A B Balqies S | 2005 | International Journal of Communication Systems2005，18，9： | 1 |
| 20 | Role of chloride ions on expansion and strength reduction in plain and blended cements in sulfate environments显示文摘 | Omar S B A Mohammed M Yaser A B A | 1995 | Construction and Building Materials1995，9，1： | 1 |
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