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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Functional and safety aspects of enterococei isolated from different Spanish foods显示文摘 | Ben Omar N Castro A Lueas R | 2004 | Syst Appl Microbiol2004，27，1： | 1 |
| 3 | Resistance to antimicrobial agents in lactobacilli isolated from caper fermentations显示文摘 | PULIDO R P OMAR N B LUCAS R | 2005 | Antonie van Leeuwenhoek2005，88，34： | 1 |
| 4 | Lactobacillus acidophilus as a live vehicle for oral immunization against chicken anemia virus 显示文摘 | MOEINI H RAHIM R A OMAR A R | 2011 | Appl Mierobiol Biot2011，90，1： | 1 |
| 5 | Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer显示文摘 | Shaw R J Omar M M Rokadiya S | 2009 | British Journal of Cancer2009，101，1： | 1 |
| 6 | Complementary operators: a method to annihilate artificial reflections arising from the truncation of the computational domain in the solution of partial differential equations 显示文摘 | | 1995 | IEEE Transactions on Antennas and Propagation1995，43，3： | 1 |
| 7 | Cellular transcripts of chicken brain tissues in response to H5N1 and Newcastle disease virus infection显示文摘 | Balasubramaniam V R Wai T H Omar A R | | 0，，： | 1 |
| 8 | Enterocin AS-48RJ: a variant of enterocin AS-48 chromosomally encoded by Enterococcus faecium RJ16 isolated from food显示文摘 | Abriouel H Lucas R Omar NB | 2005 | Syst Appl Microbiol2005，28，5： | 1 |
| 9 | A leadless intracardiac transcatheter pacing system显示文摘 | Reynolds D Duray GZ Omar R | 2016 | N Engl J Med2016，374，6： | 1 |
| 10 | Another look at the single vendor singlebuyer integrated production-inventory problem 显示文摘 | Hill R W Omar M | 2006 | International Journal of Production Research2006，44，4： | 1 |
| 11 | Mitigation of voltage sags swells using dynamic voltage restores(DVR)显示文摘 | Omar R Rahim N A | 2009 | ARPN Journal of Engineering and- Applied Sci- ences2009，4，4： | 1 |
| 12 | Analysis of Amoxyeillin in Cpsules and Oral Suspensionsby High-performance Liquid Chromatography显示文摘 | Omar Shakoor Robert B Taylor Ronal R Moody | 1995 | Analyst1995，120，8： | 1 |
| 13 | Improved protection from velogenic Newcastle disease virus challenge following multiple immunizations with plasmid DNA encoding for F and HN genes显示文摘 | Loke C F Omar A R Rsha A R | 2005 | Vet Immunol Immunopathol2005，106，3： | 1 |
| 14 | Trends in prosthodontics显示文摘 | Carl n GE Omar R | 2006 | Med PrinPract2006，15，3： | 1 |
| 15 | Oral nifedipine versus intravenous labetalol for acute blood pressure control in hypertensive emergencies of pregnancy:a randomised trial显示文摘 | Raheem I A Saaid R Omar S Z | 2012 | BJOG:An International Journal of Obstetrics&Gynaecology2012，119，1： | 1 |
| 16 | PID plus fuzzy controller structures as a design base for industrial applications显示文摘 | LEONID R OMAR G | 2000 | Engineering Applications of Artificial Intelligence2000，13，： | 1 |
| 17 | False-positive F-18 FDG uptake in PET/CT studies in pediatric patients with abdominal Burkitt' s lymphoma显示文摘 | Riad R Omar W Sidhom I | 2010 | Nucl Med Commun2010，31，3： | 1 |
| 18 | Malaysiatin, the first cyclic heptapeptide from a marine sponge 显示文摘 | Fernandez R Omar S Feliz M | 1992 | Tetrahedrom Lett1992，33，： | 1 |
| 19 | Thrombophilic mutations in pre-eclampsia and pregnancy-induced hypertension 显示文摘 | Omar SZ Qvist R Khaing SL | 2008 | J Obstet Gynaecol Res2008，34，2： | 1 |
| 20 | Finite element analysis of dielectric scatterers using the absorbing boundary condition 显示文摘 | Ramahi R M | 1989 | IEEE Trans On Magnet1989，25，4： | 1 |
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