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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Interleukinl β polymorphisms increase risk of hypochlorhydira and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan显示文摘 | Furuta T El- Omar E Xiao F | 2002 | Gastroenterology2002，123，1： | 1 |
| 3 | High-sensitivity troponin I and amino-terminal pro-B-type natriuretic peptide predict heart failure and mortality in the generalpopulation 显示文摘 | Paul M Omar F Christopher G | 2014 | ClinChem2014，60，9： | 1 |
| 4 | Microfoaming of flax and wood fibre reinforced polypropylene composites显示文摘 | Bledzki A K Zhang W Y Omar F | 2005 | EuropeanJournal of Wood and Wood Products2005，63，1： | 1 |
| 5 | Polyphasic study of the spatial distribution of microorganisms in Mexican Pozol, a fer- mented maize dough, demonstrates the need for cultivation-inde- pendent methods to investigate traditional fermentations显示文摘 | Ampe F Ben Omar N Moizan C | 1999 | Ap- plied and Environmental Microbiology1999，，65： | 1 |
| 6 | Polyphasic study of the spatial distribution of microorganisms in Mexican Pozol, a fermented maize dough, demonstrates the need for cultivation-independent methods to investigate traditional fermentations 显示文摘 | Ampe F Ben Omar N Moizan C | 1999 | Applied and Environ Microbiol1999，65，： | 1 |
| 7 | Effects of the chemical foaming agents,injection,parameters,and melt-flow index on the microstruc-ture and mechanical properties of microcellular injection-molded wood-fiber/polypropylene composites显示文摘 | Bledzki A K Omar F | 2005 | Journal of AppliedPolymer Science2005，97，3： | 1 |
| 8 | The impact of inadequacies in the treatment of organizational issues on information systems development projects 显示文摘 | Doherty F Neil King Malcolm Al-Mushayt Omar | 2003 | Information & Management2003，41，： | 1 |
| 9 | Polyphasic study of the spatial distribution of microorganisms in Mexican pozol, a fermented maize dough demonsWates the need for cultivation-independent methods to investigate traditional fermentations 显示文摘 | AMPE F OMAR B N MO IZAN C | 1999 | Applied Environmental Microbiology1999，65，： | 1 |
| 10 | Autonomous over- head crane system using a fuzzy logic controller 显示文摘 | OMAR F KARRAY F BASIR O | 2004 | Jour- nal of Vibration and Control2004，，10： | 1 |
| 11 | Effects of metsulfur on methyl on amylase, urease and protease activities in two soils显示文摘 | lsmail B S Yapp K F Omar O | 2000 | Aust J SoilRes2000，，36： | 1 |
| 12 | Polyphasie Study of the Spatial Distribution of Microorganisms in Mexican Pozol, a Fermented Maize Dough, Demonstrates the Need for Cultivation-Independent Methods To Investigate Traditional Fermentations显示文摘 | Ampe F Omar N B Moizan C | 1999 | Appl Environ Microbiol1999，65，12： | 1 |
| 13 | Improved protection from velogenic Newcastle disease virus challenge following multiple immunizations with plasmid DNA encoding for F and HN genes显示文摘 | Loke C F Omar A R Rsha A R | 2005 | Vet Immunol Immunopathol2005，106，3： | 1 |
| 14 | Identification and characterization of a novel anti-viral peptide against avian influenza virus H9N2显示文摘 | Rajik M Jahanshiri F Omar AR | | 0，，： | 1 |
| 15 | Application of an eviden- tial belief function model in landslide susceptibility map- ping显示文摘 | Omar F A Biswajeet P Saro L | 2012 | Computers & Geosciences2012，，44： | 1 |
| 16 | Microbial Community Dynamics during Production of the Mexican Fermented Maize Dough Pozol 显示文摘 | Omar N B Ampe F | 2000 | Appl Environ Microbiol2000，66，9： | 1 |
| 17 | Injection moulded microcellular wood fibrepolypropylene composites 显示文摘 | Andrzej K B Omar F | 2006 | Compositesm ( Part A ) : Applied Science and Manufacturing2006，37，9： | 1 |
| 18 | Mathematical modeling of gearbox including defects with experimental verification显示文摘 | Omar F K Moustafa K A F Emam S | 2012 | Journal of Vibration and Control2012，18，9： | 1 |
| 19 | Nanoclay reinforced HDPE as a matrix for wood-plastic composites显示文摘 | Omar F Laurent M M | 2008 | Composites Science and Technology2008，68，： | 1 |
| 20 | Fast and robust fixed-point algorithms for independent component analysis显示文摘 | Abujarad F Jostingrneier A and Omar A S | 1999 | IEEE Transactions on Neural Networks1999，10，3： | 1 |
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