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| 1 | Circulating tumor and cancer stem cells in hepatitis C virusassociated liver disease显示文摘AIM:To assess the role of circulating tumor cells(CTCs)and cancer stem cells(CSCs)in hepatitis C virus(HCV)-associated liver disease.METHODS:Blood and/or tissue samples were obtained from HCV(genotype 4)-associated hepatocellularcarcinoma patients(HCC;n=120),chronic hepatitis C patients(CH;n=30)and 33 normal control subjects(n=33).Serum levels of alpha-fetoprotein(AFP),alkaline phosphatase,and alanine and aspartate aminotransferases were measured.Cytokeratin 19(CK19)monoclonal antibody was used to enumerate CTCs,and CD133 and CD90 were used to enumerate CSCs by flow cytometry.The expression levels of the CSCs markers(CD133 and CD90)as well as telomerase,melanoma antigen encoding gene 1(MAGE1)and MAGE3 were assessed by RTPCR and quantitative real-time polymerase chain reactions.The number of CTCs and/or the expression levels of CK19,CD133,telomerase,MAGE1 and MAGE3 were correlated to the standard clinicopathologic prognostic factors and disease progression.RESULTS:Levels of AFP,alkaline phosphatase and aspartate aminotransferase were significantly different among the HCC,CH and control groups(P<0.001),whereas alanine aminotransferase differed significantly between patient(HCC and CH)and control groups(P<0.001).At the specified cutoff values determine by flow cytometry,CK19(49.8),CD90(400)and CD133(73)were significantly higher in the blood of HCC patients compared to those in the CH and control groups(P<0.001).On the other hand,CD133 at a 69.5 cutoff was significantly higher in the CH compared to the control group(P≤0.001).Telomerase,MAGE1 and MAGE3RNA were expressed in 55.71%,60.00%and 62.86%of the HCC patients,respectively,but were not detected in patients in the CH or control groups,which were statistically significant(Ps<0.001).The expression levels of telomerase,CD90,MAGE3,CD133 and CK19 were all significantly associated with high tumor grade and advanced stage in HCC patients(all P s<0.05).CONCLUSION:CTC counts and AFP,CK19,telomerase,and MAGE1/MAGE3 expression predict disease progression in patients with HCV,whereas telomerase,MAGE3,CD90,CD133 and CK19 are prognostic mark- | Abeer A Bahnassy Abdel-Rahman N Zekri Ahmed El-Bastawisy Amal Fawzy Marwa Shetta Nehal Hussein Dalia Omran Abdallah A S Ahmed Samir S El-Labbody | 2014 | World Journal of Gastroenterology2014，20，48： | 9 |
| 2 | Rep-PCR characterization and biochemical selection of lactic acid bacteria isolated from the Delta area of Egypt显示文摘 | MOHAMMED M El-AZIZ H A OMRAN N | 2009 | International Journal of Food Microbiology2009，128，3： | 1 |
| 3 | Structure elucidation, protein pro- file and the antitumor effect of the biological active substance ex- tracted from sea cucumber holothuria polii 显示文摘 | OMRAN N E E KHEDR A M | 2015 | Toxicol Ind Health2015，31，1： | 1 |
| 4 | Development of an efficient catalyst from magnetite ore: characterization and catalytic potential in the ozonation of water toxic contaminants 显示文摘 | Moussavi G Khosravi R Omran N R | 2012 | Applied Catalysis A : General2012，，： | 1 |
| 5 | Location-based forecasting of vehicular charging load on the distribution system显示文摘 | Ghiasnezhad Omran N Filizadeh S | 2014 | IEEE Transactions on Smart Grid2014，5，2： | 1 |
| 6 | Political Connections and the Cost of Equity Capital 显示文摘 | Boubakri N Omrane O Dev M R | 2012 | Journal of Corporate Finance2012，，1： | 1 |
| 7 | Modeling depth-averaged velocity and boundary shear in trapezoidal channels with secondary flows显示文摘 | Knight D W Omran M Tang X N | 2007 | Journal of Hydraulic Engineering2007，133，1： | 1 |
| 8 | MicroRNAs 146a and 147b biomarkers for colorectal tumor's localization 显示文摘 | Omrane I Kourda N Stambouli N | 2014 | Biomed Res Int2014，2014，58： | 1 |
| 9 | A novel repair for patients with atrioventrieular septal defect requiring reoperation for left atrioventrieular valve regurgitation显示文摘 | Poirier N C Williams W G Van Arsdell G S Coles J G Small- horn J F Omran A | 2000 | Eur J Cardiothorac Surg2000，18，： | 1 |
| 10 | Myoloid-related protein 8, an endogenous ligand of Toll-like receptor 4, is involved in epileptogenesis of mesial temporal lobe epilepsy via activation of the nuclear factor-kappaB pathway in astrocytes 显示文摘 | Gan N Yang L Omran A | 2014 | Mol Neuro- biol2014，49，： | 1 |
| 11 | Development of an efficient catalyst from magnetite ore:Characterization and catalytic potential in the ozonation of water toxic contaminants显示文摘 | Moussavi G Khosravi R Omran N R | 2012 | Applied Catalysis A:General2012，445，： | 1 |
| 12 | Location-based forecasting of vehicular charging load on the distribution system显示文摘 | Ghiasnezhad Omran N Shahidinejad S | 2014 | IEEE Transactions on Smart Grid2014，5，2： | 1 |
| 13 | Positional effect of mutations in 5'UTR of hepatitis C virus 4a on patients' response to therapy显示文摘AIM:To investigate the effects of mutations in domain Ⅲ of the hepatitis C virus(HCV)internal ribosome entry sequences(IRES)on the response of chronic HCV genotype 4a patients to interferon therapy.METHODS:HCV RNA was extracted from 19 chronic HCV 4a patients receiving interferon/ribavirin therapy who showed dramatic differences in their response to combination therapy after initial viral clearance.IRES domainⅢ was cloned and 15 clones for each patient were sequenced.The obtained sequences were aligned with genotype 4a prototype using the ClustalW program and mutations scored.Prediction of stem-loop secondary structure and thermodynamic stability of the major quasispecies in each patient was performed using the MFOLD 3.2 program with Turner energies and selected constraints on base pairing.RESULTS:Analysis of RNA secondary structure revealed that insertions in domainⅢ altered WatsonCrick base pairing of stems and reduced molecular stability of RNA,which may ultimately reduce binding affinity to ribosomal proteins.Insertion mutations in domainⅢwere statistically more prevalent in sustained viral response patients(SVR,n=14)as compared to breakthrough(BT,n=5)patients.CONCLUSION:The influence of mutations within domainⅢ on the response of HCV patients to combination therapy depends primarily on the position,but not the frequency,of these mutations within IRES domain Ⅲ. | Mostafa K El Awady Hassan M Azzazy Ahmed M Fahmy Sherif M Shawky Noha G Badreldin Samar S Yossef Moataza H Omran Abdel Rahman N Zekri Said A Goueli | 2009 | World Journal of Gastroenterology2009，15，12： | 1 |
| 14 | Safety and efficacy of systemic methotrexate in the treatment of unruptured tubal pregnancy 显示文摘 | Soliman K- B Saleh N M Omran A A | 2006 | Saudi Meal J2006，27，7： | 1 |
| 15 | The gabbro(shos honitic)-monzonite-granodiorite association of Khankandi plu- ton,Alborz Mountains, NW Iran显示文摘 | Aghazadeh M Castro A Omran N R | 2010 | Journal of Asian Earth Sciences2010，38，： | 1 |
| 16 | Rep-PCR character- ization and biochemical selection of lactic acid bacteria isolated from the Delta area of Egypt显示文摘 | MOHAMMED M EL-AZIZ HA OMRAN N | 2009 | Int J Food Mierob2009，128，： | 1 |
| 17 | Myoloid-related protein 8,an en- dogenous ligand of Toll-like receptor 4,is involved in epilepto- genesis of mesial temporal lobe epilepsy via activation of the nuclear factor- ~ B pathway in astrocytes显示文摘 | Gan N Yang L Omran A | 2014 | Mot Neurobiol2014，49，1： | 1 |
| 18 | Myoloid-related protein 8, an endogenous ligand of Toll-like receptor 4, is in- volved in epileptogenesis of mesial temporal lobe epilepsy via activation of the nuclear factor-KB pathway in astro- cytes显示文摘 | Gan N Yang L Omran A | 2014 | Mol Neurobiol2014，49，1： | 1 |
| 19 | A study of en- dometritis causing repeat breeding of cycling Iraqi buffalo cows 显示文摘 | AZAWI O I OMRAN S N HADAD J J | 2008 | Reprod Domest Anita2008，43，： | 1 |
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