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| 1 | 大鼠戊四唑点燃模型的建立显示文摘给大鼠戊四唑(PTZ)亚惊厥剂量(30 mg/kg,ip),每日一次,连续给药28 d.建立了戊四唑化学点燃模型。采用七点评分法观察行为惊厥和脑电图变化。凡连续5次获二级或二级以上惊厥者,被认为完全点燃。结果表明,28 d龄大鼠总点燃率为74%,全身性肌阵挛为其典型症状。行为惊厥与脑异常放电同步。凡有行为惊厥者皆伴有恼电图棘波或棘慢波放电。停止处理4周后。点燃大鼠仍保持其点燃状态。提示本文所用PTZ剂量合理,方法可靠且简单易行。 | 王丽 J Ono PD Walson | 1993 | 药学学报1993，28，7： | 67 |
| 2 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 3 | Catalytic Properties of Low-valent Lanthanide Species Introduced into Y-Zeolite 显示文摘 | Baba T Kim G J Ono Y | 1992 | J Chem Soc Faraday Trans1992，88，6： | 2 |
| 4 | Increase in CPD photolyaseactivity functions effectively to prevent growth inhibition caused byUV-B radiation显示文摘 | HIDEMA J TAGUCHI T ONO T | 2007 | The Plant Journal2007，50，1： | 1 |
| 5 | Laparoscopic nephrectomy for renal cell cancer: evaluation of efficacy and safety: a multicenter experience 显示文摘 | CADEDDU J A ONO Y CLAYMAN B V | 1998 | Urology1998，52，5： | 1 |
| 6 | Prevention of postopera- :ire pulmonary complications through intensive preoperative :espiratory rehabilitation in patients with esophageal cancer 显示文摘 | Ono R Makiura D | 2013 | Dis Esophagus2013，26，1： | 1 |
| 7 | Interleukin-17 promotes angiogenesis and tumor growth显示文摘 | Numasaki M Fukushi J Ono M | 2003 | Blood2003，101，7： | 1 |
| 8 | Effects of sex hor-mones on Alzheimer’s disease-associated p-amyloid oligomerformation in vitro显示文摘 | Morinaga A Ono K Takasaki J | 2011 | Exp Neurol2011，228，2： | 1 |
| 9 | Interleukin -17 promotes angiogenesis and tumor growth显示文摘 | Numasaki M Fukushi J Ono M | 2003 | Blood2003，101，7： | 1 |
| 10 | Interleukin-17 promotes angiogenesis and tumor growth 显示文摘 | NUMASAKI M FUKUSHI J ONO M | 2003 | Blood2003，101，7： | 1 |
| 11 | Gamma knife radiosurgery for metastatic brain tumors from lung cancer:a comparison between small cell and non-small cell carcinoma显示文摘 | Serizawa T Ono J Iichi T | | 0，，5： | 1 |
| 12 | Clinical picture of intracranial nontraumatic dissecting aneurysm显示文摘 | Yamaura A Ono J Hirai S | | 0，，： | 1 |
| 13 | Synthesis and characterization of polyke- tones containing pendant carbazoles显示文摘 | Chen Zheng Ono Robert J Wiggins Kelly M | 2011 | Polymer2011，52，8： | 1 |
| 14 | Electrocorticographical observation of seizures induced by pentylenetetrazol injection in rats显示文摘 | Ono J Vieth RF Walson PD | 1990 | Functional Neurol1990，5，： | 1 |
| 15 | Role of H-K-ATPase in pHi regulation inner medullary collecting duct cells in culture显示文摘 | Ono S Gunlupalli J DuBose TD Jr | 1996 | Am J Physiol1996，270，52： | 1 |
| 16 | The activity of soluble VCAM-I in angiogenesis stimulated by IL-4 and IL-13 显示文摘 | Fukushi J Ono M Morikawa W | 2000 | J Immunol2000，165，： | 1 |
| 17 | Enantiomer separation by reversed - phase liquid chromatography with novel hydrophobic phases composed of chiral cationic surfactants 显示文摘 | KURATA K ONO J DOBASHI A | 2005 | J Chromatogr A2005，1080，： | 1 |
| 18 | Immunohistochemical localization of cathepsin D in colorectal tumors显示文摘 | Arao J Fukui H Ono Y | | 0，，03： | 1 |
| 19 | Control of LEDs to achieve light quality and intensity in tissue culture and micro - propagation studios 显示文摘 | JORDAN K A ONO E NORIKANE J | 2001 | Acta-Horticulturae2001，562，： | 1 |
| 20 | Interleukin-17 promotes angiogenesis and tumor growth显示文摘 | Numasaki M Fukushi J Ono M | 2003 | Blood2003，101，7： | 1 |
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