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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | The epithelial calcium channel,ECaC1:molecular details of a novel player in renal calcium handling显示文摘 | Müller D Hoenderop J G van Os C H | 2001 | Nephrol Dial Transplant2001，16，7： | 1 |
| 3 | A knowledge-based approach for control of two_level energy storage for wind energy systems显示文摘 | Abbey C Strunz K G'eza Jo'os | 2009 | IEEE Transactions on Energy Conversion2009，24，2： | 1 |
| 4 | Coupling of single-mode fibers to single-mode GRIN waveguides by butt-joining显示文摘 | Ríos S Srivastava R Gómez-Reino C | | 0，，56： | 1 |
| 5 | β2-glycoprotein I:a novel component of innate immu-nity显示文摘 | Agar C de Groot PG Mrgelin M Monk SD van Os G Levels JH | 2011 | Blood2011，117，25： | 1 |
| 6 | A Service Q uality M odel and Its M arketingIm p lic a tio n s 显示文摘 | G ron o os C | 1982 | E u ro p e a n Jo u rn a l o f M a rk e tin g1982，18，4： | 1 |
| 7 | The present and future of positive technologies显示文摘 | Botella C Riva G Gaggioli A Wiederhold B.K Alcaniz M & Ba(n)os R.M | | 0，，02： | 1 |
| 8 | Identification and genetic characterization of an ethylene-dependent polygalacturonase from apricot fruit显示文摘 | Leida C Ríos G Soriano JM | | 0，，01： | 1 |
| 9 | Effects of ozone treatm- ent on postharvest strawberry quality显示文摘 | PI~REZ A G SANZ C R~OS J J | 1999 | Journal of Agricultural and Food Chemistry1999，47，4： | 1 |
| 10 | Postinfectious bronchiolitis obliterans in children: Clinical and pulmonary function findings显示文摘 | Aguerre V Casta~os C Pena H G et aI | 2010 | Pediatr Pulmonol2010，45，12： | 1 |
| 11 | An unusual case of periarticular soft tissue finger swelling in an adolescent male:pachydermodacytly or pachyedermoperiostosis?显示文摘 | Rae A Zaphiroupou OS G C | 1994 | Br J Rheumatol1994，33，7： | 1 |
| 12 | Beta2-glycoprotein I can exist in 2 conformations: implications for our understanding of the antiphospholipid syndrome 显示文摘 | Agar C van Os G M Mfirgelin M | 2010 | Blood2010，116，8： | 1 |
| 13 | Severe cysticercal meningitis:clinical and imaging characteristics显示文摘 | Cárdenas G Jung H Ríos C | | 0，，： | 1 |
| 14 | Soil moisture, temper- ature, and drying influence on soybean emergence显示文摘 | Helms T C Deekard E I G~os R J | 1996 | Agronomy Journal1996，88，： | 1 |
| 15 | A glimpse of the mechanisms of ion homeostasis during salt stress显示文摘 | Mulet J M Ríos G Marquez J A de Larrinoa I Leube M Men-dizabal I Pascual-Ahuir A Proft M Ros R Montesinos C | 1999 | Experimental Botany1999，50，： | 1 |
| 16 | Induction of a protective antibody response to foot and mouth disease virus in mice following oral or parenteral immunization with alfalfa transgenic plants expressing the viralstrural protin VP1显示文摘 | WIGDOROVITZ A CARRILLO C DUS SANTOS M J TRONO K PERALTA A GMEZ M C ROS R D FRANZONE P M SADIR A M ESCRIBANO J M BORCA M V | 1999 | Virology1999，255，2： | 1 |
| 17 | T--cell dysfunction in HIV--1 infected patients with impaired recovery of CD4 cells de- spite suppression of viral replication 显示文摘 | ERIKSTRUP C KRONBORG G LOHSE N RYE OS GERSTOFT J ULLUM H | 2010 | AIDS2010，53，3： | 1 |
| 18 | A heuristic methodology to economic dispatch problem incorporating renewable power forecasting error and system reliability显示文摘 | Lujano-Rojas J M Osó rio G J Matias J C O | 2016 | Renewable Energy2016，87，3： | 1 |
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