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| 1 | 标准·方案·指南——2014年美国癌症学会最新宫颈癌筛查指南及筛查中存在的问题显示文摘美国癌症学会(ACS)每年都会发布有关癌症早期检测、癌症筛查率数据与趋势报告及相关问题的指南,并会持续关注可能需要在癌症筛查指南中做出相应改变与更新的医学科学文献中出现的新证据以及需要传达给临床工作者与公众的筛查相关信息。在制定新指南的过程中,ACS至少每5年对指南更新1次,如有重要新证据出现,则更新间隔时间会更短。本期就2014年ACS关于宫颈癌筛查的最新指南报道如下。 | Robert A Smith Deana Manassaram-Baptiste Durado Brooks Vilma Cokkinides Mary Doroshenk Debbie Saslow Richard C Wender Otis W Brawley 王静 | 2014 | 中国全科医学2014，17，27： | 16 |
| 2 | Revalence, awareness, treatment and control of hypertension among slum dwellers in Nairobi, Kenya 显示文摘 | vande Vijver SJ Oti SO Agyemang C | 2013 | J Hypertens2013，31，5： | 1 |
| 3 | Cannabinoids in pancreatic cancer: correlation with survival and pain显示文摘 | MICHALSKI C W OTI F E ERKAN M | 2008 | Inte J Can2008，122，4： | 1 |
| 4 | Prevalence of chronic pain, posttrau- rnatic stress disorder, and persistent post concussive symptoms in OIF/OEF veterans:Polytranma clinical triad显示文摘 | Lew HL Otis J D Tun C | 2009 | J Rehabil Res Dev2009，46，6： | 1 |
| 5 | Statistical inference from capture data on closed animal populations显示文摘 | Otis D L Burnham K P White G C | 1978 | Wildlife Monographs1978，62，： | 1 |
| 6 | Pluronic L-81 ameliorates diabetic symptoms in db/db mice through transcriptional regulation of microsomal triglyceride transfer protein显示文摘AIM: To test whether oral L-81 treatment could im-prove the condition of mice with diabetes and to investigate how L-81 regulates microsomal triglyceride transfer protein (MTP) activity in the liver. METHODS: Genetically diabetic (db/db) mice were fed on chow supplemented with or without L-81 for 4 wk. The body weight, plasma glucose level, plasma lipid profile, and adipocyte volume of the db/db mice were assessed after treatment. Toxicity of L-81 was also evaluated. To understand the molecular mecha-nism, HepG2 cells were treated with L-81 and the effects on apolipoprotein B (apoB) secretion and mRNA level of the MTP gene were assessed.RESULTS: Treatment of db/db mice with L-81 sig-nificantly reduced and nearly normalized their body weight, hyperphagia and polydipsia. L-81 also markedly decreased the fasting plasma glucose level, improved glucose tolerance, and attenuated the elevated levels of plasma cholesterol and triglyceride. At the effective dosage, little toxicity was observed. Treatment of HepG2 cells with L-81 not only inhibited apoB secretion, but also signif icantly decreased the mRNA level of the MTP gene. Similar to the action of insulin, L-81 exerted its effect on the MTP promoter. CONCLUSION: L-81 represents a promising candidate in the development of a selective insulin-mimetic mol-ecule and an anti-diabetic agent. | Wo-Shing Au Li-Wei Lu Sidney Tam Otis King Hung Ko Billy KC Chow Ming-Liang He Samuel S Ng Chung-Man Yeung Ching-Chiu Liu Hsiang-Fu Kung Marie C Lin | 2009 | World Journal of Gastroenterology2009，15，24： | 1 |
| 7 | HSP'27 as a mediator of confluence dependent resistance to cell death induced by anticancer drugs显示文摘 | GARRIDO C OTI'AVI P FROMENTIN A | 1997 | Cancer Res1997，57，13： | 1 |
| 8 | ACSM Posi- tion Stand on the female athlete triad显示文摘 | OTIS C L DRINKWATER B L JOHNSON M | 2007 | Med Sci Sports Ex- erc2007，29，： | 1 |
| 9 | Stress and birefringence measurements during the uniaxial elongation of polystyrene melts 显示文摘 | VENERUS D C ZHU S H OTI'INGER H C | 1999 | J Rheol1999，43，： | 1 |
| 10 | Ancestral chloroplast genome in Mesostigma viride reveals an early branch of green plant evolution 显示文摘 | LEMIEUX C OTIS C TURMEL M | 2000 | Nature2000，403，6770： | 1 |
| 11 | Structural stability and carbohydrate contents of an ultisol under different management systems显示文摘 | Adesodun J K Mbagwu J S C Oti N | 2001 | Soil and Tillage Research2001，60，34： | 1 |
| 12 | Loss of heterozygosity in P53,BRCA1,and estrogen receptor genes and correlation to expression of p53 protein in ovarian epithelial tumors of different cell types and biological behavior显示文摘 | Otis C N Krebs P A Quezado M M | 2000 | Hum Pathol2000，31，2： | 1 |
| 13 | The complete chloroplast DNA sequence of the green alga Nephroselmis Olivacea: Insights into the architecture of ancestral chloroplast genomes显示文摘 | Turmel M Otis C Lemieux C | 1999 | Proc Natl Acad Sci USA1999，96，10： | 1 |
| 14 | A study on solid-state drawn fibers of polyethylene by confocal Raman microspectrometry: evaluation of the orientation profiles of amorphous and crystalline phases across the fiber section显示文摘 | FAGNANO C ROSSI M PORTER R S OTI'ANI S | 2001 | Polymer2001，42，13： | 1 |
| 15 | Cannabinoids in pancre- atic cancer: correlation with survival and pain显示文摘 | Michalski C W Oti F E Erkan M | 2008 | Int J Cancer2008，122，4： | 1 |
| 16 | The chloroplast genome sequence of the green alga Leptosira terrestris: multiple losses of the inverted repeat and extensive genome rearrangements within the Trebouxiophyceae显示文摘 | DE CAMBIAIRE J C OTIS C LEMIEUX C TURMEL M | 2007 | BMC Genomics2007，8，： | 1 |
| 17 | Chloroplast DNA sequence of the green alga Oedogonium cardiacum (Chloro phyceae) :unique genome architecture, derived characters shared with the Chaetophorales and novel genes acquired through horizontal transfer显示文摘 | BROUARD J S OTIS C LEMIEUX C TURMEL M | 2008 | BMC Genomics2008，9，： | 1 |
| 18 | Structural stability and carbohydrate contents of an ultisol under different management systems显示文摘 | Adesodun J K Mbagwu J S C Oti N | 2001 | Soil and Tillage Research2001，60，34： | 1 |
| 19 | Novel dominant- negative prion protein mutants identified from a randomized li- brary显示文摘 | OTI' D TARABORRELLI C AGUZZI A | 2008 | Protein Engineering Design & Selection2008，21，10： | 1 |
| 20 | Aortic valve sclerosis as a marker of active atherosclerosis 显示文摘 | BRANCH K R O'BRIEN K D OTI'O C M | 2002 | Curr Cardiol Rep2002，4，2： | 1 |
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