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| 1 | Human umbilical cord mesenchymal stem cells for psoriasis:a phase 1/2a,single-arm study显示文摘Psoriasis is a common,chronic immune-mediated systemic disease that had no effective and durable treatment.Mesenchymal stem cells(MSCs)have immunomodulatory properties.Therefore,we performed a phase 1/2a,single-arm clinical trial to evaluate the safety and efficacy of human umbilical cord-derived MSCs(UMSCs)in the treatment of psoriasis and to preliminarily explore the possible mechanisms.Seventeen patients with psoriasis were enrolled and received UMsC infusions.Adverse events,laboratory parameters,PASl,and PGA were analyzed.We did not observe obvious side effects during the treatment and 6-month follow-up.A total of 47.1%(8/17)of the psoriasis patients had at least 40%improvement in the PASl score,and 17.6%(3/17)had no sign of disease or minimal disease based on the PGA score.And the efficiency was 25%(2/8)for males and 66.7%(6/9)for females.After UMSC transplantation(UMSCT),the frequencies of Tregs and CD4^(+)memory T cells were significantly increased,and the frequencies of T helper(Th)17 and CD4^(+)naive T cells were significantly decreased in peripheral blood(PB)of psoriasis patients.And all responders showed significant increases in Tregs and CD4^(+)memory T cells,and significant decreases in Th17 cells and serum IL-17 level after UMsCT.And baseline level of Tregs in responders were significantly lower than those in nonresponders.In conclusion,allogeneic UMSCT is safe and partially effective in psoriasis patients,and level of Tregs may be used as a potent biomarker to predict the clinical efficacy of UMSCT.Trial registration Clinical Trials NCT03765957. | Lamei Cheng Siqi Wang Cong Peng Xiao Zou Chao Yang Hua Mei Chuang Li Xian Su Na Xiao Qi Ouyang Mi Zhang Qiaolin Wang Yan Luo Minxue Shen Qun Qin Honglin Wang Wu Zhu Guangxiu Lu Ge Lin Yehong Kuang Xiang Chen | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 2 |
| 2 | Research on the decoupling control of contactless power transfer system with multiple Loads显示文摘 | YANG Minsheng WANG Yaonan OUYANG Honglin | 2007 | Journal of Hunan University2007，34，10： | 1 |
| 3 | AN EFFICIENT UE CLUSTER HEAD SELECTION ALGORITHM IN WIRELESS SENSOR NETWORKS AND CELLULAR NETWORKS显示文摘Wireless Sensor Networks (WSNs) have been applied in many different areas. Energy efficient algorithms and protocols have become one of the most challenging issues for WSN. Many researchers focused on developing energy efficient clustering algorithms for WSN, but less research has been concerned in the mobile User Equipment (UE) acting as a Cluster Head (CH) for data transmission between cellular networks and WSNs. In this paper, we propose a cellular-assisted UE CH selection algorithm for the WSN, which considers several parameters to choose the optimal UE gateway CH. We analyze the energy cost of data transmission from a sensor node to the next node or gateway and calculate the whole system energy cost for a WSN. Simulation results show that better system performance, in terms of system energy cost and WSNs life time, can be achieved by using interactive optimization with cellular networks. | Shan Lianhai Ouyang Yuling Yuan Zhi Fang Weidong Hu Honglin | 2013 | Journal of Electronics(China)2013，30，1： | 0 |
| 4 | Multi-valent mRNA vaccines against monkeypox enveloped or mature viron surface antigens demonstrate robust immune response and neutralizing activity显示文摘Monkeypox was declared a global health emergency by the World Health Organization,and as of March 2023,86,000 confirmed cases and 111 deaths across 110 countries have been reported.Its causal agent,monkeypox virus(MPV)belongs to a large family of double-stranded DNA viruses,Orthopoxviridae,that also includes vaccinia virus(VACV)and others.MPV produces two distinct forms of viral particles during its replication cycles:the enveloped viron(EV)that is released via exocytosis,and the mature viron(MV)that is discharged through lysis of host cells.This study was designed to develop multi-valent m RNA vaccines against monkeypox EV and MV surface proteins,and examine their efficacy and mechanism of action.Four m RNA vaccines were produced with different combinations of surface proteins from EV(A35R and B6R),MV(A29L,E8L,H3L and M1R),or EV and MV,and were administered in Balb/c mice to assess their immunogenicity potentials.A dynamic immune response was observed as soon as seven days after initial immunization,while a strong Ig G response to all immunogens was detected with ELISA after two vaccinations.The higher number of immunogens contributed to a more robust total Ig G response and correlating neutralizing activity against VACV,indicating the additive potential of each immunogen in generating immune response and nullifying VACV infection.Further,the m RNA vaccines elicited an antigen-specific CD4^(+)T cell response that is biased towards Th1.The m RNA vaccines with different combinations of EVand MV surface antigens protected a mouse model from a lethal dose VACV challenge,with the EV and MV antigens-combined vaccine offering the strongest protection.These findings provide insight into the protective mechanism of multi-valent m RNAvaccines against MPV,and also the foundation for further development of effective and safe m RNA vaccines for enhanced protection against monkeypox virus outbreak. | Niubing Zhang Xiang Cheng Yilong Zhu Ouyang Mo Huiqing Yu Liqi Zhu Juan Zhang Linlin Kuang Ying Gao Ruiyuan Cao Xiaozhen Liang Haikun Wang Honglin Li Song Li Wu Zhong Xuan Li Xiao Li Pei Hao | 2023 | Science China(Life Sciences)2023，66，10： | 0 |
| 5 | Explore the Energy Pearl of the Arctic Circle--Record on Arctic LNG2 project acquisition and construction显示文摘The Arctic LNG2 project is located in the Arctic Circle,west of the Gydan Peninsula,Russia.It has natural gas reserves of nearly 2 trillion cubic meters and gas condensate reserves of 99 million tons.Three LNG liquefaction trains at 6.6 mtpa each for the total LNG capacity of 19.8 mtpa as well as cumulative gas condensate production capacity of 1.6 mtpa are scheduled to be completed and put into operation between 2023 and 2026.Novatek(Russia’s largest independent natural gas producer)owns a 60%stake,and each of CNPC,CNOOC,and JAPAN Arctic LNG(“JAPAN Arctic”,a consortium of Mitsui and JOGMEC)owns a 10%stake in the project.The project is the world’s first LNG project using GBS and modular construction built offshore in the polar region。 | Xu Haixia Li Baoxin Qiao Yan Jing Lu Jin Fangfei Ouyang Liangchen Sun Rengjian Zhang Honglin | 2021 | China Oil & Gas2021，28，5： | 0 |
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