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| 1 | Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”显示文摘Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, S.aureus intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure. | Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan | 2019 | Bone Research2019，7，3： | 19 |
| 2 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 3 | C-reactive protein as an outcome predictor for maintenance hemodialysis patients显示文摘 | LOWRIE E G | 1998 | Kidney Int1998，54，： | 1 |
| 4 | Timed ammonia release for steers显示文摘 | Mizwicki K L Owens F N PolingK | 1980 | J Anita Sci1980，51，： | 1 |
| 5 | CBF10rthologs in Sour Cherry and Strawberry and The Heterologous Expression of CBFI in Strawberry显示文摘 | OWENS C L THOMASHOW M F HANCOCK J F | 2002 | J Am Soci Hort Sci2002，127，4： | 1 |
| 6 | Enhanced Selenium Tolerance and Accumulation in Transgenic Arabidopsis Expressing a Mouse Selenocysteine Lyase显示文摘 | Pilon M Owen J D Garifullina G F | 2003 | Plant Physiology2003，131，： | 1 |
| 7 | Insulin-like growth Factor- Ⅰ (IGF- Ⅰ ) and especially IGF- Ⅰ variants are anabolic in dexamethasone-treated rat显示文摘 | Tomas F M Knowles S E Owens P C | 1992 | Biochem J1992，282，： | 1 |
| 8 | Excitatory GA BA responses in embryonic and neonatal cortical slices demon strated by grarnicidin perforated- patch recordings and calei um imaging显示文摘 | Owens D F Boyce L H Davis M B | 1996 | J Neurosci1996，16，20： | 1 |
| 9 | Platelet-derived growth factor-BB and Ets-1 transcription factor negatively regulate transcription of multiple smooth muscle cell differentiation marker genes显示文摘 | Dandré F Owens G K | | 0，，06： | 1 |
| 10 | Understanding environmental influences on walking显示文摘 | Neville Owen Nancy Humpel Eva Leslie Adrian Bauman James F Sallis | 2004 | American Journal of Preventive Medicine2004，，1： | 1 |
| 11 | Spatial variability analysis of soil physical properties of alluvial soils 显示文摘 | IQBAL J THOMASSON J A JENKINS J N OWENS P R AND WHISLER F D | 2005 | Soil Science Society of America Journal2005，69，： | 1 |
| 12 | Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins显示文摘 | Huang H Sun F Owen D | 2007 | Proc Natl Acad Sci USA2007，104，14： | 1 |
| 13 | Mapping the sigma70 subunit contact sites on Escherichia coli RNA polymerase with a sigma70-conjugated chemical protease显示文摘 | Owens J T Miyake R Meares C F | 1998 | Proc Natl Aced Sci USA1998，95，： | 1 |
| 14 | A review of the physical and chemical properties of human semen and the formulation of a semen simulant显示文摘 | Owen D H Katz D F | 2005 | J Androl2005，26，4： | 1 |
| 15 | Myasthenia gravis in South Africans: racial differences in clinical manifestations 显示文摘 | Heckmann JM Owen EP Little F | 2007 | Neuromuscul Disord2007，17，： | 1 |
| 16 | Fundamentals of Anaerobic Digestion of Wastewater Sludge显示文摘 | PARKING F OWEN W F | 1986 | J Environ Eng1986，112，5： | 1 |
| 17 | Enhancement of Freezing Tolerance of Strawberry by Heterologous Expression of CBFI显示文摘 | OWENS C L LEZZONI A F HANCOCK J F | 2003 | ActaHort2003，，626： | 1 |
| 18 | Vitamin D3 supplementation of beef steers increases longissimus tenderness显示文摘 | Swanek S S Morgan J B Owens F N | 1999 | J Anim Sci1999，77，： | 1 |
| 19 | The relationship be- tween endogenous insulin-like growth factors and growth in pigs 显示文摘 | Owens F N Gatford K I Wahon P E | 1999 | J Anim Sci1999，77，： | 1 |
| 20 | Flaking corn: processing mechanics, quality standards, and impacts on energy availability and performance of feedlot cat- tle显示文摘 | ZINN R A OWENS F N WARE R A | 2002 | Journal of Animal Science2002，80，5： | 1 |
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