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| 1 | Time-course pattern of neuronal loss and gliosis in gerbil hippocampi following mild, severe, or lethal transient global cerebral ischemia显示文摘Transient ischemia in the whole brain leads to neuronal loss/death in vulnerable brain regions. The striatum, neocortex and hippocampus selectively loose specific neurons after transient ischemia. Just 5 minutes of transient ischemia can cause pyramidal neuronal death in the hippocampal cornu ammonis (CA) 1 field at 4 days after transient ischemia. In this study, we investigated the effects of 5-minute (mild), 15-minute (severe), and 20-minute (lethal) transient ischemia by bilateral common carotid artery occlusion (BCCAO) on behavioral change and neuronal death and gliosis (astrocytosis and microgliosis) in gerbil hippocampal subregions (CA1-3 region and dentate gyrus). We performed spontaneous motor activity test to evaluate gerbil locomotor activity, cresyl violet staining to detect cellular distribution, neuronal nuclei immunohistochemistry to detect neuronal distribution, and Fluoro-Jade B histofluorescence to evaluate neuronal death. We also conducted immunohistochemical staining for glial fibrillary acidic protein and ionized calcium-binding adapter molecule 1 (Ibal) to evaluate astrocytosis and microgliosis, respectively. Animals subjected to 20-minute BCCAO died in at least 2 days. BCCAO for 15 minutes led to pyramidal cell death in hippocampal CA1-3 region 2 days later and granule cell death in hippocampal de匚tate gyrus 5 days later. Similar results were not found in animals subjected to 5-minute BCCAO. Gliosis was much more rapidly and severely progressed in animals subjected to 15-minute BCCAO than in those subjected to 5- minute BCCAO. Our results indicate that neuronal loss in the hippocampal formation following transient ischemia is significantly different according to regions and severity of transient ischemia. The experimental protocol was approved by Institutional Animal Care and Use Committee (AICUC) of Kangwon National University (approval No. KW-180124-1) on May 22, 2018. | Tae-Kyeong Lee Hyunjung Kim Minah Song Jae-Chul Lee Joon Ha Park Ji Hyeon Ahn Go Eun Yang Hyeyoung Kim Taek Geun Ohk Myoung Cheol Shin Jun Hwi Cho Moo-Ho Won | 2019 | Neural Regeneration Research2019，14，8： | 3 |
| 2 | Antioxidant activities of tocopherols 显示文摘 | Ohk A Ka J Aria Y | 2001 | Polym Degrad Stab2001，72，2： | 1 |
| 3 | Different pattern of expression of nestin in the non-specific form of dysembryoplastic neuroepithelial tumors compared to the simple and complex forms显示文摘 | Chang Ohk Sung Yeon-Lim Suh | | 0，，： | 1 |
| 4 | rran-Stilbe-noids: potent and selective inhibitors for human cyto-chrome P450 1B1 显示文摘 | CHUN Y J LIM C OHK S O | 2011 | MedChemComm2011，2，5： | 1 |
| 5 | Stock index futures listing and structural change in time-varying volatility显示文摘 | Lee S B Ohk K Y | 1992 | Journal of Futures Markets1992，12，5： | 1 |
| 6 | Multiplex fiber optic biosensor for detection of Listeria monocytogenes,Escheriehia coli O157:H7 and Salmo- nella enterica from ready-to-eat meat samples显示文摘 | Ohk SH Bhunia AK | 2013 | Food Microbiol2013，33，2： | 1 |
| 7 | Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis 显示文摘 | ZHA J WEILER S OHK J | 2000 | Science2000，290，5497： | 1 |
| 8 | Antibody-aptamer func- tionalized fibre-optie biosensor for speeifie detection of Liste- ria monoeytogenes from food显示文摘 | OHK S H KOO O K SEN T | 2010 | Journal of Applied Mierobiol- ogy2010，109，3： | 1 |
| 9 | Pu-rification and properties of bacteriolytic enzymes from Bacillus licheniformis YS-1005against Streptococcus mu-tans显示文摘 | KIM SY OHK S H BAI DH | 1999 | Bioscience Biotechnology and Biochemistry1999，63，1： | 1 |
| 10 | Numerical simulation of sleeve repair welding of in-service gas pipelines 显示文摘 | Bang I W Son YP OhK H | 2002 | Welding Journal2002，81，12： | 1 |
| 11 | Stock and index futures listing and structure change in time-varying volatility显示文摘 | OHK K Y | 1992 | Journal of Futures Markets1992，12，5： | 1 |
| 12 | Formulation of rod-forming models and their application in spray forming显示文摘 | Seok H K Lee H C OhK H | 2000 | Metall Mater Trans A2000，31，5： | 1 |
| 13 | Does futures trading increase stock market volatility:theUS,Japan,the UK and Hong Kong显示文摘 | Lee S B Ohk K Y | 1992 | Reviews of Futures- Markets1992，11，5： | 1 |
| 14 | Stock Index Futures Listing and Structural Change In Time - Varying Volatility显示文摘 | Sang Bin Lee Ki Yool Ohk | 1992 | Journal of Futures Markets1992，12，5： | 1 |
| 15 | Stock index futures listing and structural change in time-varying volatility显示文摘 | Lee SB Ohk KY | 1992 | Futures Markets1992，12，： | 1 |
| 16 | Depthcodingusingaboundaryreconstructionfilterfor3Dvideosystem显示文摘 | OhKJ VetroA HoYS | 2011 | IEEETransactionsonCircuitsandSystemsforVideoTechnology2011，21，35： | 1 |
| 17 | Multiplex fiber optic biosensor for detection of Listeria monocytogenes, Escherichia coli O157 :H7 and Salmonella enterica from ready-to-eat meat samples显示文摘 | Ohk S H Bbunia A K | 2013 | Food Microbiol2013，33，2： | 1 |
| 18 | Multiplex fiber optic biosensor for detection of Listeria monocytogenes,Escherichia coli O157:H7 and Salmonella enterica from ready-to-eat meat samples显示文摘 | Ohk SH Bhunia AK | | 0，，02： | 1 |
| 19 | Antibody - aptamer functionalized fibre -optic biosensor for specific detection of Listeria monocytogenes from food 显示文摘 | Ohk S H Koo O K Sen T | 2010 | Journal of Applied Microbiology2010，109，3： | 1 |
| 20 | Human heart-type eytoplasmic fatty acid-binding protein(H-FABP)for the diagnosis of acute myocardial infarection Clinical evaluation of H-FABP in comparison with myoglobin and creatine kinase isoenzyme MB显示文摘 | Okamoto F Sohmiya K Ohk aru Y | | Clin Chem L0，，： | 1 |
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