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171篇 您的检索式：作者名="Ohmae"

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	题名	作者	年代	出处	被引量
1	NF-κB and ERK-signaling pathways contribute to the gene expression induced by cag PAI-positive-Helicobacter pylori infection显示文摘AIM: To elucidate the sequential gene expression profile in AGS cells co-cultured with wild-type Hellcobacter pylori (Hpylon) as a model of H pylori-infected gastric epithelium, and to further examine the contribution of cag-pathogenicity islands (cagPAI)-coding type Ⅳ secretion system and the two pathways, nuclear factor kappa B (NF-κB) and extracellular signal-regulated kinases (ERK) on wild-type H pylori-induced gene expression. METHODS: Gene expression profiles induced by H pylori were evaluated in AGS gastric epithelial cells using cDNA microarray, which were present in the 4 600 independent clones picked up from the human gastric tissue. We also analyzed the contribution of NF-κB and ERK signaling on H pylori-induced gene expression by using inhibitors of specific signal pathways. The isogenic mutant with disrupted capE (△cagE) was used to elucidate the role of capPAI-encoding type Ⅳ secretion system in the gene expression profile. RESULTS: According to the expression profile, the genes were classified into four clusters. Among them, the clusters characterized by continuous upregulation were most conspicuous, and it contained many signal transducer activity-associated genes. The role of cagPAI on cultured cells was also investigated using isogenic mutant cagE, which carries non-functional cagPAI. Then the upregulation of more than 80% of the induced genes (476/566) was found to depend on cagPAI. Signal transducer pathway through NF-κB or ERK are the major pathways which are known to be activated by cagPAI-positive H pylori. The role of these pathways in the whole signal activation by cagPAI- positive H pylori was analyzed. The specific inhibitors against NF-κB or ERK pathway blocked the activation of gene expression in 65% (367/566) or 76% (429/566) of the genes whose activation appealed to depend on cagPAI. CONCLUSION: These results suggest that more than half of the genes induced by cagPAI-positive H pylori depend on NF-κB and ERK signaling activation, and these pathways may play a role in the gene expression induced by host-bacterial interaction which may associate with H pylori-related gastro-duodenal diseases.	Wataru Shibata Yoshihiro Hirata Haruhiko Yoshida Motoyuki Otsuka Yujin Hoshida Keiji Ogura Shin Maeda Tomoya Ohmae Ayako Yanai Yuzo Mitsuno Naohiko Seki Takao Kawabe Masao Omata	2005	World Journal of Gastroenterology2005，11，39：	12
2	A clinical evaluation oftitanium mini-implants as anchors for orthodontic intrusion inthe beagle dogs显示文摘	Ohmae M Saito S Morohashi T	2001	Clin J Orthod2001，119，5：	1
3	Synergistic effect of hyperthermal atomic oxygen beam and vacuum ultraviolet radiation exposures on the mechanical deg- radation of high-modulus aramid fibers显示文摘	Ohmae N Ghosh L Fadhilah M H	2006	Polymer2006，47，19：	1
4	A study of the methamphetamine and 4-bromo - 2,5- dimethoxyphenethylamine (2C-B) in isolated rat hepatocytes 显示文摘	Kanamori T Tsujikawa K Ohmae Y	2005	Forensic Sci Int2005，148，：	1
5	MyD88 and TNF receptor-associated factor 6 are critical signal transducers in Helicobacter Dylori-infected human epithelial cells显示文摘	Hirata Y Ohmae T Shibata W	2006	J Immunol2006，176，：	1
6	A clinical and histological evaluation of titanium mini-implants as anchors for orthodontic intrusion in the beagle dog显示文摘	Ohmae M Saito S Morohashi T	2001	Am J Orthod Dentofac Orthop2001，119，5：	1
7	A clinical and histo: logical evaluation of titanium mini-implant as anchors for orthodontic intrusion in the beagle dog显示文摘	Ohmae M Saito S Morohashi T	2001	Am J Orthod Dentofacial Orthop2001，119，：	1
8	Endothelin - l levels in chronic congestive heart failure 显示文摘	Ohmae M	2011	Wien Klin Wochenschr2011，123，2324：	1
9	A clinical and histological evaluation of titanium mini-implants as anchors for orthodontic intrusion in the beagle dog 显示文摘	Ohmae M Saito S Morohashi T	2001	Am J Orthod Dentofacial Orthop2001，119，5：	1
10	A clinical and histologieal cvaluafion of titanium mini-implants as anchors for orthodontic intrusion in the beagle dog显示文摘	OHMAE M SAITO S MOROHASI T	2001	Am J Orthod Dentofac Orthop2001，119，5：	1
11	The Rise of Region State 显示文摘	Kenichi Ohmae	1993	Foreign Affairs Spring1993，，2：	1
12	The strategic triangle: A new perspective on business unit strategy 显示文摘	OHMAE K	1982	European Management Journal1982，1，1：	1
13	A clinical and histological evaluation of titanium mini-implants as anchors for orthodontic intrusion in the beagle dog显示文摘	Ohmae M Saito S Morohashi T	2001	Am J Orthod Dentofacial Orthop2001，119，5：	1
14	Endothelin-1 levels in chronic congestive heart failure 显示文摘	Ohmae M	2011	Wien Klin Woehenschr2011，123，2324：	1
15	Biological characteristics and control of intermediate snail host of Schistosoma japonicum 显示文摘	Ohmae H Iwanaga Y Nara T	2003	Parasitol Int2003，52，40：	1
16	Polymer synthesis and modification by enzymatic catalysis 显示文摘	Kobayashi S Ohmae M	2007	Macromoleeular Engineering2007，11，3：	1
17	A clinical and histological evaluation of titanium mini-implants as anchors for orthodontic intrusion in the beagle dog显示文摘	Ohmae M Saito S Morohashi T	2001	Am J Orthod Dentofacial Orthop2001，119，5：	1
18	Sitafloxacin resist- ance in Helicobacter pylori isolates and sitafloxacin- based triple therapy as a third-line regimen in japan显示文摘	Hirata Y Ohmae T Yanai A	2012	Int J Antimicrob Agents2012，39，4：	1
19	A clinical and histological evaluation of titanium mini-implants as anchors for orthodontic intrusion in the beagle dog显示文摘	Ohmae M Saito S Morohashi T	2001	Am J Orthod Dentofacial Orthop2001，119，5：	1
20	An Effective BECN/CRN Typed Deflection Routing for QoS Guaranteed Optical Burst Switching显示文摘	Hiroki T Ohmae K Young-Bok C	2003	IEEE Globecom2003，5，：	1

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