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| 1 | Synthesis and BK channel-opening activity of novel N-acylhydrazone derivatives from dehydroabietic acid显示文摘A series of hydrazone and N-acylhydrazone derivatives of dehydroabietic acid were synthesized and evaluated for BK channel-opening activities in an assay system of CHO-K1 cells expressing hBKa channels.The assay results indicated that the activities of the investigated compounds were influenced by the physicochemical properties of the substituent at hydrazone moiety. | Xia-Shi Lv Yong-Mei Cui He-Yun Wang Hai-Xia Lin Wei-Ya Ni Tomohiko Ohwada Katsutoshi Ido Kohei Sawada | 2013 | Chinese Chemical Letters2013，24，11： | 4 |
| 2 | Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer显示文摘AIM: To investigate the clinical significance of BMP and activin membrane-bound inhibitor (BAMBI) which is a pseudoreceptor of transforming growth factor-beta (TGF-β) type Ⅰreceptors and acts as a negative regulator of TGF-β signaling and expression aberrantly elevated in colorectal cancers (CRCs). We studied BAMBI expression in CRCs. METHODS: We studied BAMBI expression in 183 surgically resected CRCs by immunochemical and immunoblotting analyses using a generated monoclonal anti-BAMBI antibody. Commercially available anti-β-catenin and anti-p53 antibodies were also applied for immunochemical analyses as a comparison control.RESULTS: Immunohistochemical analysis revealed that BAMBI expression was observed in 148 (80.8%), and strong BAMBI expression was observed in 46% of the CRCs. Strong BAMBI expression was positively correlated with histological type, depth of invasion, lymph node metastases, and tumor node metastasis (TNM) stage (P < 0.05). Clear associations were found between BAMBI and β-catenin (P = 0.035) and p53 (P = 0.049) expression. In curatively resected CRC, 5-year recurrence-free survival was 51.9% (P = 0.037) for strong BAMBI expression compared to 79.8% for weak BAMBI expression. In the Cox’s multivariate analysis, lymph node metastases (RR 6.685; P < 0.001) and depth of invasion (RR 14.0; P = 0.013) were signifi cant indicators for recurrence, and strong BAMBI expression (RR 2.26; P = 0.057) tended to be signifi cant. CONCLUSION: BAMBI was linked to a potentially aggressive tumor phenotype and predicted tumor recurrence and cancer-related death in CRC. BAMBI expression might be applicable in the routine clinical setting of CRC. | Nozomi Togo Susumu Ohwada Shinji Sakurai Hiroyuki Toya Ichiro Sakamoto Tatsuya Yamada Tetsuhiro Nakano Ken Muroya Izumi Takeyoshi Takashi Nakajima Takashi Sekiya Yusuke Yamazumi Tsutomu Nakamura Tetsu Akiyama | 2008 | World Journal of Gastroenterology2008，14，31： | 3 |
| 3 | Development and evaluation of FSSG: frequency scale for the symptoms of GERD显示文摘 | Motoyasu Kusano Yasuyuki Shimoyama Sayaka Sugimoto Osamu Kawamura Masaki Maeda Keiko Minashi Shiko Kuribayashi Tatsuya Higuchi Hiroaki Zai Kyoko Ino Tsutomu Horikoshi Tadashi Sugiyama Munetoshi Toki Tsuneo Ohwada Masatomo Mori | 2004 | Journal of Gastroenterology2004，，9： | 2 |
| 4 | Effectiveness of treating menorrhagia using microwave endometrial ablation at a frequency of 2.45 GHz显示文摘BACKGROUND Microwave endometrial ablation(MEA)is a minimally invasive treatment for menorrhagia.It has been covered by the national insurance in Japan since April 2012,and its demand has been increasing as the importance of women’s health has advanced in society.AIM To examine the efficacy of MEA as a treatment option for menorrhagia.METHODS In this study,we retrospectively analyzed 76 patients who underwent MEA between January 2016 and March 2020 in our department.MEA was performed in the lithotomy position,under general anesthesia,and with transabdominal ultrasound guidance,including the entire endometrial circumference while confirming endometrial coagulation.The Microtaze AFM-712 and the Sounding Applicator CSA-40CBL-1006200C were used for MEA,and the endometrium was ablated using a Microtaze output of 70 W and coagulation energization time of 50 s per cycle.The visual analog scale(VAS)was used to evaluate menorrhagia,menstrual pain,and treatment satisfaction.Additionally,the hemoglobin(Hb)levels before and after MEA and associated complications were investigated.RESULTS The average age of the patients was 44.8±4.0 years.While 14 patients had functional menorrhagia,62 had organic menorrhagia,of whom 14 had endometrial polyps,40 had uterine fibroids,and 8 had adenomyosis.The VAS score before MEA and 3 and 6 mo after the procedure were 10,1.3±1.3,and 1.3±1.3,respectively,for menorrhagia and 10,1.3±1.8,and 1.3±1.8,respectively,for menstrual pain,both showing improvements(P<0.001).The MEA Hb level significantly improved from 9.2±4.2 g/dL before MEA to 13.4±1.2 g/dL after MEA(P=0.003).Treatment satisfaction was high,with a VAS score of 9.6±0.7.Endometritis was observed in one patient after surgery and was treated with antibiotics.CONCLUSION MEA is a safe and effective treatment for menorrhagia. | Toshiyuki Kakinuma Ayaka Kaneko Kaoru Kakinuma Yoshio Matsuda Kaoru Yanagida NobuhiroTakeshima Michitaka Ohwada | 2023 | World Journal of Clinical Cases2023，11，24： | 2 |
| 5 | Lymph node metastasis in stage I epithelial ovarian cancer 显示文摘 | SUZUKI M OHWADA M YAMADA T | 2000 | Gynecol Oncol2000，79，2： | 1 |
| 6 | Phase 1 study of combination chemotlerapy using irinotecan, and nedaplatin for advanced or recurrent cervical cancer 显示文摘 | MACHIDA S OHWADA M FUJIWARA H | 2003 | Oncology2003，65，2： | 1 |
| 7 | In situ vses situ pancreatic duct stents of duct-to-muco sapancreaticojejunostomy after pancresticoduodenectomy with billrothl-typereconst ruction显示文摘 | Ohwada S Tanahashi Y Ogawa T | 2002 | Arch Surg2002，137，11： | 1 |
| 8 | The pri- mary cilia of secretory cells in the human oviduct mucosa 显示文摘 | HAGIWARA H OHWADA N AOKI T | 2008 | Med Mol Morphol2008，41，4： | 1 |
| 9 | Pelvic lymphocysts following retroperitoneal lymphadenectomy:retroperitoneal partial 'no-closure'for ovarian and endometrial cancers显示文摘 | Suzuki M Ohwada M Sato I | | 0，，03： | 1 |
| 10 | Surgery for tumor thrombi in the right atrium and inferior vena cava of patients with recurrent hepatocellular carcinoma显示文摘 | OHWADA S TANAHASHI Y KAWASHIMA Y | 1994 | Hepatogastroenterology1994，41，： | 1 |
| 11 | Prognostic significance of DNA topoisomerase Ⅱ alpha expression in human hepatocellular carcinoma显示文摘 | Watanuki A Ohwada S Fukusato T | 2002 | Anticancer Res2002，22，2： | 1 |
| 12 | Plasma neuropeptides in patients undergoing lumbar discectomy 显示文摘 | Takeuchi H Kawaguehi S Ohwada O | 2007 | Spine2007，32，： | 1 |
| 13 | Decidualization of ovarian endometriosis during pregnancy mimicking malignancy: report of three cases with a literature review显示文摘 | Machida S Matsubara S Ohwada M | 2008 | Gynecol Obstet Invest2008，66，4： | 1 |
| 14 | Presence of tetrodotoxin and tetrodotoxin producing bacteria in freshwater sediments 显示文摘 | Do H K Hamasaki K Ohwada K | 1993 | Appl Enviro Microbiol1993，99，： | 1 |
| 15 | Numerical Analysis of the Plane Couette Flow of a Rarefied Gas on the Basis of the Linearized Boltzmann Equation for Hard-Sphere Molecules 显示文摘 | Sone Y Taka S Ohwada T | 1990 | European Journal of Mechanics B/ Fluids1990，9，： | 1 |
| 16 | Intramucosal pH and intestinal mucosal damage in ischemia-reperfusion injury显示文摘 | Kotaro Iwanami I. Takeyoshi Susumu Ohwada Junya Kobayashi Kiyoshi Kawata Koshi Matsumoto Yasuo Morishita | 1998 | Transplant International1998，，6： | 1 |
| 17 | Abnormal fragile histidine triad expression in advanced cervical cancer and evaluation of its utility as a prognostic factor显示文摘 | Machida S Ohwada M Saga Y | 2003 | Oncol2003，65，1： | 1 |
| 18 | New endoscopic treatmentfor chronic pancreatitis,using contrast media containing ulinastatinand prednisolone显示文摘 | Ohwada M Watanabe N Maeda M | 1997 | Gastroenterol1997，32，2： | 1 |
| 19 | GaAs Ultra-High-Frequency Dividers with Advanced SAINT FET's显示文摘 | Osafune K Enoki T Yamasaki K and Ohwada K | 1986 | IEEE Transactions on Microwave Theory and Techniques1986，34，12： | 1 |
| 20 | Integrating information visualization and retrieval for WWW information discovery显示文摘 | Hayato Ohwada Fumio Mizoguchi | 2003 | Theoretical Computer Sclence2003，，2： | 1 |
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