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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Effect of a retrograde-viewing device on adenoma detection rate during colonoscopy: the TERRACE study显示文摘 | Anke M. Leufkens Daniel C. DeMarco Amit Rastogi Paul A. Akerman Kassem Azzouzi Richard I. Rothstein Frank P. Vleggaar Alessandro Repici Giacomo Rando Patrick I. Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H. Deprez Brian P. Sau | 2011 | Gastrointestinal Endoscopy2011，，3： | 5 |
| 3 | Use of a plane jet for flow-induced noise reduction of tandem rods显示文摘Unsteady wake from upstream components of landing gear impinging on downstream components could be a strong noise source.The use of a plane jet is proposed to reduce this flow-induced noise.Tandem rods with different gap widths were utilized as the test body.Both acoustic and aerodynamic tests were conducted in order to validate this technique.Acoustic test results proved that overall noise emission from tandem rods could be lowered and tonal noise could be removed with use of the plane jet.However,when the plane jet was turned on,in some frequency range it could be the subsequent main contributor instead of tandem rods to total noise emission whilst in some frequency range rods could still be the main contributor.Moreover,aerodynamic tests fundamentally studied explanations for the noise reduction.Specifically,not only impinging speed to rods but speed and turbulence level to the top edge of the rear rod could be diminished by the upstream plane jet.Consequently,the vortex shedding induced by the rear rod was reduced,which was confirmed by the speed,Reynolds stress as well as the velocity fluctuation spectral measured in its wake.This study confirmed the potential use of a plane jet towards landing gear noise reduction. | 赵鲲 杨希祥 Patrick N Okolo 张为华 | 2016 | Chinese Physics B2016，25，6： | 4 |
| 4 | EUS-guided biliary drainage for patients with malignant biliary obstruction with an indwelling duodenal stent (with videos)显示文摘 | Mouen A. Khashab Larissa L. Fujii Todd H. Baron Marcia Irene Canto Christopher J. Gostout Bret T. Petersen Patrick I. Okolo Mark D. Topazian Michael J. Levy | 2012 | Gastrointestinal Endoscopy2012，，1： | 2 |
| 5 | Where have all the Helicobacter gone? Etiologic factors in patients with duodenal ulcers presenting to a University Hospital显示文摘 | Gislason GT Emu B Okolo Ⅲ P Pasricha PJ Kalloo AM | | 0，，： | 1 |
| 6 | Fibrods in pregnancy:common but poorly understood显示文摘 | Cooper NP Okolo S | 2005 | Obstet Gynecol Surv2005，60，2： | 1 |
| 7 | The Chemical Composition and Some Physical Properties of a Water-soluble Gum from Prosopis Africana Seeds显示文摘 | Aehi O K Okolo N I | 2004 | Ira J Food Sci Technol2004，39，4： | 1 |
| 8 | Nonalcoholico steatohepatitisand fatty liver显示文摘 | Okolo P Diehl A M | 1998 | Semin Liver Dis1998，19，2： | 1 |
| 9 | Fibrods in pregnancy common but poorly understood 显示文摘 | COOPER N P OKOLO S | 2005 | Obstetrical & Gynecological Survey2005，60，2： | 1 |
| 10 | Fibrods in pregnancy:common but poorly understood 显示文摘 | Cooper NP Okolo S | 2005 | Obstet Gynecol Surv2005，60，： | 1 |
| 11 | Mid-gut stents显示文摘 | Faming Zhang Stuart K. Amateau Mouen A. Khashab Patrick I. Okolo | 2012 | Current Opinion in Gastroenterology2012，，5： | 1 |
| 12 | The spiral enteroscopy training initiative: results of a prospective study evaluating the Discovery SB overtube device during small bowel enteroscopy (with video)显示文摘 | J. Buscaglia K. Dunbar P. Okolo J. Judah P. Akerman D. Cantero P. Draganov | 2009 | Endoscopy2009，，03： | 1 |
| 13 | Incidence, aetiology and epidemiology of uterine fibroids 显示文摘 | Okolo S | 2008 | Best Pract Res Clin Obstet Gynecol2008，22，4： | 1 |
| 14 | Vaccine induced rabies infection in rural dogs in Anambra State显示文摘 | Okolo M I | 1989 | Nigeria Microbios1989，57，： | 1 |
| 15 | Fibroids in pregnancy-common but poorly understood 显示文摘 | Cooper NP Okolo S | 2005 | Obstet Gynecol Surv2005，60，2： | 1 |
| 16 | Production of raw starch digest- ing amylase by Aspergillus niger grown of native starch sources显示文摘 | OKOLO B N EZEOGU L I MBA C N | 1995 | I Sei Food Agr1995，69，1： | 1 |
| 17 | Time of passage of first stools (meconium) and serum levels of calcium and magnesium in Nigerian neonates (African neonates)显示文摘 | Omoigberale AI Okolo AA | 2009 | Niger J Clin Pract2009，12，1： | 1 |
| 18 | Incidence,aetiology and epidemiology of uterine fibroids显示文摘 | Okolo S | | 0，，： | 1 |
| 19 | What are the long-termresults of endoscopic pancreatic sphincterotomy? 显示文摘 | Okolo PI Pasricha PJ Kalloo AN | 2000 | Gas- trointest Endose2000，52，： | 1 |
| 20 | Fibrods in pregnancy-common but poorly understood显示文摘 | Cooper NP Okolo S | 2005 | Obstet Gynecol Stow2005，60，： | 1 |
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