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2篇 您的检索式:作者名="Olaf Bergmann"
    题名 作者 年代 出处 被引量
1Dynamics of Hippocampal Neurogenesis in Adult Humans显示文摘Kirsty L. Spalding Olaf Bergmann Kanar Alkass Samuel Bernard Mehran Salehpour Hagen B. Huttner Emil Bostr?m Isabelle Westerlund Céline Vial Bruce A. Buchholz G?ran Possnert Deborah C. Mash Henrik Druid Jonas Frisén 2013Cell2013,,6:1
2Printed elastic membranes for multimodal pacing and recording of human stem-cell-derived cardiomyocytes显示文摘Bioelectronic interfaces employing arrays of sensors and bioactuators are promising tools for the study,repair and engineering of cardiac tissues.They are typically constructed from rigid and brittle materials processed in a cleanroom environment.An outstanding technological challenge is the integration of soft materials enabling a closer match to the mechanical properties of biological cells and tissues.Here we present an algorithm for direct writing of elastic membranes with embedded electrodes,optical waveguides and microfluidics using a commercial 3D printing system and a palette of silicone elastomers.As proof of principle,we demonstrate interfacing of cardiomyocytes derived from human induced pluripotent stem cells(hiPSCs),which are engineered to express Channelrhodopsin-2.We demonstrate electrical recording of cardiomyocyte field potentials and their concomitant modulation by optical and pharmacological stimulation delivered via the membrane.Our work contributes a simple prototyping strategy with potential applications in organ-on-chip or implantable systems that are multi-modal and mechanically soft.Markos Athanasiadis Dzmitry Afanasenkau Wouter Derks Christoph Tondera Francesca Murganti Volker Busskamp Olaf Bergmann Ivan R.Minev 2020npj Flexible Electronics2020,4,1:0
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