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| 1 | Quality of life:A critical outcome for all surgical treatmentsof gastric cancer显示文摘Surgery represents the main curative therapeutic modality for gastric cancer, and it is occasionally considered for palliation as well as prophylaxis. Most frequently, surgical outcomes are conveyed in terms of oncological outcomes such as recurrence and survival.However, quality of life(Qo L) is also important and should be considered when making treatment decisions- including the extent of and approach to surgery. Measurement of Qo L usually involves the application of questionnaires. While there are multiple Qo L questionnaires validated for use in oncology patients, there are very few that have been validated for use in those with gastric cancer. In this review, we discuss and compare the current status of Qo L questionnaires in gastric cancer. More importantly, the impact of surgery for treatment, palliation and prophylaxis of gastric cancer on Qo L will be described. These data should inform the surgeon on the optimal approach to treating gastric cancer, taking into account oncological outcomes. Knowledge gaps are also identified, providing a roadmap for future studies. | Michael D McCall Peter J Graham Oliver F Bathe | 2016 | World Journal of Gastroenterology2016，22，3： | 7 |
| 2 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 3 | Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study显示文摘 | Olivier Rixe Ronald M Bukowski M Dror Michaelson George Wilding Gary R Hudes Oliver Bolte Robert J Motzer Paul Bycott Katherine F Liau James Freddo Peter C Trask Sinil Kim Brian I Rini | 2007 | Lancet Oncology2007，，： | 2 |
| 4 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 5 | Induction of hair growth in ear wounds by cultured dermal papilla cells显示文摘 | JAHODA C A REYNOLDS A J OLIVER H F | 1993 | J Invest Dermatol1993，101，4： | 1 |
| 6 | Effect of feed deprivation and lairage time on carcass and meat quality traits on pigs under minimal stressful conditions显示文摘 | Panella-Riera N Gispert M Gil M Soler J Tibau J Oliver M A Velarde A Fàbrega E | | 0，，01： | 1 |
| 7 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 8 | Entry into and resuscitation from the viable but nonculturable state by Vibrio vulnificus in an estuarine environment显示文摘 | Oliver J D Hite F McDougald D | 1995 | Appl Environ Microbiol1995，61，7： | 1 |
| 9 | The deformation behavior of ceramic crystals subjected to very low load nanoindentations显示文摘 | PAGE T F OLIVER W C MCHARGUE C J | 1992 | Journal of Materials Research1992，7，2： | 1 |
| 10 | Peritoneal macrophages and infertility:the association between cell number and pelvic pathology显示文摘 | Olive D L Weinberg J B Haney A F | 1985 | Fertil Steril1985，44，6： | 1 |
| 11 | Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole ST Brosch R Parkhill J Garnier T Churcher C Harris D Gordon SV Eiglmeier K Gas S Barry CE Tekaia F Badcock K Basham D Brown D Chillingworth T Connor R Davies R Devlin K Feltwell T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Krogh A Mclean J Moule S Murphy L Oliver K Osborne J Quail MA Rajandream MA Rogers J Rutter S Seeger K Skelton J Squares R Squares S Sulston JE Taylor K Whitehead S Barrell BG | 1998 | Nature1998，393，6685： | 1 |
| 12 | Marginal zone and B1 B cells unite in the early response against t-independent blood-borne particulate antigens 显示文摘 | MARTIN F OLIVER A M KEARNEY J F | 2001 | Immunity2001，14，5： | 1 |
| 13 | Interaction of the thiol-dependent Reductase ERp57 with nasent glycoproteins 显示文摘 | van der Wal F J Bulleid N J | 1997 | Science1997，275，： | 1 |
| 14 | Densification of A1 powder and A1-Cu matrix composite (reinforced with 15 % Saffli short fibres) during axial cold compaction 显示文摘 | MORENO M F GONZ)tLEZ OLIVER C J R | 2011 | Powder Technology2011，206，： | 1 |
| 15 | Simulaneous detection and quantification of amphetamines,diazepam and its metabolites,cocaine and its metabolites,and opiates in hair by LC-ESI-MS-MS using a single extraction method显示文摘 | Miller E I Wylie F M Oliver J S | 2008 | Journal of Analytical Toxicology2008，32，： | 1 |
| 16 | T helper 1 and T helper 2 cells are pathogenic in an antigen specific model of colitis 显示文摘 | IQBAL N OLIVER J R WAGNER F H | 2002 | J Exp Med2002，195，1： | 1 |
| 17 | Trans-species hair growth induction by human hair follicle dermal papillae 显示文摘 | Jahoda C A Oliver R F Reynolds A J | 2001 | Exp Dermatol2001，10，4： | 1 |
| 18 | Allelopathic potential of wheat (Triticum aestivum) straw on selected weed species显示文摘 | Steinsiek J W Oliver L R Collins F C | 1982 | Weed Science1982，30，5： | 1 |
| 19 | Relationships between Asphah Rut Resistance and Binder Rheological Properties显示文摘 | Tredrea P F | 1998 | Journal of the Association of Asphalt Paving Technologists1998，67，1： | 1 |
| 20 | Inertial Navigation System Aided by GPS and Selective Frequency Contents of Vector Measurements显示文摘 | Oliv eira P | 2001 | IEEE position location and navigation symposium2001，，4： | 1 |
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