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| 1 | NAT2*6A, a haplotype of the N-acetyltransferase 2 gene, is an important biomarker for risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis显示文摘AIM: To investigate an association between N -acetyltransferase 2 (NAT2 )-haplotypes/diplotypes and adverse effects in Japanese pulmonary tuberculosis patients. METHODS: We studied 100 patients with pulmonary TB treated with anti-TB drugs including INH. The frequencies and distributions of single nucleotide polymorphisms, haplotypes, and diplotypes of NAT2 were determined by the PCR-restriction fragment length polymorphism method, and the results were compared between TB patients with and without adverse effect, using multivariate logistic regression analysis.RESULTS: Statistical analysis revealed that the frequency of a variant haplotype, NAT2*6A , was signifi cantly increased in TB patients with hepatotoxicity, compared with those without hepatotoxicity [P = 0.001, odds ratio (OR) = 3.535]. By contrast, the frequency of a wild-type (major) haplotype, 'NAT2*4', was signif icantly lower in TB patients with hepatotoxicity than those without hepatotoxicity (P < 0.001, OR = 0.265). There was no association between NAT2-haplotypes and skin rash or eosinophilia. CONCLUSION: The present study shows that NAT2 is one of the determinants of anti-TB drug-induced hepatotoxicity. Moreover, the haplotypes, NAT2*4 and NAT2*6A, are useful new biomarkers for predicting anti- TB drug-induced hepatotoxicity. | Norihide Higuchi Naoko Tahara Katsunori Yanagihara Kiyoyasu Fukushima Naofumi Suyama Yuichi Inoue Yoshitsugu Miyazaki Tsutomu Kobayashi Koh-ichiro Yoshiura Norio Niikawa, Chun-Yang Wen, Hajime Isomoto,Saburou Shikuwa, Katsuhisa Omagari, Yohei Mizuta, Shigeru Kohno, Kazuhiro Tsukamoto Norio Niikawa Chun-Yang Wen Hajime Isomoto Saburou Shikuwa Katsuhisa Omagari Yohei Mizuta Shigeru Kohno Kazuhiro Tsukamoto | 2007 | World Journal of Gastroenterology2007，13，45： | 21 |
| 2 | Enzyme inhibition assay for pyruvate dehydrogenase complex: Clinical utility for the diagnosis of primary biliary cirrhosis显示文摘Primary biliary cirrhosis (PBC) is usually diagnosed by the presence of characteristic histopathological features of the liver and/or antimitochondrial antibodies (AMA) in the serum traditionally detected by immunofluorescence. Recently, new and more accurate serological assays for the detection of AMA, such as enzyme-linked immunosorbent assay (ELISA), immunoblotting, and enzyme inhibition assay, have been developed. Of these, the enzyme inhibition assay for the detection of anti-pyruvate dehydrogenase complex (PDC) antibodies offers certain advantages such as objectivity, rapidity, simplicity, and low cost. Since this assay has almost 100% specificity, it may have particular applicability in screening the at-risk segment of the population in developing countries. Moreover, this assay could be also used for monitoring the disease course in PBC. Almost all sera of PBC-suspected patients can be confirmed for PBC or non-PBC by the combination results of immunoblotting and enzyme inhibition assay without histopathological examination. For the development of a 'complete' or 'gold standard' diagnostic assay for PBC, similar assays of the enzyme inhibition for anti-2-oxoglutarate dehydrogenase complex (OGDC) and anti-branched chain oxo-acid dehydrogenase complex (BCOADC) antibodies will be needed in future. | Katsuhisa Omagari Hiroaki Hazama Shigeru Kohno | 2005 | World Journal of Gastroenterology2005，11，43： | 5 |
| 3 | Changes in titers of antimitochondrial and antinuclear antibodies during the course of primary biliary cirrhosis显示文摘 | Masuda J Omagari K Matsuo I | | 0，，： | 2 |
| 4 | Effects of a Long-Term High-Fat Diet and Switching from a High-Fat to Low-Fat,Standard Diet on Hepatic Fat Accumulation in Sprague-Dawley Rats显示文摘 | OMAGARI K KATO S TSUNEYAMA K | 2008 | Digestive Diseases and Sciences2008，53，： | 1 |
| 5 | Changes in titers of antimitoehondrial and antinuelear antibodies during the course of primary biliary cirrhosis显示文摘 | Masuda J Omagari K Matsuo I | 2001 | J Gastroenterol Hepatol2001，16，2： | 1 |
| 6 | Fatry liver in nonalcoholic non-o- verweight Japanese adults,incidence and clinical characteristics显示文摘 | Omagari K Kadokaua Y Masuda J | 2002 | JGe- stroenterol epatol2002，17，5： | 1 |
| 7 | Gamma knife radiosurgery for simultaneous multiple metastatic brain tumors显示文摘 | Suzuki S Omagari J Nishio S | 2000 | J Neurosurg2000，93，： | 1 |
| 8 | Primary non-Hodgkin Lymphoma of the sinonasal cavities: correlation of CT evaluation with clinial outcome显示文摘 | Nakamura K Uehara S Omagari J | 1997 | Radiology1997，204，： | 1 |
| 9 | Primary non-Hodgkin lymphoma of the sinonasal cavities:correlation of CT evaluation with clinical outcomes显示文摘 | Nakamura K Uehara S Omagari J | 1997 | Radiology1997，204，： | 1 |
| 10 | Fatty liver in non-alcoholic non-overweight Japanese adults:incidence and clinical characteristics显示文摘 | Omagari K Kadokawa Y Masuda J | 2002 | J Gastroenterol Hepatol2002，17，10： | 1 |
| 11 | Fatty liver in non--alcoholicnon-overweight Japanese adults: incidence and clinical characteristics显示文摘 | Omagari K kadokawa Y Masuda | 2002 | J Gastroenterol Hepatol2002，17，： | 1 |
| 12 | Flare-up ofautoimmunehepatitisafter delivery in a patient with primary hiliarycirrhosis: postpartum overlapsyndrome of primary biliary cirrhosis and autoimmune hepatitis显示文摘 | Ohba K Omagari K Kusakari C | 2005 | Dig Dis Sci2005，50，1： | 1 |
| 13 | Clinical features of 89 patients with autoimmune hepatitis in Nagasaki prefecture, Japan显示文摘 | Omagari K Kinoshita H Kato Y | 1999 | J Gastroenterol1999，34，2： | 1 |
| 14 | Primary non-Hodg -kin's lymphoma of the maxillary sinus显示文摘 | Nakamura K Uehara S Omagari J | 1997 | Am J Clin Oncol1997，20，3： | 1 |
| 15 | Changes in titers of antimitochondrial and antinuclear antibodies during the course of primary biliary cirrhosis显示文摘 | Masuda J Omagari K Matsuo I | 2001 | J Gastroenterol Hep-atol2001，16，2： | 1 |
| 16 | Fatty liver in non-alcoholic non-overweight Japanese adults : incidence and clinical characteristics 显示文摘 | Omagari K Kadokawa Y Masuda J etal | 2002 | Gastroenterol Hepatol2002，17，5： | 1 |
| 17 | Fatty liver in non-alco-hotic non-overweight Japanese adults: incidence and clinical characteristics 显示文摘 | Omagari K Kadokawa Y Masuda J et at | 2002 | J Gastroenterot Hepatot2002，17，10： | 1 |
| 18 | Evaluation of newly developed ELISA using MESACUP-2 test mitochondrial M2 kit for the diagnosis of primary biliary cirrhosis显示文摘 | Kadokawa Y Omagari K Hazama H | 2003 | Clin Biochem2003，36，3： | 1 |
| 19 | Fatty liver in non - aleoholie non - overweight Japanese adults : ineidenee and clinical eharaeteristies 显示文摘 | Omagari K Kadokawa Y Masuda J | 2002 | J Gastroenterol Hepatol2002，17，10： | 1 |
| 20 | A possible mouse model for spontaneous cholangitis:serological and histological characteristics of MRL/lpr mice显示文摘 | Ohba K Omagari K Murase K | | 0，，03： | 1 |
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