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| 1 | Targeting the Wnt Signaling Pathway in Liver Fibrosis for Drug Options:An Update显示文摘morbidity and mortality for healthcare systems worldwide.It imparts an enormous economic burden to societies,making continuous research and informational updates about its pathogenesis and treatment crucial.This review′s focus is on the current knowledge about the Wnt signaling path-way,serving as an important pathway in liver fibrosis development and activation of hepatic stellate cells(HSCs).Two types of Wnt pathways are distinguished,namely the ß-catenin-dependent canonical and non-canonical Ca^(2+) or planar cell polarity(PCP)-dependent pathway.The dynamic balance of physiologically healthy liver and hepatocytes is disturbed by repeated liver injuries.Activation of theß-catenin Wnt pathway prevents the regeneration of hepatocytes by the replacement of extracellular matrix(ECM),leading to the appearance of scar tissue and the formation of regenerated nodular hepatocytes,lacking the original function of healthy hepatocytes.Therefore,liver function is reduced due to the severely advanced disease.Selective inhibition ofß-catenin inhibits inflammatory processes(since chemokines and pro-inflammatory cytokines are produced during Wnt activation),reduces growth of activated HSCs and reduces collagen synthesis and angiogenesis,thereby reducing the progression of liver fibrosis in vivo.While the canonical Wnt pathway is usually inactive in a physiologically healthy liver,it shows activity during cell regeneration or renewal and in certain pathophysiological conditions,such as liver diseases and cancer.Targeted blocking of some of the basic components of the Wnt path-way is a therapeutic approach.These include the frizzled transmembrane receptor(Fz)receptors using the secreted frizzled-related protein family(sFRP),Fz-coreceptors low-density LRP 5/6 through dickkopf-related protein 1(DKK1)or niclosamide,glycogen kinase-3 beta(GSK-3β)using SB-216763,cyclic-AMP response element-binding protein(CBP)using PRI-724 and ICG-001,the lymphoid enhancer binding factor(LEF)/T cell-specific transcription factor(TCF)system as well as Wnt inhibitory factor 1(WIF1)and miR-17-5p using pinostilbene hydrate(PSH).Significant progress has been made in inhibiting Wnt and thus stopping the progression of liver fibrosis by diminishing key components for its action.Comprehending the role of the Wnt signaling pathway in liver fibrosis may lead to discovery of novel targets in liver fibrosis therapeutic strategies’development. | Kristina Duspara Kristina Bojanic Josipa Ivanusic Pejic Lucija Kuna Tea Omanovic Kolaric Vjera Nincevic Robert Smolic Aleksandar Vcev Marija Glasnovic Ines Bilic Curcic Martina Smolic | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 2 |
| 2 | Interaction of 12-aminododecanoic acid with a carbon steel surface: Towards the development of ‘green’ corrosion inhibitors显示文摘 | Saad Ghareba Sasha Omanovic | 2010 | Corrosion Science2010，，6： | 1 |
| 3 | Interaction of 12-aminodode- canoic Acid with a Carbon Steel Surface:Towards the Devel- opment of ' Green' Corrosion lnhibitors 显示文摘 | GHAREBA S OMANOVIC S | 2010 | Corrosion Sci- ence2010，52，6： | 1 |
| 4 | Characterization ofNi, NiMo, NiW and NiFe electroactive coatings as electro cata- lysts for hydrogen evolution in an acidic medium 显示文摘 | NAVARRO F E CHONG Z W OMANOVIC S | 2005 | Journal of Molecular Catalysis A: Chemical2005，226，： | 1 |
| 5 | Hydrogen evolution on nickel incorporated in three-dimensional conducting polymer layers显示文摘 | Fiores E N Omanovic S | 2005 | Journal of Molecular Catalysis A: Chemical2005，242，： | 1 |
| 6 | Electrochemical studies of the assorption behavior of serum proteins on titanium 显示文摘 | Douglas R Jackson Sasha Omanovic Sharon G Roscoe | 2000 | Langmiur2000，16，： | 1 |
| 7 | Interaction of 12- aminodode- canoic acid with a carbon steel surface: Towards the de- velopment of green corrosion inhibitors 显示文摘 | Ghareba S Omanovic S | 2010 | Corrosion Science2010，52，6： | 1 |
| 8 | Characterization of Ni,NiMo,NiW and NiFe electroactive coatings as electrocatalysts for hydrogen evolution in an acidic medium显示文摘 | Navarro-Flores E Chong Z Omanovic S | 2005 | J Mol Catal A:Chem2005，226，2： | 1 |
| 9 | Effect of lineleate on electrochemical behavior of stainless steel in phosphate buffer 显示文摘 | Omanovic S Roscoe S G | 2000 | Corrosion2000，56，6： | 1 |
| 10 | Interaction of 12-aminododecanoic acid with a carbon steel surface:Towards the development of green corrosion inhibitors显示文摘 | GHAREBA S OMANOVIC S | | 0，，6： | 1 |
| 11 | 12-Aminododecanoic acid as a corrosion inhibitor for carbon steel 显示文摘 | GHAREBA S OMANOVIC S | 2011 | Electrochimica Acta2011，56，11： | 1 |
| 12 | The automatic ASV measurements of reversible electrode reactions显示文摘 | Dario Omanovic Marko Branica Pseudopolarography of trace metals:Part Ⅰ | 2003 | Journal of Electroanalytical Chemistry2003，543，1： | 1 |
| 13 | Characterization of Ni,NiMo,NiW and NiFe electroactive coatings as electrocatalysts for hydrogen evolution in an acidic medium显示文摘 | NAVARRO-FLORES E CHONG Z W OMANOVIC S S | 2005 | Journal of Molecular Catalysis A:Chemical2005，226，： | 1 |
| 14 | Electrochemical studies of the adsorption behavior of bovine serum albumin on stainless steel显示文摘 | Omanovic S Roscoe S G | | 0，，： | 1 |
| 15 | Interaction of 12-aminododecanoic acid with a carbon steel surface:Towards the development of 'green'corrosion inhibitors显示文摘 | GHAREBA S OMANOVIC S | | 0，，： | 1 |
| 16 | Characterization of Ni, NiMo, NiW and NiFe electroactive coatings as electrocatalysts for hydrogen evolution in an acidic medium 显示文摘 | Navarro-Flores E Chong Z Omanovic S | 2005 | Journal of Molecular Catalysis A : Chemical2005，226，： | 1 |
| 17 | 显示文摘 | ALI I SOOMRO B OMANOVIC S | 2011 | Electrochem Commun2011，13，： | 1 |
| 18 | Distribution and chemical speciation of arsenic and heavy metals in highly contami- nated waters used for health care purpose (Srebrenica, Bosnia and Herzegovina) 显示文摘 | Lenoble V Omanovic D Gamier G | 2013 | Science of the Total Environment2013，443，3： | 1 |
| 19 | 12-Aminododecanoic acid as a corrosion inhibitor for carbon steel显示文摘 | GHAREBA S OMANOVIC S | 2011 | Electrochimica Acta2011，56，11： | 1 |
| 20 | Characterization of Ni, NiMo, NiW and NiFe electroactive coatings as electrocatalysts for hydrogen evolution in an acidic medium 显示文摘 | NAVVARO-FLORES E CHONG Z OMANOVIC S | 2005 | Journal of Molecular Catalysts A: Chemical2005，226，2： | 1 |
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