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| 1 | Hypofractionated stereotactic rad iotherapy alone without whole-brain irradiation for patien ts with solitary and oligo brain metastasis using noninvasive fixation of the skull显示文摘To evaluate the efficacy and toxicity of hypofractionated stereotactic radiotherapy(HSRT)using noninvasive fixation of the sk ull on solitary or oligo brain metastatic p atients as an alternative to stereotactic radiosurgery(SRS)using invasive fixation.The subjects were 87patients who had 4or fewer brain meta stases(50solitary,37oligometastases).Treatment was conducted on 159meta stases by using a linac-based stereotactic system.T he median isocentric dose was 35Gy in4fractions.Whole-brain irradiati on was not applied as an initial treatment.For the salvage treatmen t of metachronous brain metastases,repeat HSRT or whole-brain irradiation was applied.The actuarial1-year local tumor control rate was 81%.Treatment-related complicatio ns were observed in 4patients in the e arly period(<3months)and in 2patients in the late period.T he median survival period was 8.7mon ths.Metachronous brain metastases occurred in 30patients,and none of the 18patients who were eligible for salvage HSRT refused to re ceive it again.Hypofractionated stereotactic radiotherapy achieved tumor control and survival equivalent to those of SRS reported i n the literature.The results suggested that HSRT could be an alternative for solitary or oligo br ain metastatic patients with less to xicity and less invasiveness compared to | Aoyama H Shirato H Onimaru R Kagei K Ikeda J Ishii N Sawamura Y Miyasaka K | 2003 | 癌症2003，22，7： | 12 |
| 2 | Combination with low-dose gemcitabine and hTERT-promoter-dependent condi- tionally replicative adenovirus enhances cytotoxicity through their crosstalk mechanisms in pancreatic cancer显示文摘 | Onimaru M Ohuchida K Nagai E | 2010 | Cancer Lett2010，294，2： | 1 |
| 3 | Respiratory network function in the isolated brainstem-spinal cord of newborn rats显示文摘 | Ballanyi K Onimaru H Homma I | 1999 | Prog Neurobiol1999，59，9： | 1 |
| 4 | Sp1decoy transfected to carcinoma cells suppresses the expression of vascular endothelial growth factor,transforming growth factor beta1,and tissue factor and also cell growth and invasion activities显示文摘 | Ishibashi H Nakagawa K Onimaru M | 2000 | Cancer Res2000，60，： | 1 |
| 5 | hTERT- promoter-dependent oncolytic adenovirus enhances the transduction and therapeutic efficacy of replicationdefective adenovirus vectors in pancreatic cancer cells 显示文摘 | Onimaru M Ohuchida K Mizumoto K | 2010 | Cancer Sci2010，101，3： | 1 |
| 6 | Steep dose-response relationship for stage I non-small-cell lung cancer using hypo- fractionated high-dose irradiation by real-time tumor-tracking radiotherapy显示文摘 | Onimaru R Fujino M Yamazaki K et aI | 2008 | Int J Radiat Oncol Biol Phys2008，70，2： | 1 |
| 7 | Spl decoy transletted to carcinoma cells suppresses the expression of vascular endothelial growth factor, transforming growth factor beta 1, and tissue factor and also cell growth and invasion activities显示文摘 | lshibashi H Nakagawa K Onimaru M | 2000 | Cancer Res2000，60，22： | 1 |
| 8 | Sp1 decoy transfected to carcinoma cells suppresses the expression of vascular endothelial growth factor,transforming growth factor betal,and tissue factor and also cell growth and invasion activities显示文摘 | Ishibashi H Nakagawa K Onimaru M | 2000 | Cancer Res2000，60，22： | 1 |
| 9 | Sp1 decoy transfected to carcinoma cells suppresses the expression of vascular endothelial growth factor,transforming growth factor beta1,and tissue factor,and also cell growth and invasion activities显示文摘 | Ishibashi H Nakagawa K Onimaru M | 2000 | Cancer Res2000，60，22： | 1 |
| 10 | Sp1 decoy transfected to carcinoma cells suppresses the expression of vascular endothelial growth factor,transforming growth factor beta1,and tissue factor,and also cell growth and invasion activities显示文摘 | Ishibashi H Nakagawa K Onimaru M | 2000 | Cancer Res2000，60，22： | 1 |
| 11 | Interplay between thermoelectric and structural properties of type-I clathrate K8Gag Sn38 single crystals 显示文摘 | Tanaka T Onimaru T Suekuni K | 2010 | Phys Rev B2010，81，16： | 1 |
| 12 | Prospective study on the effect of high resolution semiconductor PET in flu- oromi-sonidazole (FMISO)-guided intensity modulated ra- diation therapy (IMRT) dose-escalation simulation plan- ning in patients with nasopharyngeal carcinoma (NPC) 显示文摘 | Yasuda K Okamoto S Onimaru R | 2011 | Int J Radiat Oncol2011，81，5： | 1 |
| 13 | Sp1 decoy transfected to carcinoma cellssuppresses the expression of vascular endothelial growth factor,transforming growth factor beta1,and tissue factor and also cell growth and invasion activities显示文摘 | Ishibashi H Nakagawa K Onimaru M | 2000 | Cancer Res2000，60，22： | 1 |
| 14 | Mechanisms of heart development in the Japanese lamprey, Lethenteron japonicum 显示文摘 | Kokubo N Matsuura M Onimaru K | 2010 | Evol Dev2010，12，： | 1 |
| 15 | Steep dose-response relationship for stage I non-small-cell lung cancer using hypofractionated high-dose irradiation by real-time tumor-tracking radiotherapy显示文摘 | Onimaru R Fujino M Yamazaki K | 2008 | Int J Radiat Oncol Biol Phys2008，70，2： | 1 |
| 16 | Tolerance of organs at risk in smallvolume,hypofractionated,image-guided radiotherapy for primary and metastatic lung cancers显示文摘 | Onimaru R Shirato H Shimizu S Kitamura K Xu B Fukumoto S Chang TC Fujita K Oita M Miyasaka K Nishimura M Dosaka-Akita H | 2003 | Int J Radiat Oncol Biol Phys2003，56，1： | 1 |
| 17 | Spl decoy transfected to carcinoma cells suppresses the expression of vascular endothelial growth factor, transforming growth factor betal, and tissue factor and also cell growth and invasion activities显示文摘 | Ishibashi H Nakagawa K Onimaru M | 2000 | Cancer Res2000，60，22： | 1 |
| 18 | Excitation of inspiratory neurons by preinspiratory neurons in rat medulla in vitro 显示文摘 | Onimaru H Homma I Iwatsuki K | 1992 | Brain Res Bull1992，29，6： | 1 |
| 19 | Autocrine and/or paracrine growth of aggressive ATLL cells caused by HGF and c-Met显示文摘 | ONIMARU Y TSUKASAKI K MURATA K | 2008 | Int J Oncol2008，33，4： | 1 |
| 20 | Inhibitory effects of edaravone on the production of tumor necrosis factor-alpha in the isolated heart undergoing ischemia and reperfusion显示文摘 | Onimaru S Nakamura K Kariyazono H Ikeda R Ueno T Fukumoto Y | 2006 | Heart Vessels2006，21，： | 1 |
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