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| 1 | Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a^(-/-) mice显示文摘AIM: To investigate the ability of a Prunella vulgaris(P. vulgaris) ethanolic extract to attenuate spontaneous typhlocolitis in mdr1a-/- mice. METHODS: Vehicle(5% ethanol) or P. vulgaris ethanolic extract(2.4 mg/d) were administered daily by oral gavage to mdr1a-/- or wild type FVBWT mice from 6 wk of age up to 20 wk of age. Clinical signs of disease were noted by monitoring weight loss. Mice experiencingweight loss in excess of 15% were removed from the study. At the time mice were removed from the study, blood and colon tissue were collected for analyses that included histological evaluation of lesions, inflammatory cytokine levels, and myeloperoxidase activity. RESULTS: Administration of P. vulgaris extracts to mdr1a-/- mice delayed onset of colitis and reduced severity of mucosal inflammation when compared to vehicle-treated mdr1a-/- mice. Oral administration of the P. vulgaris extract resulted in reduced(P < 0.05) serum levels of IL-10(4.6 ± 2 vs 19.4 ± 4), CXCL9(1319.0 ± 277 vs 3901.0 ± 858), and TNFα(9.9 ± 3 vs 14.8 ± 1) as well as reduced gene expression by more than two-fold for Ccl2, Ccl20, Cxcl1, Cxcl9, IL-1 α, Mmp10, VCAM-1, ICAM, IL-2, and TNFα in the colonic mucosa of mdr1a-/- mice compared to vehicle-treated mdr1a-/-mice. Histologically, several microscopic parameters were reduced(P < 0.05) in P. vulgaris-treated mdr1a-/-mice, as was myeloperoxidase activity in the colon(2.49 ± 0.16 vs 3.36 ± 0.06, P < 0.05). The numbers of CD4+ T cells(2031.9 ± 412.1 vs 5054.5 ± 809.5) and germinal center B cells(2749.6 ± 473.7 vs 4934.0 ± 645.9) observed in the cecal tonsils of P. vulgaris-treated mdr1a-/- were significantly reduced(P < 0.05) from vehicle-treated mdr1a-/- mice. Vehicle-treated mdr1a-/- mice were found to produce serum antibodies to antigens derived from members of the intestinal microbiota, indicative of severe colitis and a loss of adaptive tolerance to the members of the microbiota. These serum antibodies were greatly reduced or absent in P. vulgaris-treated mdr1a-/- mice. CONCLUSION: The anti-inflammatory activity of P. vulgaris ethanolic extract effectively attenuated the severity of intestinal inflammation in mdr1a-/- mice. | Kelley MK Haarberg Meghan J Wymore Brand Anne-Marie C Overstreet Catherine C Hauck Patricia A Murphy Jesse M Hostetter Amanda E Ramer-Tait Michael J Wannemuehler | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 8 |
| 2 | Rickettsia and mollicute infections in hapatopancreatic cells of cultured Pacific white shrimp (Penaeus vannamei)显示文摘 | Krol R M Hawkins W E Overstreet R M | 1991 | J Invertebr Pathol1991，59，： | 1 |
| 3 | Reconstructing a binary tree from its traversals in doubly logarithmic CREW time显示文摘 | Olariu S Overstreet M Wen Z F | 1995 | Journal of Parallel and Distributed Computing1995，27，1： | 1 |
| 4 | Rickettsial and mollicute infectious in hepatopancreatic cells of cultured Pacific white shrimp (Penaeus vannamei)显示文摘 | Kroll R M Hawkins W E Overstreet R M | 1991 | J Invertebr Pathol1991，57，： | 1 |
| 5 | Interactive Distance Learning and Training over Intranets显示文摘 | H Abdel-Wahab C M Overstreet | 1997 | IEEE Internet Computing1997，1，1： | 1 |
| 6 | Annual changes in germinal epithelium determine male reproductive classes of the cobia显示文摘 | Brown N J Grier H J Overstreet R M | 2002 | J Fish Biol2002，，60： | 1 |
| 7 | Annual changes in germinal epithelium determine male reproductive classes of the cobia显示文摘 | Brown-Peterson N J Grier H J Overstreet R M | 2002 | Fish Biol2002，，60： | 1 |
| 8 | 5-HT(1A) receptor subsensitivity in infancy and supersensitivity in adulthood in an animal model of depression显示文摘 | Shayit M Yadid G Overstreet D H | 2003 | Brain Res2003，980，1： | 1 |
| 9 | Seasonal variation of ectosymbiotic ciliates on farmed and wild shrimps from coastal Yucatan,Mexico显示文摘 | L(O)PEZ-T(E)LLEZ N A VIDAL-MART(I)NEZ V M OVERSTREET R M | 2009 | Aquaculture2009，287，34： | 1 |
| 10 | Plant derivatives in the treatment of alcohol dependency 显示文摘 | Rezvani AH Overstreet DH Perfumi M | 2003 | Pharmacol Biochem Behav2003，75，3： | 1 |
| 11 | Text enhancement and content familiarity: the focus of learner attention 显示文摘 | Overstreet M | 1998 | Spanish Applied Linguistics1998，，2： | 1 |
| 12 | Dose-related carcinogenic effects of water-borne benzo(a)pyrene on livers of two small fish species显示文摘 | Hawkins W E Walker W W Overstreet R M | 1988 | Ecotoxicol Environ Saf1988，16，： | 1 |
| 13 | How do I care for a patient after PCI显示文摘 | Overstreet M | 2004 | Nursing2004，34，2： | 1 |
| 14 | The effect ofinduced anxiety on cognition: threat of shock enhances aversiveprocessing in healthy individuals 显示文摘 | Robinson O J Letkiewicz A M Overstreet C | 2011 | Cognitive Affective &Behavioral Neuroscience2011，11，2： | 1 |
| 15 | Sequential development and morphology of experimentally induced hepatic melano-macrophage centers in Rivulus marmoratus显示文摘 | VOGELBEIN W K FOURNIE J W OVERSTREET R M | 1987 | Journal of Fish Biology1987，，： | 1 |
| 16 | Rickeetsial and mollieute in fections in hepatopancreatie cells of cultured Pacific white shrimp (Penaeus vannamei) 显示文摘 | Krol R M Hawkins W E Overstreet R M | 1991 | Invetebr Pathol1991，57，： | 1 |
| 17 | How do I care for a patient after PCI?显示文摘 | Overstreet M | 2004 | Nursing2004，34，2： | 1 |
| 18 | Sequential development and morphology of experimentally induced hepatic melano-macrophage centers inRivulus marmoratus显示文摘 | VOGELBEIN W K FOURNIE J W OVERSTREET R M | 1987 | Journal of Fish Biology1987，，： | 1 |
| 19 | Formulaie disclaimers 显示文摘 | Overstreet M and Yule G | 2001 | Journal of Pragmafies2001，，33： | 1 |
| 20 | Reconstructing abinary tree from its traversals in doubly logarithmic CREWtime 显示文摘 | Olariu S Overstreet M Wen Zhaofang | 1995 | Journal of Parallel and Distributed Computing1995，27，1： | 1 |
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