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| 1 | Characterization of focal liver lesions with SonoVue~-enhanced sonography: International multicenter-study in comparison to CT and MRI显示文摘AIM: To evaluate in a multicenter study whether the sonographic characterization of focal liver lesions can be improved using SonoVueüà-enhancement; and to compare this method with computed tomography (CT) and magnetic resonance imaging (MRI). METHODS: One hundred and thirty four patients with one focal liver lesion detected in baseline ultrasound (US) were examined with conventional US, contrastenhanced US (n = 134), contrast-enhanced CT (n = 115) and/or dynamic contrast-enhanced MRI (n = 70). The lesions were classified as malignant, benign or indeterminate and the type of lesion was determined. The f inal diagnosis based on the combined information of all imaging examinations, clinical information and histology (n = 32) was used. Comparisons were made to see whether the addition of contrast-enhanced US led to the improvement of the characterization of doubtful focal liver lesions. RESULTS: In comparison with unenhanced US, SonoVue markedly improves sensitivity and specificity for the characterization (malignant/benign) of focal liver lesions. In comparison with CT and/or dynamic MRI, SonoVueüà -enhanced sonography applied for characterization of focal liver lesions was 30.2% more sensitive in the recognition of malignancy and 16.1% more specific in the exclusion of malignancy and overall 22.9% more accurate. In the subgroup with confirmative histology available (n = 30), sensitivity was 95.5% (CEUS), 72.2% (CT) and 81.8% (MRI), and specif icity was 75.0% (CEUS), 37.5% (CT) and 42.9% (MRI). The sensitivity and specif icity of CEUS for the identif ication of focal nodular hyperplasia (FNH) and hemangiomas was 100% and 87%, resulting in an accuracy of 94.5%. CONCLUSION: SonoVueüà-enhanced sonography emerges as the most sensitive, most specif ic and thus most accurate imaging modality for the characterization of focal liver lesions. | Hervé Trillaud Jean-Michel Bruel Pierre-Jean Valette Valérie Vilgrain Gérard Schmutz Raymond Oyen Wieslaw Jakubowski Jan Danes Vlastimil Valek Christian Greis | 2009 | World Journal of Gastroenterology2009，15，30： | 34 |
| 2 | Rat model of cholelithiasis with human gallstones implanted in cholestasis-induced virtual gallbladder显示文摘AIM:To facilitate translational research on cholelithiasis,we have developed a rat model of human gallstones by exploiting the unique biliopancreatic features of this species.METHODS:Under anesthesia,16 adult rats of equal genders underwent two times of abdominal surgery.First,their common bile duct(CBD)was ligated to cause cholestasis by total biliary obstruction(TBO).On day 0,1,3,7,14,21 and 28 after TBO,magnetic resonance imaging(MRI)was conducted to monitor the dilatation of the CBD,and blood was sampled to analyze total serum bilirubin(TSB).Secondly,on day 30,the abdomen was re-opened and gallstone(s)collected from human patients were implanted in the dilated CBD asa virtual gallbladder(VGB),which was closed by suture ligation.This rat cholelithiasis model was examined by MRI,clinical observation,microcholangiography and histology.RESULTS:All rats survived two laparotomies.After ligation,the CBD was dilated to a stable size of 4 to30 mm in diameter on day 21-28,which became a VGB.The rats initially showed signs of jaundice that diminished over time,which paralleled with the evolving TSB levels from 0.6±0.3 mg/d L before ligation,through a peak of 10.9±1.9 mg/dL on day 14,until a nearly normalized value after day 28.The dilated CBD with thickened wall allowed an incision for implantation of human gallstones of 1-10 mm in diameter.The rat cholelithiasis was proven by in vivo MRI and postmortem microcholangiography and histomorphology.CONCLUSION:A rat model cholelithiasis with human gallstones has been established,which proves feasible,safe,reliable,nontoxic and cost-effective.Given the gallstones of human origin,applications of this model may be of help in translational research such as optical detection and lysis of gallstones by systemic drug administration. | Marlein Miranda Cona Yewei Liu Ting Yin Yuanbo Feng Feng Chen Stefaan Mulier Yue Li Jian Zhang Raymond Oyen Yicheng Ni | 2016 | World Journal of Methodology2016，6，2： | 7 |
| 3 | Peritoneal Carcinomatosis of Colorectal Origin: Incidence and Current Treatment Strategies显示文摘 | Manuel J. Koppe Otto C. Boerman Wim J. G. Oyen Robert P. Bleichrodt | 2006 | Annals of Surgery2006，，2： | 3 |
| 4 | Plasma Tranexamic Acid Concentrations During Cardiopulmonary Bypass显示文摘 | Bridget K. Fiechtner Gregory A. Nuttall Michael E. Johnson Yue Dong Nuntiya Sujirattanawimol William C. Oliver Rajbir S. Sarpal Lance J. Oyen Mark H. Ereth | 2001 | Anesthesia and Analgesia2001，，5： | 2 |
| 5 | Peritoneal Carcinomatosis of Colorectal Origin: Incidence and Current Treatment Strategies显示文摘 | Manuel J. Koppe Otto C. Boerman Wim J. G. Oyen Robert P. Bleichrodt | 2006 | Annals of Surgery2006，，2： | 2 |
| 6 | Hierarchical crosstraining in work-in-process-constrained systems 显示文摘 | Gel E S Hopp W J Van Oyen M P | 2007 | lie Transactions2007，39，2： | 1 |
| 7 | Development of broodstock diets for the European sea bass (Dicentrarchus labrax)with special emphasis on the importance of n-3 and n-6 HUFA to reproductive performance 显示文摘 | Bruce M P Oyen F Bell J G | 1999 | Aquaculture1999，177，： | 1 |
| 8 | Gender differ- ences in healthy life years within the EU:an exploration of the 'health - survival' paradox 显示文摘 | Van Oyen H Nusselder W Jagger C | 2013 | Int J Public Health2013，58，1： | 1 |
| 9 | Sterically stabilized liposomes labeled with indium Ⅲ to image focal infection 显示文摘 | Boerman O C Storm G Oyen W J | 1995 | J Nucl Med1995，36，9： | 1 |
| 10 | Diffusion weighted MR imaging of kidneys in healthy volunteers and patients with parenchymal diseases : initial experience 显示文摘 | Thoeny HC Keyzer FD Oyen RH | 2005 | Radiology2005，235，3： | 1 |
| 11 | Benign hyperplastic nodules that originate in the peripheral zone of the prostate gland显示文摘 | Oyen RH Van de voorde QM Van Poppel HP | 1993 | Radiology1993，189，： | 1 |
| 12 | Identification of residual metabolic active areas within NSCLC tumours using a pre-radio- therapy FDG-PET-CT scan: a prospective validation显示文摘 | Aerts HJ Bussink J Oyen WJ | 2012 | Lung Cancer2012，75，1： | 1 |
| 13 | Necrotizing Pancreatitis:Pathophysiology,Diagnosis,and Acute Care Management显示文摘 | Wrobleski DM Barth MM Oyen LJ | 1999 | AACN Aduanced Critical Care1999，10，4： | 1 |
| 14 | From anatomical to biological target volumes:the role of PET in radiation treatment planning显示文摘 | Schinagl DA Kaanders JH Oyen WJ | | 0，，： | 1 |
| 15 | Analytical techniques for indentation of viscoelastic materials显示文摘 | Oyen M.L | | 0，，： | 1 |
| 16 | High prevalence of vitamin d deficiency in pregnant women : a national cross - sectional survey 显示文摘 | Vandevijvere S Amsalkhir S Van Oyen H | 2012 | PLoS One2012，7，43： | 1 |
| 17 | Diffussion-weighted MR imaging of kidneys in healthy volunteers and patients with parenchmal diseases: initial experience显示文摘 | Thoeny HC De Keyzer F Oyen RH | 2005 | Radiology2005，235，： | 1 |
| 18 | Spherical indentation load-relaxation of soft biological tissues显示文摘 | Mattice J M Lau A G Oyen M L | | 0，，： | 1 |
| 19 | The 1991-2004 Evolution in Life Expectancy by Educational Level in Belgium Based on Linked Census and Population Register Data显示文摘 | Deboosere Patrick Gadeyne Sylvie Van Oyen Herman | 2009 | European Journal of Population2009，，2： | 1 |
| 20 | Diffusion weighted MR imaging of kidneys in healthy volunteers and patients with parenchymal diseases : initial experience 显示文摘 | Thoeny HC De Keyzer F Oyen RH | 2005 | Radiology2005，235，3： | 1 |
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